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  4. Recombinant Mouse Protein maelstrom homolog (Mael)

Recombinant Mouse Protein maelstrom homolog (Mael)

  • 货号：
    CSB-YP806916MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP806916MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP806916MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP806916MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP806916MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mael
  • Uniprot No.：
  • 别名：
    MaelProtein maelstrom homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-434
  • 氨基酸序列
    MPNRRASRNA YYFFVQEKIP ELRRRGLPVA RVADAIPYCS ADWALLREDE KEKYSEMARE WRAAQGKDSG PSEKQKLVST PLRRPGMLVP KPSISPPDMS NLSIKSDQAL LGGIFYFLNI FSHGELPPHC EQRFLPCEIG CVKYSLQEGI MADFHSFIHP GEIPRGFRFH CQAASDSSHK IPISNFEFGH DQATVLQNLY KFIHPNPGNW PPIYCKSDDR ARVNWCLKRM ERASEIRQDL ELLTVEDLVV GIYQQKFLKE PSKTWVRSLL DVAMWDYSSN TRCKWHEEND ILFCALAVCK KIAYCISNSL ATLFGIQLTG AHVPLQDYEA SNSVTPKMVV LDAGRYQKLR VESPGFCHFN SYNQEQRSNT STGYYPSGVK ISGPHSSVRG RGITRLLESI SNSSNNIHRF SSCETSLSPY TPQKDGYKPF SSFS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.
  • 基因功能参考文献：
    1. MAEL HMG-box domain may contribute to MAEL function in selective processing of retrotransposon RNA into piRNAs. PMID: 25807393
    2. an important role for Mael in early oogenesis and during germ-cell differentiation from embryonic stem cells PMID: 23410657
    3. s provide evidence of functional significance of these complexes in Mael129 knockout mice that exhibit spermiogenic arrest with acrosome and flagellum malformation. PMID: 25063675
    4. This study demonstrates that MAEL, a nuage component, is indispensable for the silencing of transposable elements (TEs) and identifies the initiation of meiosis as an important step in (TE) control in the male germline. PMID: 18694567
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Maelstrom family
  • 组织特异性：
    Testis-specific. Present in spermatocytes and round and early elongating spermatids.
  • 数据库链接：

    KEGG: mmu:98558

    STRING: 10090.ENSMUSP00000045828

    UniGene: Mm.26189