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  4. Recombinant Mouse Retinol-binding protein 1 (Rbp1)

Recombinant Mouse Retinol-binding protein 1 (Rbp1)

  • 中文名称：
    小鼠Rbp1重组蛋白
  • 货号：
    CSB-YP019480MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rbp1重组蛋白
  • 货号：
    CSB-EP019480MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rbp1重组蛋白
  • 货号：
    CSB-EP019480MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rbp1重组蛋白
  • 货号：
    CSB-BP019480MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rbp1重组蛋白
  • 货号：
    CSB-MP019480MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rbp1
  • Uniprot No.：
  • 别名：
    Rbp1; Crbpi; Rbp-1; Retinol-binding protein 1; Cellular retinol-binding protein; CRBP; Cellular retinol-binding protein I; CRBP-I; mCRBPI
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-135
  • 氨基酸序列
    PVDFNGYWK MLSNENFEEY LRALDVNVAL RKIANLLKPD KEIVQDGDHM IIRTLSTFRN YIMDFQVGKE FEEDLTGIDD RKCMTTVSWD GDKLQCVQKG EKEGRGWTQW IEGDELHLEM RAEGVICKQV FKKVH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytoplasmic retinol-binding protein. Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis.
  • 基因功能参考文献：
    1. genetic deletion of RBP1 and RBP2 did not impair synapse ultrastructure of ribbon-type synapses formed between rod bipolar cells (RBCs) and amacrine type-2 (AII) cells in the mouse retina but dramatically reduced the density of presynaptic Ca(2+) channels, decreased and desynchronized evoked neurotransmitter release PMID: 28874522
    2. RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions. PMID: 27537484
    3. RBP1 expression was reduced in tissue and endometrial stromal cells derived from endometritis lesions versus eutopic endometruim in humans and mice. PMID: 25143356
    4. CrbpI loss disrupts all-trans retinoic acid homeostasis in mammary tissue, resulting in microenvironmental defects similar to those observed at the early stages of tumorigenesis. PMID: 23362116
    5. glucose homeostasis and energy metabolism rely on Rbp1 expression and its moderation of pancreas retinol and of the autacoid 9-cis-retinoic acid. PMID: 21670153
    6. As such, the effects of RBP1 on these processes are mediated through both regulation of Runx2 expression and transcriptional activity. PMID: 20509905
    7. CRBP-I is a cytosolic protein specifically expressed in preadipocytes that regulates adipocyte differentiation in part by affecting PPAR gamma activity. PMID: 20498279
    8. This murine RBP-null model may have relevance to fetal development in human populations with inadequate retinoid intake. PMID: 12663486
    9. Crbp1-/- mice also exhibited increased metabolism of a dose of retinol into retinoic acid, and this increased metabolism was not observed in Crbp1-/-/Adh1-/- mice PMID: 15193143
    10. Data show that while vitamin A-replete retinol binding protein (rbp)-cryptochrome(cry) 1- and 2-knockout mice are light responsive, vitamin A-depleted knockout mice lose most behavioral and molecular responses to light. PMID: 15523112
    11. Epigenetic silencing of cellular CRBPI is associated with nasopharyngeal carcinoma PMID: 15720818

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  • 亚细胞定位：
    Cytoplasm. Lipid droplet.
  • 蛋白家族：
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 数据库链接：

    KEGG: mmu:19659

    STRING: 10090.ENSMUSP00000059749

    UniGene: Mm.279741