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  4. Recombinant Mouse Solute carrier family 15 member 4 (Slc15a4), partial

Recombinant Mouse Solute carrier family 15 member 4 (Slc15a4), partial

  • 中文名称：
    小鼠Slc15a4重组蛋白
  • 货号：
    CSB-YP849656MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc15a4重组蛋白
  • 货号：
    CSB-EP849656MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc15a4重组蛋白
  • 货号：
    CSB-EP849656MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc15a4重组蛋白
  • 货号：
    CSB-BP849656MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc15a4重组蛋白
  • 货号：
    CSB-MP849656MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc15a4
  • Uniprot No.：
  • 别名：
    Slc15a4; Solute carrier family 15 member 4; Peptide transporter 4; Peptide/histidine transporter 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response. Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans. Transporter activity is pH-dependent and maximized in the acidic lysosomal environment. Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand. Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5. Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation. Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses.
  • 基因功能参考文献：
    1. SLC15A4-mediated optimization of the endolysosomal state is integral to a Toll-like receptor 7-triggered, mTOR-dependent interferon regulatory factor 7-type I interferon circuit that leads to autoantibody production. PMID: 25238095
    2. We found marked changes in protein expression and functional activity of PhT1 and PepT2, the former predominating in adult and the latter in neonate PMID: 24548120
    3. the feeble mutation (Slc15a4) affecting Plasmacytoid dendritic cells is dispensable for immunity during an acute infection; however, data show that feeble mice failed to control a chronic infection PMID: 23028315
    4. results demonstrate pDCs and the production of type I IFNs by these cells are critical contributors to the pathogenesis of lupus-like autoimmunity in these models. IRF8 and SLC15A4 may provide important targets for therapeutic intervention in human lupus PMID: 23382217
    5. SLC15A4 promotes colitis through Toll-like receptor 9 and NOD1-dependent innate immune responses. PMID: 21277849
    6. The identification of the feeble mutation led to our subsequent observations that AP-3, as well as the BLOC-1 and BLOC-2 are essential for plasmacytoid dendritic cells signaling through TLR7 and TLR9. PMID: 21045126

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  • 亚细胞定位：
    Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    PTR2/POT transporter (TC 2.A.17) family
  • 组织特异性：
    Preferentially expressed in immune tissues, including B-cells and dendritic cells. Highly expressed in macrophages.
  • 数据库链接：

    KEGG: mmu:100561

    STRING: 10090.ENSMUSP00000031367

    UniGene: Mm.28506