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  4. Recombinant Mouse Retinoic acid receptor beta (Rarb)

Recombinant Mouse Retinoic acid receptor beta (Rarb)

  • 中文名称：
    小鼠Rarb重组蛋白
  • 货号：
    CSB-YP019339MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rarb重组蛋白
  • 货号：
    CSB-EP019339MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rarb重组蛋白
  • 货号：
    CSB-EP019339MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rarb重组蛋白
  • 货号：
    CSB-BP019339MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rarb重组蛋白
  • 货号：
    CSB-MP019339MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rarb
  • Uniprot No.：
  • 别名：
    Rarb; Nr1b2; Retinoic acid receptor beta; RAR-beta; Nuclear receptor subfamily 1 group B member 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-482
  • 氨基酸序列
    MSTSSHACPV PAVRGHMTHY PAAPYPLLFP PVIRGLSLPP LHGLHGHPPP SGCSTPSPAS VGQACQRTTG GSQFAASTKW TPSLNAAIET QSTSSEELVP SPPSPLPPPR VYKPCFVCQD KSSGYHYGVS ACEGCKGFFR RSIQKNMIYT CHRDKNCVIN KVTRNRCQYC RLQKCFEVGM SKESVRNDRN KKKKEPSKQE CTESYEMTAE LDDLTEKIRK AHQETFPSLC QLGKYTTNSS ADHRVRLDLG LWDKFSELAT KCIIKIVEFA KRLPGFTGLT IADQITLLKA ACLDILILRI CTRYTPEQDT MTFSDGLTLN RTQMHNAGFG PLTDLVFTFA NQLLPLEMDD TETGLLSAIC LICGDRQDLE EPTKVDKLQE PLLEALKIYI RKRRPSKPHM FPKILMKITD LRSISAKGAE RVITLKMEIP GSMPPLIQEM LENSEGHEPL TPSSSGNIAE HSPSVSPSSV ENSGVSQSPL LQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
  • 基因功能参考文献：
    1. The RARbeta transcriptional targets were particularly enriched for transcripts affected in Huntington's disease. PMID: 27405468
    2. the low expression of RARbeta, may induce the down regulation of p16(INK4a), chronic inflammation and decreased apoptosis and may be involved in vulnerability to HR-HPV and early stage cervical carcinogenesis. PMID: 27207583
    3. Upregulation of Rarb increases the cytotoxic effect of 5-FU on xenografted cholangiocarcinoma tumors. PMID: 27599527
    4. Results found that HPV16 E7 increases RARB mRNA and protein expression both in vitro and in the cervix of young K14E7 transgenic mice suggesting that RARB overexpression is part of the early molecular events induced by the E7 oncoprotein. PMID: 26173416
    5. Chromatin immunoprecipitation assay using RarB as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 and Foxn1 in mice. PMID: 26352270
    6. IL-15 specifically down-regulates RARB expression, and RARB may play a protective role in lung injury caused by smoking or viral infections. PMID: 25923039
    7. RARB hypermethylation was involved in the areca-associated oral carcinogenesis. PMID: 25197641
    8. Report liver RAR-beta mediated response to retinoic acid. PMID: 24833708
    9. Data indicate that all three retinoic acid receptor isoforms RARalha, RARbeta and RARgamma are expressed in naive CD8+ T cells, as well as CD8+ T cells activated for 48 or 72 h. PMID: 24610012
    10. RARbeta is essential for differentiation of ES cells to pancreatic endocrine cells. PMID: 23756134
    11. Retinoic acid receptor beta stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice. PMID: 23430257
    12. Results define PARG as a coactivator regulating chromatin remodeling during retinoic acid receptor-dependent gene expression. PMID: 23102699
    13. RARbeta expression is involved in splenic cell organization as well as in the maintenance of splenic dendritic cell population. PMID: 22546502
    14. Retinoic acid (RA), acting through the RA receptor beta (RAR-beta), inhibits myelin-activated Nogo receptor (NgR) signaling through the transcriptional repression of the NgR complex member Lingo-1. PMID: 21690307
    15. the Rarb region of Mmu14 and Stmn2, but not Cr1 or Clu or Picalm have roles in prion disease PMID: 21151910
    16. a markedly reduced expression of chemokine (C-X-C motif) ligand 12 (Cxcl12) in the stroma of Rarb-null mice is accompanied by a decrease in the CXCL12/chemokine C-X-C receptor 4 (CXCR4)/ErbB2 signaling axis in the tumors PMID: 21187396
    17. histone H3 phosphorylation may be a molecular signature of the activated, retinoid-controlled mRARbeta2 gene promoter PMID: 11897660
    18. Protein Kinase C alpha can influence retinoic acid signaling by altering the stability of Retinoic Acid Receptor beta protein without directly phosphorylating this receptor. PMID: 12000751
    19. Effects of retinoic acid receptor beta (RARbeta) and retinoid X receptor alpha (RXRalpha) on the regulation of the alpha(2)(I) collagen promoter. PMID: 12054477
