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  4. Recombinant Mouse RNA polymerase II elongation factor ELL2 (Ell2)

Recombinant Mouse RNA polymerase II elongation factor ELL2 (Ell2)

  • 中文名称：
    小鼠Ell2重组蛋白
  • 货号：
    CSB-YP667578MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ell2重组蛋白
  • 货号：
    CSB-EP667578MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ell2重组蛋白
  • 货号：
    CSB-EP667578MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ell2重组蛋白
  • 货号：
    CSB-BP667578MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ell2重组蛋白
  • 货号：
    CSB-MP667578MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ell2
  • Uniprot No.：
  • 别名：
    Ell2RNA polymerase II elongation factor ELL2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-639
  • 氨基酸序列
    MAAGGAAGLR EEQRYGLACG RLGQDNITVL HVKLTETAIR ALETYQSHKN LIPFRPSIQF QGLQGLMKIP KNDPFNEVQN FNFYLSNVGR DNPQGSFDCI QQTLSSSGAS QLNCLGFIQD KITVCATNDS YQMTRERMTQ AEEESRNRST KVIKPGGPYV GKRVQIRKAP QAISDTVPER KRSTPMNPAN TIRKMHSGNS VSQRPYRDRV IHLLALKAYK KPELLARLQK DGVNQKDKNS LGAILQQVAN LNPKDLSYTL KDYVFKELQR DWPGYSETDR QTLDLVLSRK LNPSQNASTS RSESPLCSSK DAASSPQKRP LDSDFIDPLM NKKARISHLT NRVPPTLNGY LNPTSEKSCA GLLPPPAAAA IPTLSPLPST HLPVSNPPQT VNSNSNSPST PEGLGTQDLP VDSFSQNGSI FEDQQEKYTS RTCLETLPPS SALLKCPKPM EEEHPVSHKK SKKKSKKHKE KDQIKKLDIE TMEEKEEDLQ REETAKLSNA SPNPNEGVKE GCTASMEPSS ALELPDYLIK YIAIVSYEQR QNYKDDFNAE YDEYRALHAR METVARRFIK LDAQRKRLSP GSKEYQNVHE EVLQEYQKIK QSSPNYHEEK YRCEYLHNKL AHIKRLIGEF DQQQAESWH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.
  • 基因功能参考文献：
    1. These results suggest that ELL2 and its pathway genes likely play an important role in the development and progression of prostate cancer. PMID: 28870994
    2. ELL2 is important for many aspects of Ab secretion, XBP1 expression, and the unfolded protein response. PMID: 25238757
    3. Deletion of the Ell2 gene in mice results in loss of Ig secretion from plasma cells and reduced expression of a number of other genes involved in secretion and the unfolded protein response like XBP1, OcaB (BOB1, Pou2af1), cyclin B2 and Ig light chain PMID: 25238757
    4. ELL2 enhanced both polyadenylation and exon skipping with the gene encoding the immunoglobulin heavy-chain complex (Igh) and reporter constructs PMID: 19749764
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ELL/occludin family
  • 数据库链接：

    KEGG: mmu:192657

    STRING: 10090.ENSMUSP00000001583

    UniGene: Mm.21288