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  4. Recombinant Mouse Protein odd-skipped-related 2 (Osr2)

Recombinant Mouse Protein odd-skipped-related 2 (Osr2)

  • 中文名称：
    小鼠Osr2重组蛋白
  • 货号：
    CSB-YP835604MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Osr2重组蛋白
  • 货号：
    CSB-EP835604MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Osr2重组蛋白
  • 货号：
    CSB-EP835604MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Osr2重组蛋白
  • 货号：
    CSB-BP835604MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Osr2重组蛋白
  • 货号：
    CSB-MP835604MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Osr2; Protein odd-skipped-related 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-312
  • 氨基酸序列
    MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PAAVDHLQGL YGLSAVQTMH MNHWTLGYPS VHEITRSTIT EMAAAQGLVD ARFPFPSLPF ATHLFHPKQG AIAHVLPALH KDRPRFDFAN LAVAATQEDP PKMGDLSKLS PGLGSPISGL SKLNPDRKPS RGRLPSKTKK EFICKFCGRH FTKSYNLLIH ERTHTDERPY TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS RTLAVHKTLH MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR RHSLTHTPRQ NF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Osr2 controls multiple molecular pathways, including BMP and Sema3 signaling, in palate development. PMID: 28731788
    2. these data reveal a novel mechanism that the Bmp4-Msx1 pathway and Osr2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt antagonists. PMID: 27713059
    3. Osr2 functions in reproductive system organs, such as the uterus, testes, prostate, placenta, and ovaries. PMID: 23872338
    4. Bmp4 signaling suppresses tooth developmental inhibitors in the tooth mesenchyme, including Dkk2 and Osr2, and synergizes with Msx1 to activate mesenchymal odontogenic potential for tooth morphogenesis and sequential tooth formation PMID: 23250216
    5. These results suggest that Osr2 is involved in TGF-beta regulating cell migration and cell cycle via a Smad3-ATF2 transcriptional complex mediating pathway. PMID: 22542937
    6. Mice lacking both Osr2 and Pax9 exhibited early tooth developmental arrest with significantly reduced Bmp4 and Msx1 mRNA expression in the developing tooth mesenchyme. PMID: 21420399
    7. These data indicate that Osr1 and Osr2 function redundantly to control synovial joint formation. PMID: 21262216
    8. Osr2 plays important roles in cell proliferation and development. PMID: 20599744
    9. Osr2 is a key intrinsic regulator of palatal growth and patterning PMID: 15175245
    10. Our results indicate that Osr2 bifurcates its function by alternative splicing. PMID: 15670784
    11. Osr2 expression is regulated by C/EBP regulatory elements PMID: 16436053
    12. genetic observations showed that the Osr2 gene plays a key role in osteoblastic cell proliferation PMID: 17547533
    13. An IresCre bicistronic expression cassette was inserted into the 3' UTR of the Osr2 gene through gene targeting. PMID: 17941042
    14. study found mice lacking Osr2 develop supernumerary teeth lingual to their molars because of expansion of the odontogenic field; Osr2 was expressed in a lingual-to-buccal gradient and restricted expression of bone morphogenetic protein 4 PMID: 19251632
    15. the distinct functions of Osr1 and Osr2 during mouse development result from evolutionary divergence of their cis regulatory sequences rather than distinct biochemical activities of their protein products. PMID: 19389375
    16. expressed during craniofacial, limb, and kidney development PMID: 11520675

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Odd C2H2-type zinc-finger protein family
  • 数据库链接：

    KEGG: mmu:107587

    STRING: 10090.ENSMUSP00000022952

    UniGene: Mm.46336