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  4. Recombinant Mouse Serum paraoxonase/arylesterase 1 (Pon1)

Recombinant Mouse Serum paraoxonase/arylesterase 1 (Pon1)

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  • 中文名称：
    小鼠Pon1重组蛋白
  • 货号：
    CSB-EP347323MO
  • 规格：
    ￥2340
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Pon1
  • Uniprot No.：
  • 别名：
    Pon1; Pon; Serum paraoxonase/arylesterase 1; PON 1; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1; Aromatic esterase 1; A-esterase 1; Serum aryldialkylphosphatase 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    39.4 kDa
  • 表达区域：
    2-355aa
  • 氨基酸序列
    AKLLALTLVGLVLALYKNHRSSYQTRLNAFREVTPVELPNCNLVKGIETGAEDLEILPNGLTFFSTGLKYPGIKSFDPSKPGKILLMDLNKKEPAVSELEIIGNTLDISSFNPHGISTFTDEDNTVYLLVVNHPDSSSTVEVFKFQEEERSLLHLKTITHELLPSINDIAAIGPESFYATNDHYFADPYLRSWEMYLGLSWSNVVYYSPDKVQVVAEGFDFANGIGISLDGKYVYIAELLAHKIHVYEKHANWTLTPLKVLNFDTLVDNISVDPVTGDLWVGCHPNGMRIFFYDAENPPGSEVLRIQNILSEDPKITVVYAENGTVLQGTTVASVYKGKLLIGTVFHKALYCDL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    Tag-Free
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification.
  • 基因功能参考文献：
    1. Study shows that PON1 can significantly relieve airway inflammation and airway remolding in asthma mice, and inhibit the secretion of LPS induced macrophage inflammatory cytokines and the proliferation of lung fibroblasts. These results suggest that PON1 may be involved in airway inflammation and remodeling in asthma. PMID: 28657647
    2. PON1 overexpression protects against AAA progression by reducing oxidative stress, apoptosis and inflammation PMID: 26993251
    3. Paraoxonase 1 (PON1) influence circadian gene expression and period length PMID: 27010443
    4. results suggest that Hyperhomocysteinemia plays an intricate role in dysfunctional HDL, owing to the lack of PON1. This contributes to vascular endothelial impairment and atherosclerosis. PMID: 26176406
    5. Maternal PON1 status modulates the effects of repeated gestational chlorpyrifos oxon exposure on fetal-brain gene expression and on inhibition of both maternal and fetal biomarker enzymes. PMID: 25070982
    6. 5,6-dihydroxyeicosatrienoate-1,5-lactone, a stable metabolite of arachidonic acid, is a potential substrate for PON1. PMID: 25958017
    7. HDL (mostly HDL3), stimulates PON1 antiatherogenic activities in mouse macrophages. PMID: 25230879
    8. Findings suggest that Pon1 interacts with diverse cellular processes from energy metabolism and anti-oxidative defenses to cell cycle, cytoskeleton dynamics, and synaptic plasticity essential for normal brain homeostasis PMID: 24844689
    9. The study demonstrated a significant decline in PON1 activity which correlates with increased LDL oxidation after 8 months of age in Wistar rats. PMID: 24971380
    10. PON1 plays a protective role against hepatic derangements, secondary to fat and cholesterol overnutrition. PON1 deficiency is associated with oxidative stress and metabolic alterations leading to liver steatosis. PMID: 23448543
    11. PON1 is not essential for normal development, function, ageing, and the defense against light damage of the mouse retina. PMID: 25028362
    12. Suggest that PON1 decreases sustained pro-inflammatory reactions, which subsequently can attenuate plaque progression. PMID: 23582715
    13. PON1 plays a beneficial role in glucose regulation and metabolism and may serve as an important tool in diabetes control. PMID: 23639858
    14. PON1 activity was found to be increased in diabetic mice after administration of aqueous Murraya koenigii leaves extract. PMID: 23207871
    15. Pon1 protects mice against Hcy-thiolactone neurotoxicity by hydrolyzing it in the brain. PMID: 22406444
    16. PON1 is a potent anti-diabetic enzyme that exerts this protection against diabetes through its antioxidative, as well as via its insulin stimulation properties on beta-cells. PMID: 21862013
    17. antiatherosclerotic properties of HDL can be attributed to two major mechanisms of action of PON1: protecting macrophages from TG-induced oxidative modification and (ii) reduction of peroxide levels in oxidized TGs. PMID: 21530644
