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  4. Recombinant Mouse Protein-lysine 6-oxidase (Lox)

Recombinant Mouse Protein-lysine 6-oxidase (Lox)

In Stock
  • 中文名称：
    小鼠Lox重组蛋白
  • 货号：
    CSB-BP013038MO
  • 规格：
    ￥1902
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Lox; Rrg; Protein-lysine 6-oxidase; EC 1.4.3.13; Lysyl oxidase; Ras excision protein) [Cleaved into: Protein-lysine 6-oxidase; long form; Protein-lysine 6-oxidase; short form]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    Baculovirus
  • 分子量：
    32.4
  • 表达区域：
    163-411aa
  • 氨基酸序列
    DDPYNPYKYSDDNPYYNYYDTYERPRPGSRNRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMSMYNLRCAAEENCLASSAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYAADIDCQWIDITDVQPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal 6xHis-Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer，50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture.
  • 基因功能参考文献：
    1. LOX over-expression in vascular smooth muscle cells was associated with a change in the structure of collagen and elastin fibres; LOX could constitute a novel source of oxidative stress that might participate in elastin changes and contribute to vascular remodelling PMID: 28624291
    2. LOX up-regulation is associated with enhanced oxidative stress that promotes p38MAPK activation, elastin structural alterations, and vascular stiffness. PMID: 28010122
    3. These results suggest that LOX has the ability to induce RANKL expression on stromal cells; however, it fails to substitute for RANKL in osteoclastogenesis. PMID: 27606829
    4. UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells. PMID: 28106301
    5. Data show that LOX-PP enhances adipogenesis at least partially through inhibition of FGF-2 receptor signaling. PMID: 28452589
    6. LOX targeting reduces peritoneal fibrosis. PMID: 28800626
    7. Absence of lysyl oxidase (Lox) causes thoracic aortic aneurysms. The aortic mechanical behavior of Lox(-/-) mice is consistent with reduced elastin and collagen cross-linking but demonstrates vascular location-specific differences. Lox(-/-) aortas show upregulation of matrix remodeling genes and location-specific differential expression of other matrix and smooth muscle cell gene sets. PMID: 28550176
    8. Findings from this study indicate that preventing LOX overexpression may be protective against high glucose-induced apoptosis in retinal vascular cells associated with diabetic retinopathy. PMID: 28538980
    9. LOX family members contribute significantly to the detrimental effects of cardiac remodelling, highlighting LOX inhibition as a potential therapeutic strategy for post-infarction recovery PMID: 26260798
    10. Findings suggest that the lysyl oxidase (LOX)-mediated organization of collagen fibers in the extracellular matrix is an important regulator of osteoblastogenesis. PMID: 26497171
    11. The data suggest a fibromodulin-modulated collagen cross-linking mechanism where fibromodulin binds to a specific part of the collagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cross-linking sites. PMID: 26893379
    12. Data suggest of pharmacologic targeting of lysyl oxidase (LOX) pathway to inhibit liver fibrosis and promote its resolution. PMID: 26700732
    13. Cu chaperone function of Atox1 mediated through Cu transporter ATP7A is required for VEGF-induced angiogenesis via activation of Cu enzyme lysyl oxidase. PMID: 26437801
    14. CTR1, ATP7A, and lysyl oxidase were upregulated in the lung tissues and pulmonary arteries of mice with hypoxia-induced pulmonary hypertension and pulmonary arterial smooth muscle cells. PMID: 24614111
    15. Inhibition of tissue transglutaminase resulted in a reduced rate of compaction compared to controls during early remodeling (up to 2 days). In contrast, inhibition of lysyl oxidase did not alter the early compaction. PMID: 25924936
    16. decreased expression of cross-linking enzymes (LOXs) and increased expression of ECM-degrading proteinases (MMP-1, 2, 3) might be of great contribution to poor healing ability of PCL ligament PMID: 25416119
    17. LOX is indispensable for the progression of BLM-induced experimental lung fibrosis by aggravating the inflammatory response and subsequent fibrosis process after lung injury. PMID: 25348956
    18. LOX and LOXL2 may play an important role in the pathogenesis of AMD. Targeting LOXL2 could have a broader efficacy than targeting LOX, by reducing angiogenesis and inflammation, as well as fibrosis. PMID: 26258612
    19. LOX plays a critical role in vascular remodelling PMID: 24990180
    20. LOX is a novel regulator of NFATc1-driven osteoclastogenesis, independent of RANK ligand, which disrupts normal bone homeostasis leading to the formation of focal pre-metastatic lesions PMID: 26017313
    21. DDR2 binding and activation were disrupted by collagen glycation, pointing to a mechanism for the diminished levels of lysyl oxidase and consequently low lysyl oxidase-derived cross-links in diabetic bone. PMID: 24120383
