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  4. Recombinant Mouse Sclerostin domain-containing protein 1 (Sostdc1)

Recombinant Mouse Sclerostin domain-containing protein 1 (Sostdc1)

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  • 中文名称：
    小鼠Sostdc1重组蛋白
  • 货号：
    CSB-EP866588MO
  • 规格：
    ￥2328
  • 促销：
    促销单品低至599元起
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Sostdc1
  • Uniprot No.：
  • 别名：
    Sostdc1; Sostl; Usag1; Sclerostin domain-containing protein 1; Ectodermal BMP inhibitor; Ectodin; Sclerostin-like protein; Uterine sensitization-associated gene 1 protein; USAG-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    27.6 kDa
  • 表达区域：
    24-206aa
  • 氨基酸序列
    FKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHFSSTGLDRNSRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFESVSPAKPAQHHRERKRASKSSKHSLS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.
  • 基因功能参考文献：
    1. Sostdc1 may promote and maintain mesenchymal stem cell quiescence in the periosteum. PMID: 27102547
    2. suggest that RUNX2 and USAG-1 act in an antagonistic manner PMID: 27518316
    3. the in vivo inter-relationships between Bmp7 and Usag-1, was examined. PMID: 27178071
    4. Findings strongly suggest that Wise and Sost are key modulators of bone development through the ability of their encoded proteins to interact with Lrp5 and control the balance or levels of Wnt signaling. PMID: 24789067
    5. Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations PMID: 24816837
    6. Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner. PMID: 23994639
    7. Wise controls the number and distribution of the mammary epithelial cells via inhibition of Wnt/beta-catenin signaling. PMID: 23293290
    8. Data suggest that Sostdc1 primarily regulates bone morphogenetic protein pathway in pancreatic islets; knockout/mutation of Sostdc1 enhances down-regulation of Ctgf (connective tissue growth factor) and gremlin in islets after high-fat diet. PMID: 22829579
    9. The data demonstrate that simvastatin contributes to prevent the progression of renal fibrosis by upregulating BMP-7-mediated anti-fibrotic signaling and that one aspect of crucial efficacies is achieved by regulating HOXA13 and USAG-1. PMID: 22525429
    10. The data suggested that functions of Sostdc1 can be largely attributed to its ability to attenuate Wnt/beta-catenin signaling. PMID: 22509524
    11. analyses demonstrate that the Fgf and Shh pathways are major downstream targets of Wise-regulated Wnt signaling. PMID: 20724449
    12. the pathogenetic role of USAG-1 in Col4a3-/- mice might involve crosstalk between kidney tubules and the glomerulus and that inhibition of USAG-1 may be a promising therapeutic approach for the treatment of Alport syndrome. PMID: 20197625
    13. Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways PMID: 14623234
    14. reported that ectodin, a secreted bone morphogenetic protein (BMP) inhibitor, is expressed as a "negative" image of enamel knots; proposed that ectodin is critical for robust spatial delineation of enamel knots and cusps PMID: 16179481
    15. Uterine sensitization-associated gene-1 (USAG-1) plays a critical role in the modulation of renoprotective action of bone morphogenetic protein. PMID: 16341262
    16. Expression of USAG-1 mRNA appears to be associated with blastocyst implantation to the luminal epithelium, suggesting that physiological or biochemical contact of the blastocyst to the uterus is required for USAG-1 expression PMID: 17389776
    17. USAG-1 controls the number of teeth in the maxillary incisor region by regulating apoptosis PMID: 17555714
    18. Enhanced BMP signaling results in supernumerary teeth and BMP signaling was modulated by Wnt signaling in the USAG-1 deficient mouse model. PMID: 18329379
    19. minimizing the amount of dental mesenchyme in cultured Sostdc1-deficient incisors causes the formation of additional de novo incisors that resemble the successional incisor development that results from activated Wnt signaling. PMID: 19141669

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Sclerostin family
  • 组织特异性：
    Highly expressed in kidney at renal collecting ducts level and weakly in brain.
  • 数据库链接：

    KEGG: mmu:66042

    STRING: 10090.ENSMUSP00000040230

    UniGene: Mm.43375