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  4. Recombinant Mouse Renin receptor (Atp6ap2), partial

Recombinant Mouse Renin receptor (Atp6ap2), partial

  • 中文名称：
    Recombinant Mouse Renin receptor(Atp6ap2),partial,Yeast
  • 货号：
    CSB-YP883945MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Renin receptor(Atp6ap2),partial,Yeast
  • 货号：
    CSB-EP883945MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Renin receptor(Atp6ap2),partial,Yeast
  • 货号：
    CSB-EP883945MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Renin receptor(Atp6ap2),partial,Yeast
  • 货号：
    CSB-BP883945MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Renin receptor(Atp6ap2),partial,Yeast
  • 货号：
    CSB-MP883945MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Atp6ap2; Atp6ip2Renin receptor; ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; Renin/prorenin receptor) [Cleaved into: Renin receptor extracellular fragment; Renin receptor cytoplasmic fragment]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (v-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission.
  • 基因功能参考文献：
    1. We conclude that ATP6AP2 is necessary for cell division, cell cycle progression and mitosis. ATP6AP2 also inhibits ciliogenesis, thus promoting proliferation and preventing differentiation PMID: 28215051
    2. the missense mutations in ATP6AP2 lead to impaired V-ATPase assembly and subsequent defects in glycosylation and autophagy. PMID: 29127204
    3. Kidney collecting duct PRR contributes to renal function and blood pressure responses during chronic ANG II infusion by enhancing renin activity, increasing ANG II, and activating ENaC in the distal nephron segments. PMID: 28814438
    4. These results suggest that in vivo the regulation of macroautophagy depends not only on v-H(+)-ATPase-mediated regulation of MTORC1. PMID: 28129027
    5. Ureter bud PRR performs essential functions during UB branching and collecting duct morphogenesis via control of a hierarchy of genes that control UB branching and terminal differentiation of the collecting duct cells. PMID: 28031172
    6. ATP6AP2 disruption leads to cognitive impairment and neurodegeneration, mimicking aspects of the neuropathology associated with ATP6AP2 mutations in humans. PMID: 26376863
    7. These findings demonstrate a cell-autonomous requirement for the PRR within nephron progenitors for progenitor maintenance. PMID: 26658320
    8. Atp6ap2 may form a complex with H+-ATPases in proximal tubule and intercalated cells but that prorenin has no acute effect on H+-ATPase activity in intercalated cells. PMID: 26824839
    9. a novel GLP1R Interacting Protein ATP6ap2 PMID: 26272612
    10. Data suggest that high glucose (as in hyperglycemia) decreases autophagy and increases apoptosis in podocytes via activation of (pro)renin receptor (Atp6ap2) and PI3K/Akt/mTOR signaling pathway. PMID: 26081285
    11. ANG II acts via AT1R to upregulate PRR expression both in cultured cells and in DOCA-salt hypertensive mice by increasing CREB binding to the PRR promoter. PMID: 25994957
    12. nephron PRR may be important in water regulation by modulating the AVP/V2R/AQP2 pathway PMID: 25995108
    13. the v-ATPase ATP6AP2 does not appear to have a fusion-promoting role in the formation of phagolysosomes PMID: 25903133
    14. ATPase H+ transporting lysosomal accessory protein 2 is critical for granule cell fate and morphogenesis. PMID: 25810528
    15. These results suggest that the (P)RR is essential for cell survival and downregulation of vascular inflammation in murine vascular smooth muscle cells through maintaining normal function of the vacuolar H(+)-ATPase. PMID: 24830537
    16. Expression of (pro)renin receptor (PRR) in mIMCD (mouse inner medullary collecting duct) cells is regulated by the GSK-3beta-NFAT5- SIRT-1 signaling pathway. PMID: 24990896
    17. DJ-1 protein regulates the expression of renal PRR through H2O2-mediated epigenetic modification. PMID: 25463323
