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  4. Recombinant Mouse RNA binding protein fox-1 homolog 1 (Rbfox1)

Recombinant Mouse RNA binding protein fox-1 homolog 1 (Rbfox1)

  • 中文名称：
    小鼠Rbfox1重组蛋白
  • 货号：
    CSB-YP867494MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rbfox1重组蛋白
  • 货号：
    CSB-EP867494MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rbfox1重组蛋白
  • 货号：
    CSB-EP867494MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rbfox1重组蛋白
  • 货号：
    CSB-BP867494MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rbfox1重组蛋白
  • 货号：
    CSB-MP867494MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rbfox1
  • Uniprot No.：
  • 别名：
    Rbfox1; A2bp; A2bp1; Fox1; MNCb-3035; RNA binding protein fox-1 homolog 1; Ataxin-2-binding protein 1; Fox-1 homolog A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-396
  • 氨基酸序列
    MNCEREQLRG NQEAAAAPDT MAQPYASAQF APPQNGIPAE YTAPHPHPAP EYTGQTTVPD HTLNLYPPTQ THSEQSADTS AQTVSGTATQ TDDAAPTDGQ PQTQPSENTE SKSQPKRLHV SNIPFRFRDP DLRQMFGQFG KILDVEIIFN ERGSKGFGFV TFENSADADR AREKLHGTVV EGRKIEVNNA TARVMTNKKT VNPYTNGWKL NPVVGAVYSP DFYAGTVLLC QANQEGSSMY SGPSSLVYTS AMPGFPYPAA TAAAAYRGAH LRGRGRTVYN TFRAAAPPPP IPAYGGVVYQ DGFYGADIYG GYAAYRYAQP TPATAAAYSD SYGRVYAADP YHHTLAPAPT YGVGAMNAFA PLTDAKTRSH ADDVGLVLSS LQASIYRGGY NRFAPY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.
  • 基因功能参考文献：
    1. Study shows that Rbfox1-isoform1 plays an important role in neuronal migration and synapse network formation during corticogenesis. Defects in these critical processes may induce structural and functional defects in cortical neurons, and consequently contribute to the pathophysiology of neurodevelopmental disorders with RBFOX1 abnormalities. PMID: 27481563
    2. Upon picrotoxin treatment, Rbfox1 expression was downregulated by miR-129-5p, thereby allowing the repression of Atp2b4 and Dcx. PMID: 28487411
    3. Cytoplasmic Rbfox1 target mRNAs were enriched in genes involved in cortical development and autism PMID: 26687839
    4. Rbfox1 regulates RNA splicing required for skeletal muscle structure and function. PMID: 25575511
    5. Fox-1, expressed specifically in the neural cell stage, promoted Mef2c exon beta inclusion via the GCAUG. PMID: 20141540
    6. The results suggest that in neuronal tissues A2BP1 plays important roles, which are regulated in a spatiotemporal manner. PMID: 23918472
    7. our results suggest that a component of FSHD pathogenesis may arise by over-expression of FRG1, reducing Rbfox1 levels and leading to aberrant expression of an altered Calpain 3 protein through dysregulated splicing PMID: 23300487
    8. Fox-1 splices mRNAs encoding proteins important in synaptic transmission and membrane excitation. PMID: 23027929
    9. The splicing regulator Rbfox1 controls neuronal excitation in the mammalian brain. PMID: 21623373
    10. These data indicate that A2BP1 mutations may clinically affect very selective forebrain neuron types from early periods of development. PMID: 21346316
    11. These results demonstrate that the Fox protein family is playing a key role in tuning the properties of CaV1.2 calcium channels during neuronal development. PMID: 19564422
    12. Fox-1/Ataxin 2-Binding Protein 1 (A2BP1), a protein implicated in a variety of neurological diseases, can counteract the effects of chronic depolarization on splicing PMID: 19762510

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Predominantly nuclear.
  • 组织特异性：
    Detected in brain (at protein level). Detected in heart, brain, neurons, skeletal muscle and embryo.
  • 数据库链接：

    KEGG: mmu:268859

    STRING: 10090.ENSMUSP00000049970

    UniGene: Mm.370334