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  4. Recombinant Mouse Protein tyrosine phosphatase type IVA 3 (Ptp4a3)

Recombinant Mouse Protein tyrosine phosphatase type IVA 3 (Ptp4a3)

  • 中文名称：
    小鼠Ptp4a3重组蛋白
  • 货号：
    CSB-YP887531MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ptp4a3重组蛋白
  • 货号：
    CSB-EP887531MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ptp4a3重组蛋白
  • 货号：
    CSB-EP887531MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ptp4a3重组蛋白
  • 货号：
    CSB-BP887531MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ptp4a3重组蛋白
  • 货号：
    CSB-MP887531MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ptp4a3
  • Uniprot No.：
  • 别名：
    Ptp4a3; Prl3; Protein tyrosine phosphatase type IVA 3; EC 3.1.3.48; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PRL-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-170
  • 氨基酸序列
    MARMNRPAPV EVSYRHMRFL ITHNPSNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLLKA KFYNDPGSCV AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHTHKTRC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
  • 基因功能参考文献：
    1. our results suggest that the Prl3b1-cre mice line provides a unique resource to understand testicular germ-cell development PMID: 27124574
    2. Results demonstrate that Ptp4a3 contributes to the malignant phenotype of tumor-initiating cells. PMID: 24950307
    3. PRL-3 protein was significantly reduced in mouse STAT3-knockout liver cells compared with STAT3-wild type counterparts, and ectopic expression of STAT3 in these cells led to a pronounced increase in PRL-3 protein. PMID: 25139404
    4. Data indicate that Mycobacterium tuberculosis T cell stimulatory epitope (MT) is a potentially effective molecular adjuvant in preparation of monoclonal antibody (mAb) specific for phosphatase of regenerating liver-3 (PRL-3). PMID: 24909283
    5. These findings strongly support a role for PTP4A3 as an important contributor to endothelial cell function and as a multimodal target for cancer therapy and mitigating VEGF-regulated angiogenesis. PMID: 24403062
    6. the first definitive evidence implicating Ptp4a3 in colon tumorigenesis PMID: 23555575
    7. role of PTP4A3 in acute myeloid leukemia PMID: 22028901
    8. PTP4A3 was identified as a novel negative regulator of LPS-induced LITAF/TNF-alpha production. PMID: 20375622
    9. PRL-3 was highly expressed in metastatic melanoma B16-BL6 cells but not in its lowly metastatic parental cell line, B16 cells PMID: 15161639
    10. PRL-3-expressing cells rapidly induce metastatic tumor formation in lung PMID: 15326366
    11. expression is associated with gastric cancer metastases PMID: 16875667
    12. PRL-3 was shown to be expressed in the total mouse bone marrow fraction and more intensely in the Ter119-positive (pre-erythrocyte) fraction but not in the CD61-positive (megakaryocyte)fraction. PMID: 17018620
    13. Results suggest that Prl-3 plays a critical role in promoting the process of sponatneous metastasis and tumor growth initiation, and that inhibiting Prl-3 will improve melanoma therapy. PMID: 17592549
    14. Results identify Prl-3 (phosphatase of regenerating liver-3) as a p53-inducible gene, and demonstrate that Prl-3 is an important cell-cycle regulator. PMID: 18471976

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  • 亚细胞定位：
    Cell membrane. Early endosome.
  • 蛋白家族：
    Protein-tyrosine phosphatase family
  • 组织特异性：
    Present in the small intestine, where it is located in the differentiated epithelial cells of the villus but not in the proliferating crypt cells (at protein level). Expressed in heart and skeletal muscle, and at lower levels in lung, spleen and testis.
  • 数据库链接：

    KEGG: mmu:19245

    STRING: 10090.ENSMUSP00000060956

    UniGene: Mm.390807