    18. The prorenin receptor pathway is involved in the development of insulin resistance PMID: 25074986
    19. Data (including data from studies in transgenic mice) suggest that increased expression of PRR/ATP6AP2 ([pro]renin receptor)--alone or associated with increased renin--is not sufficient to induce cardiac or renal disease/hypertrophy. PMID: 25046440
    20. The extracellular domain (ECD) and transmembrane domain (TM) of ATP6AP2 were indispensable for the biogenesis of active V-ATPase. PMID: 24223829
    21. Studies suggested that the complete deletion of (P)RR was lethal. PMID: 24400720
    22. Neuron-specific PRR knockout prevents the development of deoxycorticosterone acetate-salt-induced hypertension, possibly through diminished angiotensin II formation. PMID: 24246383
    23. Our present data revealed the novel function of Atp6ap2/(P)RR required for laminar formation during retinal development PMID: 24305829
    24. PRR present in the ureteric bud (UB) epithelia performs essential functions during UB branching morphogenesis. PMID: 23704941
    25. global null deletion of Ceacam1 caused an increase in blood pressure with increased renin-angiotensin system activation together with upregulation of prorenin receptor via PI3K-Akt activation of CREB-1, ATF-1, ATF-2, and NF-kappaB p65. PMID: 23734002
    26. The results indicate that (P)PR is mainly expressed by adult neurons in the hippocampus as well as in late stages of adult neurogenesis within the hippocampus PMID: 23357953
    27. PRR-mediated angiotensin II-independent ROS formation is associated with activation of the MAPK/ERK1/2 and PI3/Akt signaling pathways and up-regulation of mRNA level of NOX 2 and NOX4 isoforms in neuronal cells. PMID: 23516464
    28. Data indicate that (pro)renin receptor knockdown in the brain attenuates angiotensin II-dependent hypertension and is associated with a decrease in sympathetic tone and an improvement of the baroreflex sensitivity. PMID: 22526255
    29. Sodium depletion enhances renal expression of (pro)renin receptor via cyclic GMP-protein kinase G signaling pathway. PMID: 22203739
    30. increased expression of podocyte COX-2 predisposes to diabetic glomerular injury and the (pro)renin receptor may be one mediator for this increased susceptibility to injury PMID: 21737546
    31. ATP6AP2 acts as a prorenin receptor exerting a RAS-related function as the vacuolar H+-ATPase-associated protein; cardiomyocyte-specific ablation of Atp6ap2 results in lethal heart failure. PMID: 20570919
    32. Results indicate that activation of angiotensin II type 2 receptors is responsible for reduced prorenin/renin receptor expression in response to angiotensin II and high glucose in glomerular mesangial cells and renal tissue of streptozocin-treated rats. PMID: 19879325
    33. The findings suggest that the expression of (P)RR is increased in the hearts and kidneys of rats with heart failure, and that (P)RR may contribute to heart failure. PMID: 19765626
    34. Defined the role of (pro)renin receptor in choroidal neovascularization (CNV) generation;(Pro)renin receptor blockade suppressed ERK activation & the production of MCP-1 & VEGF, but not ICAM-1, VEGFR-1 or VEGFR-2, in AT1-R-deficient mice with CNV. PMID: 18974301
    35. results show that (P)RR is expressed in mouse brain and suggest that the XLMR and epilepsy phenotype might result from a dominant-negative effect of the Delta4-(P)RR protein PMID: 19474391

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Lysosome membrane. Cytoplasmic vesicle, autophagosome membrane. Cell projection, dendritic spine membrane. Cell projection, axon. Endosome membrane.
  • 组织特异性：
    Expressed in glutamatergic and GABAergic neurons with highest levels in the cortex, the hippocampus, the medial habenular nucleus, the cerebellum, the medulla and the olfactory bulb (at protein level).
  • 数据库链接：

    KEGG: mmu:70495

    STRING: 10090.ENSMUSP00000033313

    UniGene: Mm.25148