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  4. Recombinant Mouse Purkinje cell protein 2 (Pcp2)

Recombinant Mouse Purkinje cell protein 2 (Pcp2)

  • 中文名称：
    小鼠Pcp2重组蛋白
  • 货号：
    CSB-YP017635MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pcp2重组蛋白
  • 货号：
    CSB-EP017635MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pcp2重组蛋白
  • 货号：
    CSB-EP017635MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pcp2重组蛋白
  • 货号：
    CSB-BP017635MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pcp2重组蛋白
  • 货号：
    CSB-MP017635MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pcp2
  • Uniprot No.：
  • 别名：
    Pcp2; Pcp-2; Purkinje cell protein 2; Protein PCD-5; Purkinje cell-specific protein L7
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-120
  • 氨基酸序列
    MAGSPDQEGF FNLLTHVQGD RMEEQRCSLQ AGPGQNPESQ GGPAPEMDNL MDMLVNTQGR RMDDQRVTVN SLPGFQPIGP KDGMQKRPGT LSPQPLLTPQ DPAALSFRRN SSPQPQTQAP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May function as a cell-type specific modulator for G protein-mediated cell signaling.
  • 基因功能参考文献：
    1. A novel Pcp2 transcript is particular to mouse cerebellar Purkinje cells and retinal bipolar neurons. PMID: 27525924
    2. Study describes alternative splicing of the pcp2/L7 gene; biochemical properties of short and long form differ PMID: 24092530
    3. The results of this study showed that L7-PP2B mice, which suffer from impaired intrinsic plasticity and synaptic potentiation of their Purkinje cells. PMID: 24478374
    4. This study characterized the Cre-positive retinal ganglion cells in a PCP2 (Purkinje cell protein 2)-cre mouse line. We found that all of the Cre-positive retinal ganglion cells were bistratified retinal ganglion cells. PMID: 23224947
    5. both L7 genotype and sex contribute to both acquisition and extinction of fear conditioning is affected in Pcp2(L7) mutants PMID: 22528962
    6. Two mRNA forms predict two forms of the L7/Pcp-2 protein, which are both highly conserved across species.In mouse both mRNA forms are detectable in dendrites but their relative proportions change during development. PMID: 12399102
    7. colocalization and association of Galpha(o) and Pcp2 in cerebellum suggest a functional role in regions of synaptic activity. PMID: 12424730
    8. BAC/Cre transgenic mice have exclusive Cre expression in Purkinje and bipolar cells PMID: 15354293
    9. effect on expression of cre recombinase PMID: 15883005
    10. Pcp2 induces differentiation in PC12 cells, in part through Gbetagamma-mediated Ras and p38 MAPK activation and suggest the potential for similar signalling mechanisms in Purkinje cells. PMID: 15948714
    11. We conclude that PCP2 facilitates cation channels closure in the dark, shortens the rise time of the light response directly, and accelerates the decay time indirectly via the inhibitory network. PMID: 18768681
    12. Results suggest that the Pcp2(L7) protein acts as a sensorimotor damper that modulates time- and sense-dependent changes in motor responses. PMID: 18930827

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  • 组织特异性：
    Cerebellum (Purkinje cells) and retinal bipolar neurons.
  • 数据库链接：

    KEGG: mmu:18545

    STRING: 10090.ENSMUSP00000121079

    UniGene: Mm.440882