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  4. Recombinant Mouse Septin-4 (Sept4)

Recombinant Mouse Septin-4 (Sept4)

  • 中文名称：
    小鼠Sept4重组蛋白
  • 货号：
    CSB-YP021027MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sept4重组蛋白
  • 货号：
    CSB-EP021027MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sept4重组蛋白
  • 货号：
    CSB-EP021027MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sept4重组蛋白
  • 货号：
    CSB-BP021027MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sept4重组蛋白
  • 货号：
    CSB-MP021027MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Septin4; Pnutl2; Sept4; Septin-4; Brain protein H5; Peanut-like protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-478
  • 氨基酸序列
    MDHSLGWQGN SVPEDGTEAG IKHFLEDSSD DAELSKFVKD FPGSEPYHSA ESKTRVARPQ ILEPRPQSPD LCDDDVEFRG SLWPQPSDSQ QYFSAPAPLS PSSRPRSPWG KLDPYDSSED DKEYVGFATL PNQVHRKSVK KGFDFTLMVA GESGLGKSTL VNSLFLTDLY RDRKLLGAEE RIMQTVEITK HAVDIEEKGV RLRLTIVDTP GFGDAVNNTE CWKPVAEYID QQFEQYFRDE SGLNRKNIQD NRVHCCLYFI SPFGHGLRPL DVEFMKALHQ RVNIVPILAK ADTLTPPEVD RKKCKIREEI EHFGIKIYQF PDCDSDEDED FKLQDQALKE SIPFAVIGSN TVVEARGRRV RGRLYPWGIV EVENPGHCDF VKLRTMLVRT HMQDLKDVTR ETHYENYRAQ CIQSMTRLVV KERNRNKLTR ESGTDFPIPA VPPGTDPETE KLIREKDEEL RRMQEMLHKI QRQMKETH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Filament-forming cytoskeletal GTPase (Probable). Plays an important role in male fertility and sperm motility. During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm. Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development.
  • 基因功能参考文献：
    1. Adenovirus-Sept4 can attenuate the development of liver fibrosis induced by S. japonicum through apoptosis. PMID: 26190030
    2. The inhibition of the expression of the SEPT4 by praziquantel might be due to alleviation of the inflammatory response at the chronic and advanced stage of S. japonicum infection. PMID: 25582427
    3. The hypothetical pathogenicity by the chronic overload of SEPT4 alone, if any, is insufficient to trigger neurodegenerative process in the mouse brain. PMID: 23938054
    4. Sept4/ARTS(-/-) mice display marked improvement in wound healing and regeneration of hair follicles. PMID: 23788729
    5. Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. PMID: 23479728
    6. Sept4 and alpha-SMA may interact together in hepatic stellate cells (HSCs). Sept4 seems to be involved in the formation of inflammatory granulomata and subsequent liver fibrosis by regulating HSCs activation. PMID: 21679490
    7. ARTS (Septin 4) promotes apoptosis mainly through binding and antagonizing XIAP. PMID: 21695558
    8. Loss of Sept4 is associated with myofibroblastic transformation of hepatic stellate cells and results in liver fibrosis. PMID: 21763422
    9. Findings suggest that Sept4-null mice develop malignancies due to increased resistance of their HSPCs to apoptosis. PMID: 20952537
    10. These results suggest that Sept14 is involved in neuronal migration in cerebral cortex via interaction with Sept4. PMID: 20181826
    11. On Sept4(-/-) sperm, domain confinement was lost, and basigin localized over the entire plasma membrane. PMID: 20042538
    12. M-Septin is a novel mitochondrial septin that interacts with CRMP/CRAM in developing neurons. PMID: 12581152
    13. Cortical organization based on circular assembly of the septin cytoskeleton is essential for the structural and mechanical integrity of mammalian spermatozoa. PMID: 15737930
    14. Sept4 proteins play distinct but evolutionarily conserved functions in different cellular compartments. PMID: 15737931
    15. hepatic stellate cell-specific septin subunit Sept4 and perhaps the septin system are involved in the suppressive modulation of myofibroblastic transformation and fibrogenesis associated with liver diseases PMID: 18804890
    16. The interaction of DNAJB13 with SEPT4 in vitro and its spatiotemporal association with the annulus during sperm flagellum development suggest that DNAJB13 may be involved in assembling the annulus structure. PMID: 19298648

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  • 亚细胞定位：
    Cytoplasm. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle. Cell projection, axon. Cell projection, dendrite. Perikaryon.; [Isoform 1]: Cytoplasm.; [Isoform 4]: Mitochondrion. Cytoplasm, cytosol.
  • 蛋白家族：
    TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family
  • 组织特异性：
    [Isoform 1]: Highly expressed in the brain and testis and, to a lesser extent in the heart, lung and kidney. In the brain, abundant in areas of high cell density, particularly in the stria terminalis.; [Isoform 4]: Predominantly expressed in embryonic bra
  • 数据库链接：

    KEGG: mmu:18952

    STRING: 10090.ENSMUSP00000018544

    UniGene: Mm.2214