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  4. Recombinant Mouse Protein spinster homolog 2 (Spns2), partial

Recombinant Mouse Protein spinster homolog 2 (Spns2), partial

  • 中文名称：
    小鼠Spns2重组蛋白
  • 货号：
    CSB-YP849648MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Spns2重组蛋白
  • 货号：
    CSB-EP849648MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Spns2重组蛋白
  • 货号：
    CSB-EP849648MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Spns2重组蛋白
  • 货号：
    CSB-BP849648MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Spns2重组蛋白
  • 货号：
    CSB-MP849648MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Spns2
  • Uniprot No.：
  • 别名：
    Spns2; Protein spinster homolog 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts a a crucial lysosphingolipid sphingosine 1-phosphate (S1P) transporter involved in S1P secretion and function. S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system. Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking.
  • 基因功能参考文献：
    1. genome-wide in vivo screen identifies novel host regulators of metastatic colonization, such as Spns2 PMID: 28052056
    2. results point to a broad role for Spns2-mediated S1P transport in the initiation and development of adaptive immune related disorders PMID: 26324848
    3. Spns2 expression by endothelial cells is essential for secretion of lymph S1P, while Spns2 is dispensable for RBC secretion of plasma S1P. PMID: 23103166
    4. Spns2 is an S1P transporter in vivo that plays a role in regulation not only of blood S1P but also lymph node and lymph S1P levels and consequently influences lymphocyte trafficking and lymphatic vessel network organization. PMID: 23180825
    5. SPNS2 is the first physiological S1P transporter in mammals and is a key determinant of lymphocyte egress from the thymus. PMID: 22723910
    6. The changes in lymphocyte subpopulations in mutant Spns2 mice closely mimick the phenotypes of partial sphingosine-1-phosphate (S1P) deficiency, impaired S1P-dependent lymphocyte trafficking, and depletion of circulating lymphocytes. PMID: 22664872
    7. Spns2 functions in endothelial cells to establish the S1P gradient required for T and B cells to egress from their respective primary lymphoid organs. PMID: 22406534
    8. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. PMID: 21084291

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Spinster (TC 2.A.1.49) family
  • 组织特异性：
    Expression is high in the lungs and liver, low in the lymph nodes, spleen and bone marrow, and very low but detectable in the thymus.
  • 数据库链接：

    KEGG: mmu:216892

    STRING: 10090.ENSMUSP00000044418

    UniGene: Mm.212812