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  4. Recombinant Mouse Putative RNA-binding protein 3 (Rbm3)

Recombinant Mouse Putative RNA-binding protein 3 (Rbm3)

  • 中文名称：
    小鼠Rbm3重组蛋白
  • 货号：
    CSB-YP019420MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rbm3重组蛋白
  • 货号：
    CSB-EP019420MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rbm3重组蛋白
  • 货号：
    CSB-EP019420MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rbm3重组蛋白
  • 货号：
    CSB-BP019420MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rbm3重组蛋白
  • 货号：
    CSB-MP019420MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rbm3
  • Uniprot No.：
  • 别名：
    Rbm3; RNA-binding protein 3; RNA-binding motif protein 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-153
  • 氨基酸序列
    MSSEEGKLFV GGLNFNTDEQ ALEDHFSSFG PISEVVVVKD RETQRSRGFG FITFTNPEHA SDAMRAMNGE SLDGRQIRVD HAGKSARGSR GGAFGGRGRS YSRGGGDQGY GSGRYDSRPG GYGYGYGRSR DYSGSQGGYD RYSGGNYRDN YDN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation.
  • 基因功能参考文献：
    1. RTN3 expression is a mediator of RBM3-induced neuroprotection, controlled by novel mechanisms of escape from translational inhibition on cooling. PMID: 28238655
    2. RBM3 regulates osteoblast differentiation through the ERK signaling pathway. PMID: 29505791
    3. deficient synapse regeneration, mediated at least in part by failure of the RBM3 stress response, contributes to synapse loss throughout the course of neurodegenerative disease PMID: 25607368
    4. Moderate hypothermia resulted in significant up-regulation of both RBM3 and CIRP mRNA in murine organotypic hippocampal slice cultures PMID: 23415676
    5. Up-regulation of neuronal RBM3 apparently accounts for a substantial proportion of hypothermia-induced neuroprotection in the developing postnatal murine brain. PMID: 21527344
    6. Overexpression of RBM3 in skeletal muscle myoblasts is associated with an increase in cell survival through inhibitory actions on both apoptosis and necrosis. PMID: 21593448
    7. Rbm3(-/-) mouse embryonic fibroblasts have markedly increased number of G2-phase cells, suggesting a hitherto unknown role of RBM3 in the G2-phase control. PMID: 21684257
    8. Data suggest that both Rbm3 and microRNAs are part of a homeostatic mechanism that regulates global levels of protein synthesis under normal and cold-stress conditions. PMID: 15684048
    9. the RNA stabilizing and translation regulatory protein RBM3 is a novel proto-oncogene that induces transformation when overexpressed and is essential for cells to progress through mitosis. PMID: 18427544

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell projection, dendrite.
  • 数据库链接：

    KEGG: mmu:19652

    STRING: 10090.ENSMUSP00000038964

    UniGene: Mm.128512