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  4. Recombinant Mouse Ran-binding protein 3 (Ranbp3)

Recombinant Mouse Ran-binding protein 3 (Ranbp3)

  • 中文名称：
    小鼠Ranbp3重组蛋白
  • 货号：
    CSB-YP875135MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ranbp3重组蛋白
  • 货号：
    CSB-EP875135MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ranbp3重组蛋白
  • 货号：
    CSB-EP875135MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ranbp3重组蛋白
  • 货号：
    CSB-BP875135MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ranbp3重组蛋白
  • 货号：
    CSB-MP875135MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ranbp3
  • Uniprot No.：
  • 别名：
    Ranbp3; Ran-binding protein 3; RanBP3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-491
  • 氨基酸序列
    MADLANEEKP AVAPSVFVFQ KDKGQKRSAG SSSPEAGEDS DHEDGNYCPP VKRERTSSLT HSEEKSSGFR LKPPTLIHGQ APSAGLPSQK PREQQRGVLR PAVLQAPQPK VLSQTVPSSG TNGVSMPADC TGPATSVSPE NLTQRSPSES AEETHTLEEK VPQKTPHGTS EEGHCEEEQA APQAFVFGQN LRDRVKLMNE NASVADVDSA AHPSSETPSA TNYFLQYISS SADNATHSAD NSTKFVFGQN MSERVLSPPK LNEANSDTSR ETTHAQSGSE SSSQEAAPKK ESLAESAAAY TKATAWTCLL EKVEVITGEE AESNVLQIQC KLFVFDKTSQ SWVERGRGLL RLNDMASTDD GTLQSRLVMR TQGSLRLILN TKLWAQMQMD KASEKSIRIT ATDAEDQGVK VFLISASSKD TGQLYAALHH RILALRSRAE QEQEAKAPPP EPGATRATEE EDSDEDAVLA PSGVTGAGTG DEGDGQAPGS T
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
  • 基因功能参考文献：
    1. Protein phosphatase PPM1A regulates the nuclear export of Smad2/3 through targeting nuclear exporter RanBP3. PMID: 21960005
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 数据库链接：

    KEGG: mmu:71810

    STRING: 10090.ENSMUSP00000002445

    UniGene: Mm.29608