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  4. Recombinant Mouse Serine/threonine-protein kinase RIO1 (Riok1)

Recombinant Mouse Serine/threonine-protein kinase RIO1 (Riok1)

  • 中文名称：
    小鼠Riok1重组蛋白
  • 货号：
    CSB-YP856374MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Riok1重组蛋白
  • 货号：
    CSB-EP856374MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Riok1重组蛋白
  • 货号：
    CSB-EP856374MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Riok1重组蛋白
  • 货号：
    CSB-BP856374MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Riok1重组蛋白
  • 货号：
    CSB-MP856374MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Riok1
  • Uniprot No.：
  • 别名：
    Riok1; Serine/threonine-protein kinase RIO1; EC 2.7.11.1; EC 3.6.3.-; RIO kinase 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-567
  • 氨基酸序列
    MDCSLDRMAS VVPGQFDDAD SSDSENKELQ PIHAEDGGVL LKSLQNAAAE VKGDAETDEE DDYDDDDDWY LDDATGKLTK GCTWNGGSNY QANRQTSNYN SAKMSTPIDK SLRKFENKIN LNKLNVTDSV TNKVTVKLRQ KEAESYRIKD KADRATVEQV LDPRTRMILF KLLHKDHISE IHGCISTGKE ANVYYASTPS GESRAIKIYK TSILMFKDRD KYVTGEFRFR RGYCKGNPRK MVRTWAEKEM RNLCRLKTAN IPCPEPIRLR SHVLLMGFIG KDDMPAPLLK NVQLSESKAR ELYLQVIQYM RKMYQDARLV HADLSEFNML YHGGDVYIID VSQSVEHDHP HALEFLRKDC TNVNDFFSKH AVAVMTVREL FDFVTDPSIT ADNMDAYLEK AMEIASQRTK EEKTSQDHVD EEVFKQAYIP RTLNEVKNYE RDVDIMMRLK EEDMALNTQQ DNILYQTVMG LKKDLSGVQK VPALLESEVK EETCFGSDDA GGSECSDTVS EEQEDQAGCR NHIADPDIDK KERKKMVKEA QREKRKNKIP KHVKKRKEKT AKAKKGK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. The catalytic activity regulates its dynamic association with the 40S subunit. In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation.
  • 基因功能参考文献：
    1. Describes a function for human RIOK1 as a component of the protein arginine methyltransferase 5 complex, conferring specificity for nucleolin as a methylation substrate. PMID: 21081503
  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Protein kinase superfamily, RIO-type Ser/Thr kinase family
  • 数据库链接：

    KEGG: mmu:71340

    STRING: 10090.ENSMUSP00000021866

    UniGene: Mm.297130