    18. PON1 status plays a critical role in modulating the effects of neonatal chlor- pyrifos oxon exposure in the developing brain. PMID: 21673326
    19. PON1 status modulates the ability of CaE to detoxicate OP compounds from specific mixed insecticide exposures [review] PMID: 20221870
    20. analysis of PON1 and oxidative stress in human sepsis and an animal model of sepsis [review] PMID: 20221873
    21. paraoxonase 1 has a role in the detoxification of homocysteine thiolactone [review] PMID: 20221875
    22. PON1 is affectd by HDL mimetic peptide 4F [review] PMID: 20221879
    23. Mouse serum paraoxonase-1 lactonase activity is specific for medium-chain length fatty acid lactones. PMID: 21044894
    24. PON1 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli. PMID: 20931267
    25. PON1 deficiency in mice is associated with decreased macrophage SR-BI expression, decreased cellular HDL binding, and consequently the loss of HDL-mediated cytoprotection against apoptosis PMID: 20149374
    26. PON1 regulates adrenal corticosterone biosynthesis at two levels: (a) via an accessory role in HDL binding properties, and (b) a supportive role in SR-BI expression and cholesteryl ester supply to the cells. PMID: 20189567
    27. Paraoxonase 1 protects high-density lipoprotein integrity and function in Paraoxonase 1 transgenic mice PMID: 11798161
    28. antioxidant PON-1 is regulated at the mRNA level in a gender-specific manner by proinflammatory LPS and anti-inflammatory dexamethasone PMID: 12654470
    29. mouse PON1 is quantitatively associated with high density lipoproteins PMID: 14703510
    30. liver paraoxonase-1 gene expression is downregulated in hyperhomocysteinemia PMID: 15213869
    31. Incubation of isolated human apoA-II with control mouse plasma at 37 degrees C decreased PON1 activity and displaced the enzyme from HDL. PMID: 15388641
    32. PON1 may contribute to the attenuation of atherosclerosis development by its ability to act on macrophage phospholipids PMID: 15721011
    33. genotypes and risk of insecticide toxicity PMID: 15977192
    34. paraoxonase interruption of bacterial communication represents a novel mechanism to modulate quorum-sensing by bacteria PMID: 16260097
    35. Hepatic PON1 and CYP7A1 mRNA expression is repressed by bile acids via FXR-mediated induction of FGF15 PMID: 16284190
    36. the catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux PMID: 16407304
    37. SR-BI deficiency results in a reduced activity of the antioxidant enzyme PON1 and a significant increase in oxidative stress, potentially contributing to the proatherogenic effect of SR-BI deficiency. PMID: 17717299
    38. Our data revealed significant vascular changes in adhesion, oxidative stress, and thrombotic tendencies in Pon1(-/-) mice in the absence of hyperlipidemia and systemic inflammation. PMID: 18402813
    39. Serum albumin is as efficient as paraxonase in the detoxication of paraoxon at toxicologically relevant concentrations. PMID: 18597495
    40. Pon1 does not show a parent-of-origin preference in its allelic expression, but has dramatic variations in allele-specific expression occurring throughout development PMID: 18678600
    41. N-acetylcysteine may be effective in the treatment of colitis through its up-regulating PON1 and scavenging oxygen-derived free radicals. PMID: 19034653
    42. The anti-atherogenic biological activities were studied in vitro using serum or cell cultures, and also in vivo, using PON 1/2/3 knockout or transgenic mice, as well as humans - healthy volunteers and atherosclerotic patients. PMID: 19082953
    43. Knockout and transgenic PON1 mice were used to study the toxicity of organosphosphorus pesticides. PMID: 19371602
    44. Studies have demonstrated the antioxidative and atheroprotective effects of PON1. PMID: 19474728
    45. Reduced PON1 activity may be involved in the pathogenesis of asthma. PMID: 19556304

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  • 亚细胞定位：
    Secreted, extracellular space.
  • 蛋白家族：
    Paraoxonase family
  • 组织特异性：
    Plasma, liver, kidney, heart, brain, small intestine and lung. In the plasma, associated with HDL.
  • 数据库链接：

    KEGG: mmu:18979

    STRING: 10090.ENSMUSP00000002663

    UniGene: Mm.237657