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  4. Recombinant Mouse Pulmonary surfactant-associated protein B (Sftpb)

Recombinant Mouse Pulmonary surfactant-associated protein B (Sftpb)

  • 中文名称：
    小鼠Sftpb重组蛋白
  • 货号：
    CSB-YP021173MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sftpb重组蛋白
  • 货号：
    CSB-EP021173MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sftpb重组蛋白
  • 货号：
    CSB-EP021173MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sftpb重组蛋白
  • 货号：
    CSB-BP021173MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sftpb重组蛋白
  • 货号：
    CSB-MP021173MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sftpb
  • Uniprot No.：
  • 别名：
    Sftpb; Sftp3; Pulmonary surfactant-associated protein B; SP-B; Pulmonary surfactant-associated proteolipid SPL(Phe)
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    192-270
  • 氨基酸序列
    LPIPLPFCW LCRTLIKRVQ AVIPKGVLAV AVSQVCHVVP LVVGGICQCL AERYTVLLLD ALLGRVVPQL VCGLVLRCST
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
  • 基因功能参考文献：
    1. Surfactant protein B suppresses lung cancer progression by inhibiting secretory phospholipase A2 activity and arachidonic acid production. PMID: 28743125
    2. These data provided a plausible mechanism linking maternal vitamin D deficiency with altered postnatal lung function. PMID: 27121020
    3. Surfactant protein B had decreased levels in influenza A virus PR8-infected cells, which was confirmed by immunoblotting and immunofluorescence assays. PMID: 25965799
    4. macrophages participate in the repression of SFTPB expression by LPS, and that macrophage-released cytokines (including TNF) regulate the transcription factor CEBPB PMID: 23590297
    5. ErbB4 regulates the expression of surfactant protein B in fetal lung maturation, helping to prepare for the fetal-neonatal transition. PMID: 21317380
    6. The stimulatory effects of estrogen on Sftpb are under transcriptional control of ErbB4. PMID: 21777626
    7. SP-B contributes to innate host defense of the lung by supplementing the nonoxidant antimicrobial defenses of alveolar macrophages PMID: 20007532
    8. DNA methylation and chromatin modifications cooperate with Nkx2-1 to regulate Sftpb gene cell specific expression. PMID: 19906647
    9. formation of the intersubunit disulfide bridge is not critical for SP-B function PMID: 12133857
    10. The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice. PMID: 12225952
    11. This protein inhibits endotoxin-induced lung inflammation. PMID: 12594064
    12. Reduction of alveolar SP-B content causes surfactant dysfunction and respiratory failure, indicating that SP-B is required for postnatal lung function. PMID: 12639841
    13. SP-B expression is regulated by PPARgamma in the lung PMID: 12829715
    14. napsin, cathepsin H, and at least one other enzyme are involved in maturation of the biologically active SP-B peptide PMID: 14766755
    15. Results indicate that hypoxia-induced mitogenic factor induces surfactant protein B and C production in mouse lungs and cell lines via activation of phosphatidylinositol 3-kinase/Akt and ERK1/2 mitogen-activated protein kinases. PMID: 16166744
    16. absence of HO-1 in the lung parenchyma, not in bone marrow-derived inflammatory cells, was responsible for enhanced SP-B downregulation and severe physiologic lung dysfunction PMID: 16309574
    17. Via promoter mutation analysis, adjacent TTF-1 binding sites within the proximal promoter region of SP-C were found to be essential for TTF-1/TAP26-enhanced SP-C promoter activity. PMID: 16630564
    18. SP-B controls surface tension by forming a surfactant phospholipid film that regulates shape and nonspecific phagocytic activity of alveolar macrophages on the alveolar surface. PMID: 16632521
    19. ABCA3 is necessary for lamellar body biogenesis, surfactant protein-B processing, and lung development late in gestation. PMID: 17540762
    20. Three novel Sp1 binding motifs were identified in the mouse SP-B promoter. PMID: 19096034
    21. Results support the idea that maintenance of surfactant-associated protein B expression is critical to survival during acute lung injury. PMID: 19131640
    22. The surface tension-lowering properties of Sftpb play an important role in the regulation of pulmonary vascular perfusion. PMID: 19202005
    23. Maintaining Sftpb is critical to survival during acute lung injury PMID: 19131640

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  • 亚细胞定位：
    Secreted, extracellular space, surface film.
  • 数据库链接：

    KEGG: mmu:20388

    STRING: 10090.ENSMUSP00000066805

    UniGene: Mm.46033