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  4. Recombinant Mouse Proto-oncogene FRAT1 (Frat1)

Recombinant Mouse Proto-oncogene FRAT1 (Frat1)

  • 中文名称：
    小鼠Frat1重组蛋白
  • 货号：
    CSB-YP008970MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Frat1重组蛋白
  • 货号：
    CSB-EP008970MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Frat1重组蛋白
  • 货号：
    CSB-EP008970MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Frat1重组蛋白
  • 货号：
    CSB-BP008970MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Frat1重组蛋白
  • 货号：
    CSB-MP008970MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Frat1Proto-oncogene FRAT1; Frequently rearranged in advanced T-cell lymphomas 1; FRAT-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-274
  • 氨基酸序列
    MPCRREEEEE AGDEAEGEED DDSFLLLQQS VTLGGSTDVD QLIVQIGETL QLDAAHDRPA SPCAAPGPPP PQVLAALPAD KTGTPARRLL RPTGSAETGN PAPPGAVRCV LGERGRVRGR SAPYCVAEIS PGASALPQQP GLDGPPGTGK LSTPQPLSGP CRRGWLRNAA ASRRLQQRRG SQPETRTGDD DDPHRLLQQL VLSGNLIKEA VRRLHSRQLQ LHAKLPAHPF LGPLSAPVHE PPSPGSPRAA CSDPGAFMGR AQLRTGDDLL VPGS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.
  • 基因功能参考文献：
    1. Gsk3b is exported from the nucleus in a complex with Frat. Loss of PI3K/Akt activity results in dissociation of this complex and retention of Gsk3b in the nucleus. PMID: 22064483
    2. FRAT has a role in mediating GSK-3 nuclear export in mouse cells PMID: 12223487
    3. Data suggest that recruitment of Axin and Frat1 to the membrane by LRP5-triggered Wnt3 signaling leads to both Axin degradation and Frat1-mediated inhibition of glycogen synthase kinase-3. PMID: 15699046
  • 相关疾病：
    Activation contributes to progression of mouse T-cell lymphomas (PubMed:9034327).
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    GSK-3-binding protein family
  • 组织特异性：
    Highly expressed in testis. Lower level of expression in spleen, thymus and brain.
  • 数据库链接：

    KEGG: mmu:14296

    UniGene: Mm.4573