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  4. Recombinant Mouse Protein BANP (Banp)

Recombinant Mouse Protein BANP (Banp)

  • 货号：
    CSB-YP823724MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP823724MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP823724MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP823724MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP823724MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Banp
  • Uniprot No.：
  • 别名：
    Banp; Smar1Protein BANP; Btg3-associated nuclear protein; Scaffold/matrix-associated region-1-binding protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-548
  • 氨基酸序列
    MMSEQDLADV VQIAVEDLSP DHPVVLENHV VTDDDEPALK RQRLEINCQD PSIKSFLYSI NQTICLRLDS IEAKLQALEA TCKSLEEKLD LVTNKQHSPI QVPMVAGSPL GATQTCNKVR CVVPQTTVIL NNDRQNAIVA KMEDPLSNRA PDSLENIISN AVPGRRQNTI VVKVPGQDDS HNEDGESGSE ASDSVSNCGQ PGSQNIGSNV TLITLNSEED YPNGTWLGDE NNPEMRVRCA IIPSDMLHIS TNCRTAEKMA LTLLDYLFHR EVQAVSNLSG QGKHGKKQLD PLTIYGIRCH LFYKFGITES DWYRIKQSID SKCRTAWRRK QRGQSLAVKS FSRRTPSSSS YSASETMMGT PPPTSELQQS QPQALHYALA NAQQVQIHQI GEDGQVQVIP QGHLHIAQVP QGEQVQITQD SEGNLQIHHV GQDGQSWGLC QNPIPVSGDS VAQANPSQLW PLGGDTLDLP AGNEMIQVLQ GAQLIAVASS DPAATGVDGS PLQGSDIQVQ YVQLAPVSDH TAAAQTAEAL QPTLQPDMQL EHGAIQIQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest and inhibits tumor growth.
  • 基因功能参考文献：
    1. SMAR1 downregulation enhances the tumor killing effect of CD8+T cells by activating T-bet and down-regulating PD-1. PMID: 30301506
    2. SMAR1 transgenic mice exhibited susceptibility to M. tuberculosis infection in vivo irrespective of genetic background. This susceptibility was attributed to downregulation of Th1 response and its hallmark cytokine IFN-gamma PMID: 26831422
    3. This study reveals a critical role of SMAR1 in maintaining the proinflammatory immune responses by repressing Th1 and Th17 cell function and it gives the novel insight into immune regulatory mechanisms. PMID: 26609032
    4. we report an essential role of the matrix attachment region (MAR)-binding protein SMAR1 in regulating immune response during allergic airway disease PMID: 25736456
    5. SMAR1, a known transcription factor and tumor suppressor, is directly involved in maintaining regulatory T cell fate decision PMID: 25993445
    6. Glucose deprivation can induce p53 internal ribosome entry sites (IRESs) and also increases cytoplasmic abundance of SMAR1 that in turn binds to p53 IRESs, indicating the role of SMAR1 in controlling translation of p53 isoforms. PMID: 25721046
    7. combined action of Foxp3 and SMAR1 restricts effector cytokine production and enhance the production of IL-10 by colonic Treg cells that controls acute colitis PMID: 26168735
    8. A novel mechanism of regulation of oxidative stress by ATM through modulation of SMAR1-AKR1a4 complex, is proposed. PMID: 20097305
    9. C/EBPbeta may regulate preadipocyte proliferation through activation of banp and trim35. PMID: 20529561
    10. SMAR1 modulates the roughness of cell surface. PMID: 19799771
    11. SMAR1-mediated stabilization of p53 is brought about by inhibiting Mdm2-mediated degradation of p53 PMID: 15701641
    12. A short SMAR1 peptide efficiently activates p53 protein by mediating its phosphorylation at serine 15, resulting in the activation of p21 and in effect regulating cell cycle checkpoint. PMID: 17229733

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BANP/SMAR1 family
  • 组织特异性：
    Highly expressed in heart, spleen, and thymus. Isoform 1 is highly expressed in kidney, brain and testis. Isoform 3 is highly expressed in kidney and lung.
  • 数据库链接：

    KEGG: mmu:53325

    STRING: 10090.ENSMUSP00000132095

    UniGene: Mm.287163