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  4. Recombinant Mouse SERTA domain-containing protein 1 (Sertad1)

Recombinant Mouse SERTA domain-containing protein 1 (Sertad1)

  • 中文名称：
    小鼠Sertad1重组蛋白
  • 货号：
    CSB-YP872877MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sertad1重组蛋白
  • 货号：
    CSB-EP872877MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sertad1重组蛋白
  • 货号：
    CSB-EP872877MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sertad1重组蛋白
  • 货号：
    CSB-BP872877MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sertad1重组蛋白
  • 货号：
    CSB-MP872877MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sertad1
  • Uniprot No.：
  • 别名：
    Sertad1; Sei1SERTA domain-containing protein 1; CDK4-binding protein p34SEI1; SEI-1; Transcriptional regulator interacting with the PHD-bromodomain 1; TRIP-Br1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-236
  • 氨基酸序列
    MLSKGLKRKR EEEETMEALS VDSCWLDPSH PAVAQTPPTV ASSSLFDLSV VKLHHSLRQS EPDLRHLVLV VNTLRRIQAS MEPAPVLPPE PIQPPAPSVA DSLLASSDAG LSASMASLLE DLNHIEDLNQ APQPQADEGP PGRSIGGISP NLGALDLLGP ATGCLLDDGL EGLFEDIDTS MYDSELWLPA SEGLKPGPEN GPAKEEPPEL DEAELDYLMD VLVGTQALER PPGPGR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.
  • 基因功能参考文献：
    1. Met has a role in promoting formation of double minute chromosomes induced by Sei-1 in NIH-3T3 murine fibroblasts PMID: 27494853
    2. these data suggest that SERTAD1 acts as a SMAD1 transcriptional co-activator to promote the expression of BMP target genes during mouse cardiogenesis. PMID: 24211589
    3. Sertad1 expression is required is required for developmental neuronal death in the cerebral cortex. PMID: 20237268
    4. conclude that Sei1 plays an important role in pancreatic beta-cells, which supports a functional link between Sei1 and the core cell cycle regulators specifically in the context of the pancreas PMID: 20090907
  • 组织特异性：
    Detected at in testis, lung and, at lower levels, in muscle, liver, spleen, brain and heart.
  • 数据库链接：

    KEGG: mmu:55942

    STRING: 10090.ENSMUSP00000008528

    UniGene: Mm.153684