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  4. Recombinant Mouse RAD50-interacting protein 1 (Rint1)

Recombinant Mouse RAD50-interacting protein 1 (Rint1)

  • 货号：
    CSB-YP804889MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP804889MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP804889MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP804889MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP804889MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rint1
  • Uniprot No.：
  • 别名：
    Rint1; RAD50-interacting protein 1; RAD50 interactor 1; RINT-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-792
  • 氨基酸序列
    MLAADDIGEV PAAPCCPESG DETKNTDVKS DVNTAAPAGS EQLSQGGSDD ALLSYVSAFI EKEVGSDLKS LKTLGKLIEQ MTESKVKLEE QVLTISSEIP KRIQSALKDA EESKQLLDEF LEQEAPLFSS ISSHLLMAQP WMDDLGAMIT QMEEIERHLA YLKWVSQTEE LSDNIQQYLM TNSVPEAASL LVTMTELDIQ LQESSCTHLL SFMRATVKFW HKILKDKLTS DFEEVLAQLH WPFTSHTQSQ TVGGSRPAGT PELYSSLDTL FCQLLKLQAS DELLTEPKQL PEKYCLPASP PVTLPIQVML APLQKRFRYH FRGSRQTNVM SKPEWYLAQV LMWIGNHTQF LDEKIQPILD KVGSAVNARL EFSRGLVMLI LEKLASDIPC LLYDDSLFCH LVDEVLLFER ELHTVHGYPS TFASCMHILS EETCFQRWLT VERKFALQKM DSMLSSEAAW VSQYKDISDV DEMKVPDCAE VFMTLLLVIT DRYKNLPTAS RKLQFLELQK DLVDDFRIRL TQVMKEETRA ALGFRYCAIL NAVNYISAVL ADWADNVFFL QLQQAALEVF AENNVLSKLQ LGQLASMESS VFDDMINLLE RLKLDMLTRQ VDHVFREVKD SAKLYKKERW LSLPSQSEQA VMSLSSSACP LLLTLRDRLL QLEQQLCFSL FRIFWQMLAE KLDLYIYQEI ILANHFNEGG AAQLQFDMTR NLFPLFSHYC KRPENYFKHV KEACIILNLN IGSALLLKDV LQSVSEHIPA TAALNEVGVY KLAQQDVEIL LNLRTNWPNT GK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control.
  • 基因功能参考文献：
    1. RINT1 has a role as a multitasking protein with roles in genomic stability, ER homeostasis, and autophagy PMID: 27367497
    2. these data are more consistent with the hypothesis that RINT1 functions as an oncogene rather than a tumor suppressor gene in the context of colorectal cancer. PMID: 28264000
    3. A crucial role of Rint1 in vivo in genomic stability maintenance, as well as in prevention of endoplasmic reticulum stress and autophagy. PMID: 26383973
    4. These findings suggest that RINT-1 serves as a novel tumor suppressor essential for maintaining the dynamic integrity of the Golgi apparatus and the centrosome, a prerequisite to their proper coordination during cell division. PMID: 17470549
  • 亚细胞定位：
    Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族：
    RINT1 family
  • 数据库链接：

    KEGG: mmu:72772

    STRING: 10090.ENSMUSP00000030852

    UniGene: Mm.133300