    22. miR-29b down-regulates HSP47 and LOX expression. PMID: 24650661
    23. lysyl oxidase activity participates in primary tumor growth by directly impacting the senescence stability. PMID: 24113189
    24. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-beta-deficient mouse mammary carcinomas. PMID: 23856251
    25. Silencing of lysyl oxidase in BMP4-treated C3H10T1/2 cells induced a mesenchymal-epithelial transition (MET)-like response associated with the repression of mesenchymal markers, induction of epithelial markers and decreased cell migration. PMID: 23395997
    26. LOX expression is strongly upregulated in Staphylococcus aureus infections in vivo. PMID: 23649089
    27. Suggest a causal relationship between LOX downregulation and aortic stiffening in obesity. PMID: 23413430
    28. Stress urinary incontinence following vaginal trauma involves over-expression of LOX and decreased synthesis of extracellular matrix components or increased proteolysis in the urethra. PMID: 22572217
    29. Data show that lysyl oxidase LOX staining intensity was intermittent in the ligamentum flavum over from stages E15 to 2 years, and stages that stained intensely were E16 and E18, and P7 through P21. PMID: 22685574
    30. the lysyl oxidase (Lox) protein is degraded through lysosome and accumulated in the Vps18 deficient cerebellum but not in cerebral cortices. PMID: 22699122
    31. Lysyl oxidase activity is essential to generate optimal chemotactic sensitivity of cells to chemoattractants by oxidizing specific cell surface proteins, such as platetlet-derived growth factor receptor (PDGFR)-beta. PMID: 21509606
    32. These results indicate that proLOX could be processed by two different mechanisms producing two forms of active LOX. PMID: 21591931
    33. LOX-PP is shown to negatively regulate pro-oncogenic beta-catenin signaling in lung cancer cells. PMID: 21690299
    34. LOX is a potential mediator that couples mechanotransduction to oncogenic signaling by TGF-beta1 and measures capable of inactivating LOX function may prove effective in diminishing breast cancer progression stimulated by TGF-beta1. PMID: 21532881
    35. in vitro and in vivo data support a novel role for LOX in regulating MK expansion by PDGF-BB and suggest LOX as a new potential therapeutic target for myelofibrosis PMID: 21665949
    36. Data show that CA9, GLUT1 and LOX mRNA levels were equally and strongly correlated to hypoxic extent in FaDudd, and the same profile was observed for CA9 and GLUT1, but not LOX, in SCCVII tumors. PMID: 21306648
    37. LKB1 loss of function promotes lung cancer malignancy through remodeling of extracellular matrix microenvironment, and identify LOX as a potential target for disease treatment in lung cancer patients. PMID: 20956321
    38. Suggest that uric acid increases fibronectin synthesis both in vivo and in vitro via urate transporters through upregulation of lysyl oxidase expression. PMID: 20484295
    39. periostin supported BMP-1-mediated proteolytic activation of LOX on the extracellular matrix, which promoted collagen cross-linking. PMID: 20181949
    40. LOX has a novel function in resolving inflammation by reducing MCP-1 in abdominal aortic aneurysm PMID: 19683237
    41. Lysyl oxidase has a role in oxidizing basic fibroblast growth factor and inactivating its mitogenic potential PMID: 12461785
    42. lysyl oxidase appears critical during embryogenesis for structural stability of the aorta and diaphragm and connective tissue development PMID: 12473682
    43. Lox expression is prominent during embryonic cardiovascular development. PMID: 12524683
    44. Anti-oncogenic effects of lysyl oxidase on ras-mediated transformation are due to its ability to inhibit signaling pathways that lead to activation of NF-kappa B PMID: 12640111
    45. FGF-2 autocrine pathway inhibits lysyl oxidase transcription in the tumorigenic-transformed RS485 cell line. PMID: 12788924
    46. The LOX expressed in the choroid plexus, blood vessel walls, brain matrix, and neurons of normal mice. And LOX gene expression was enhanced in the neurons of the spinal cord, brain stem, cortex, caudoputamen and cerebellum in mSOD1 mice. PMID: 14741400
    47. collagen deposition and lysyl oxidase are regulated by tumor necrosis factor-alpha in osteoblasts PMID: 15138266
    48. lysyl oxidase functions to inhibit ras-dependent cell transformation PMID: 15277520
    49. Results compare the immunohistochemical localization of lysyl oxidase and lysyl oxidase-like in various tissues from normal, young adult mice. PMID: 15609098
    50. the FN matrix may provide specific microenvironments to regulate LOX catalytic activity PMID: 15843371

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  • 亚细胞定位：
    Secreted. Secreted, extracellular space.
  • 蛋白家族：
    Lysyl oxidase family
  • 组织特异性：
    Expressed in aorta (at protein level). Expressed in embryonic, juvenil and adult aorta.
  • 数据库链接：

    KEGG: mmu:16948

    STRING: 10090.ENSMUSP00000025409

    UniGene: Mm.172