    20. the number, migration, and terminal fate of the cardiac neural crest is normal in mutant embryos; however, the specific function of these cells in forming the aorticopulmonary septum is impaired PMID: 12204252
    21. After transduction of retinoic acid receptor beta2, prolific neurite outgrowth occurs in adult rodent spinal cord. PMID: 12235288
    22. RARbeta plays a minimal role in the initial differentiation of otic placode derivatives PMID: 12464434
    23. Data suggest that craniofacial abnormalities characteristic of retinoic acid embryopathy are mediated through ectopic activation of retinoic acid receptor beta/ retinoid x receptor heterodimers. PMID: 12668623
    24. Aberrant methylation of RAR-beta is an early and common alteration in murine lung tumors induced by several environmentally relevant exposures. PMID: 14656941
    25. crystallization of the heterodimeric complex of RARbeta and RXRalpha ligand-binding domains in the active conformation PMID: 15159591
    26. results reveal molecular and structural features that impact on the ligand-dependent interaction of the RAR/RXR heterodimer with nuclear receptor coactivators PMID: 15528208
    27. RARbeta2 transcript variants with short 5'-UTRs were identified in both normal and malignant breast epithelial cells; they may serve as major transcripts for RARbeta2 protein translation. PMID: 15558014
    28. a new molecular link, completing a feedback circuit between Rarb, Hoxb4 and Hoxd4 PMID: 15634700
    29. Results suggest that deletion of the retinoic acid receptor beta gene impairs the formation of the distal airspaces during the postnatal phase of lung maturation in mice via a pathway that may involve PDGF-A. PMID: 15635054
    30. The differential expression pattern of RARbeta isoforms in the developing striatum may provide an anatomical basis for differential gene regulation by RARbeta signaling PMID: 15778968
    31. RARalpha, beta, and gamma isotypes each have specific and distinct roles during the initial stages of neural differentiation of PCC7 cells PMID: 15831518
    32. Our studies show that both GGOH and GGPP, independent of protein prenylation, stimulate osteoclastic bone resorption via RAR, probably via metabolism into GGA. PMID: 16165408
    33. findings demonstrate in the mouse that the gene encoding the retinoic acid receptor beta determines the contribution of delta oscillations to the sleep EEG PMID: 16210540
    34. in RAC65 cells, RARbeta 2 is transcriptionally repressed as well as Cyp26a1 PMID: 16261163
    35. phosphoinositide 3-kinase/Akt signaling pathway, an important modulator of cellular survival, has thus a direct impact on cellular retinoid sensitivity, and its deregulation may be the triggering event in retinoid resistance of cancer cells PMID: 16613989
    36. Sonic hedgehog (Shh) is a downstream target of the RARbeta2 signalling pathway as it is expressed in the injured DRG of wild-type but not RARbeta null mice. PMID: 16860305
    37. The ablation of all RXR (alpha, beta and gamma isotypes) in Sertoli cells does not recapitulate the phenotype generated upon ablation of all three retinoic acid receptors. PMID: 17124491
    38. Localization revealed epithelial-mesenchymal interactions, differentiation differences within the retinoic acid biosynthesis and signaling pathway, and observations on nuclear versus cytoplasmic locations of Crabp2 and RA receptors (alpha, beta, gamma). PMID: 17363914
    39. The change of RAR-beta2 expression between 9.5-11.5 days post-conception coincided with the time of tracheo-esophageal separation of the foregut. PMID: 18026738
    40. RARbeta signaling thus plays a crucial role in setting up striatal compartments that may engage in neural circuits of psychomotor control. PMID: 18443282
    41. Results suggest that although retinoic acid receptor beta and active glycogen synthase kinase 3 are required for retinoic acid -induced adipogenesis, they might be acting through a Wnt pathway-independent mechanism. PMID: 18690793
    42. retinoic acid receptor-beta2 has a role in suppression of cyclooxygenase-2 in esophageal neoplasms PMID: 19258542

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Nuclear hormone receptor family, NR1 subfamily
  • 数据库链接：

    KEGG: mmu:218772

    STRING: 10090.ENSMUSP00000067694

    UniGene: Mm.259318