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  4. Recombinant Mouse Small ubiquitin-related modifier 2 (Sumo2)

Recombinant Mouse Small ubiquitin-related modifier 2 (Sumo2)

  • 中文名称：
    小鼠Sumo2重组蛋白
  • 货号：
    CSB-YP022949MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sumo2重组蛋白
  • 货号：
    CSB-EP022949MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sumo2重组蛋白
  • 货号：
    CSB-EP022949MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sumo2重组蛋白
  • 货号：
    CSB-BP022949MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sumo2重组蛋白
  • 货号：
    CSB-MP022949MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sumo2
  • Uniprot No.：
  • 别名：
    Sumo2; Smt3b; Smt3h2; Small ubiquitin-related modifier 2; SUMO-2; SMT3 homolog 2; Ubiquitin-like protein SMT3B; Smt3B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-93
  • 氨基酸序列
    MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRF RFDGQPINETDTPAQLEMEDEDTIDVFQQQTGG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX.
  • 基因功能参考文献：
    1. SUMO2-mediated activation of calcineurin-NFAT signaling in cardiomyocytes translated into a hypertrophic phenotype. Increased SUMO2-mediated sumoylation in models of cardiomyopathy were observed. PMID: 27767176
    2. integrity is required for PLK1 localization with SUMO-1 but not with SUMO-2/3. Inhibition of SUMOylation disrupts proper meiotic bipolar spindle organization and spindle-kinetochore attachment. PMID: 29269218
    3. SUMO-2 inhibits aggregation of CPEB3. PMID: 26074071
    4. The present study used immunohistochemical and immunoblot analysis with the different developmental stages of mice and demonstrated the developmentally regulated distribution of SUMO2/3 in the brain. PMID: 24639124
    5. SUMO-2-Tg mouse lines exhibited cardiomyopathy with various severities. SUMO-2 directly regulated apoptosis by at least partially targeting calpain 2 and calpastatin. PMID: 25857621
    6. Results indicate that a functional SUMO1-3 expression is essential for emotionality and cognition PMID: 24690371
    7. Expression levels and not functional differences between SUMO2 and SUMO3 are critical for normal embryogenesis. PMID: 24891386
    8. Stress-induced phosphorylation of Thr486 in c-Myb by p38 mitogen-activated protein kinases attenuates conjugation of SUMO-2/3. PMID: 24257756
    9. post-ischemic activation of SUMO2/3 conjugation may define the fate of neurons exposed to a transient interruption of blood supply PMID: 22945749
    10. Alterations in SUMO substrate conjugation may occur and global posttranslational modifications by ubiquitin may play an important role in the mechanisms underlying Alzheimer disease. PMID: 21843595
    11. activation of SUMO2/3 conjugation is an endogenous neuroprotective stress response. PMID: 21863037
    12. These results indicate that the functional role of SUMO-2/3 in the regulation of NFkappaB activity was conserved during evolution. PMID: 21632113
    13. disruption of the retinoic acid receptor alpha gene in the testis resulted in alteration of SUMO-2/3 subcellular localization PMID: 20075418
    14. results are consistent with the important roles of SUMO1, SUMO2 and SUMO3 isoforms in stress responses in germ cells PMID: 20385780
    15. p53 and pRB can be sumoylated by SUMO-2/3 in vivo, and such modification of p53 and pRB may play roles in premature senescence and stress response PMID: 17012228
    16. SUMO-2/3 proteins conjugate to c-Myb transcription factor and negatively regulate its activity in cells under stress. PMID: 17077080
    17. BLM, the RecQ DNA helicase mutated in Bloom syndrome, is preferentially modified by SUMO-2/3 both in vitro and in vivo PMID: 18708356
    18. The ability of SUMO isoforms to substitute for one another has important implications for rational targeting of the SUMO pathway. PMID: 19033381

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  • 亚细胞定位：
    Nucleus. Nucleus, PML body.
  • 蛋白家族：
    Ubiquitin family, SUMO subfamily
  • 数据库链接：

    KEGG: mmu:170930

    STRING: 10090.ENSMUSP00000115044

    UniGene: Mm.29923