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  4. Recombinant Mouse Serine/threonine-protein phosphatase 6 catalytic subunit (Ppp6c)

Recombinant Mouse Serine/threonine-protein phosphatase 6 catalytic subunit (Ppp6c)

  • 中文名称：
    小鼠Ppp6c重组蛋白
  • 货号：
    CSB-YP863425MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ppp6c重组蛋白
  • 货号：
    CSB-EP863425MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ppp6c重组蛋白
  • 货号：
    CSB-EP863425MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ppp6c重组蛋白
  • 货号：
    CSB-BP863425MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ppp6c重组蛋白
  • 货号：
    CSB-MP863425MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ppp6c; Serine/threonine-protein phosphatase 6 catalytic subunit; PP6C; EC 3.1.3.16
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-305
  • 氨基酸序列
    MAPLDLDKYV EIARQCKYLP ENDLKRLCDY VCDLLLEESN VQPVSTPVTV CGDIHGQFYD LCELFRTGGQ VPDTNYIFMG DFVDRGYYSL ETFTYLLALK AKWPDRITLL RGNHESRQIT QVYGFYDECQ TKYGNANAWR YCTKVFDMLT VAALIDEQIL CVHGGLSPDI KTLDQIRTIE RNQEIPHKGA FCDLVWSDPE DVDTWAISPR GAGWLFGAKV TNEFVHINNL KLICRAHQLV HEGYKFMFDE KLVTVWSAPN YCYRCGNIAS IMVFKDVNTR EPKLFRAVPD SERVIPPRTT TPYFL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation.
  • 基因功能参考文献：
    1. Ppp6c deficiency enhances K-ras(G12D) -dependent tumor promotion PMID: 29758119
    2. the Ppp6c phosphatase domain is indispensable for mouse embryogenesis after implantation. PMID: 26868000
    3. findings uncover a hitherto unknown role for PP6 as an indispensable regulator of oocyte meiosis and female fertility. PMID: 26349807
    4. Data identify NF-kappaB-induced miR-31 and its target, ppp6c, as critical factors for the hyperproliferation of epidermis in psoriasis. PMID: 26138368
    5. Ppp6c deficiency predisposes mice to skin carcinogenesis initiated by DMBA. PMID: 25486434
    6. Ppp6c deficiency underlies molecular events that drive outgrowth of initiated keratinocytes harboring UVB-induced mutated p53 PMID: 26054846
    7. Our studies demonstrate that PP6 acts as a critical negative regulator of naive T cell homeostasis PMID: 25609840
    8. PP6 regulates the sensitivity of GBM cells to radiation, and suggest small molecules disrupting or inhibiting PP6 association with DNA-PK is a potential radiosensitizer for GBM. PMID: 22158480
    9. alpha4 expression differentially increased or decreased phosphorylation of endogenous phosphoproteins, consistent with opposing effects on PP2A and PP6 [PP6] PMID: 16895907

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  • 亚细胞定位：
    Mitochondrion. Cytoplasm.
  • 蛋白家族：
    PPP phosphatase family, PP-6 (PP-V) subfamily
  • 组织特异性：
    Ubiquitously expressed in all tissues tested with strongest expression in lung, spleen, liver, kidney and brain. Weaker expression observed in bladder, pancreas, heart and skeletal muscle.
  • 数据库链接：

    KEGG: mmu:67857

    STRING: 10090.ENSMUSP00000028087

    UniGene: Mm.389242