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  4. Recombinant Mouse Ras-related C3 botulinum toxin substrate 3 (Rac3)

Recombinant Mouse Ras-related C3 botulinum toxin substrate 3 (Rac3)

  • 中文名称：
    小鼠Rac3重组蛋白
  • 货号：
    CSB-YP019249MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rac3重组蛋白
  • 货号：
    CSB-EP019249MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rac3重组蛋白
  • 货号：
    CSB-EP019249MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rac3重组蛋白
  • 货号：
    CSB-BP019249MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rac3重组蛋白
  • 货号：
    CSB-MP019249MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Rac3; Ras-related C3 botulinum toxin substrate 3; EC 3.6.5.2; p21-Rac3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-189
  • 氨基酸序列
    MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPHTPI LLVGTKLDLR DDKDTIERLR DKKLAPITYP QGLAMAREIG SVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKPGKKC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.
  • 基因功能参考文献：
    1. Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. PMID: 29061650
    2. The results of this study show that Rac3 have a roles in the formation of GABAergic circuits, as highlighted by the differential effects of their deletion on the late maturation of specific populations. PMID: 26582364
    3. This study showed that in the absence of both Rac1 and rac3, the embryonic migration of medial ganglionic eminence-derived interneurons is further impaired. PMID: 24626607
    4. This study demonistrated that Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons in mice. PMID: 23258346
    5. Rac1b forms a complex with NADPH oxidase and promotes the production of reactive oxygen species, expression of Snail, and activation of the epithelial-mesenchymal transition program. PMID: 22918955
    6. Activation of epithelial-mesenchymal transition by MMP-induced expression of Rac1b gave rise to lung adenocarcinoma. PMID: 22786680
    7. Rac1 and Rac3 redundantly regulate many aspects of inner ear morphogenesis, including cell adhesion, cell proliferation, cell death and cell movements. PMID: 22182523
    8. Rac1 and Rac3 GTPases participate in the normal development of hilar mossy cells. PMID: 21949760
    9. results support a role for neuronal Rac1 and Rac3 in dictating proper lymphoid organ development, and suggest the existence of lymphoid-extrinsic mechanisms linking neural defects to the loss of immune-competence PMID: 21469092
    10. These defects result from increased RhoA/ROCK/myosin II activity and blockade of Rac1 signaling. PMID: 21396893
    11. The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin PMID: 20395297
    12. data implicate Rac3 in neuronal differentiation, and support a specific role of this GTPase in actin-mediated remodelling of Purkinje cell neuritic terminals at time of synaptogenesis PMID: 14622142
    13. The generation and characterization of Rac3 knockout mice are described. PMID: 15964829
    14. The role of Rac3 was studied in Bcr-Abl-caused lymphoblastic leukemia. PMID: 15964830
    15. In this study find that Rac3 knockout mice do not show defects in spatial reference memory assessed with water maze task, but they show a reduced behavioral flexibility to novel situations. PMID: 17889944
    16. both Rac1 and Rac3 are important for the development of the nervous system, wherein they play complementary roles during late stages of neuronal and brain development. PMID: 19126596

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  • 亚细胞定位：
    Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Small GTPase superfamily, Rho family
  • 数据库链接：

    KEGG: mmu:170758

    STRING: 10090.ENSMUSP00000018156

    UniGene: Mm.34008