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  4. Recombinant Mouse Proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2)

Recombinant Mouse Proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2)

  • 中文名称：
    小鼠Pstpip2重组蛋白
  • 货号：
    CSB-YP859980MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pstpip2重组蛋白
  • 货号：
    CSB-EP859980MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pstpip2重组蛋白
  • 货号：
    CSB-EP859980MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pstpip2重组蛋白
  • 货号：
    CSB-BP859980MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pstpip2重组蛋白
  • 货号：
    CSB-MP859980MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pstpip2
  • Uniprot No.：
  • 别名：
    Pstpip2; Mayp; Proline-serine-threonine phosphatase-interacting protein 2; PEST phosphatase-interacting protein 2; Macrophage actin-associated tyrosine-phosphorylated protein; pp37
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-334
  • 氨基酸序列
    TGSLFKGNF WSTDILSTIG YDSIIQHLNN GRKNCKEFED FLKERASIEE KYGKDLLNLS RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQTLRE EARKMEEFRE KQKLQRKKTE TIMDAAHKQR NAQFKKAMDA KKNYEQKCRD KDEAEQAVHR SANVANQRQQ EKLFVKLATS KTAVEDSDKA YMLHINMLEK VREDWQSEHI KACEVFEAQE CERINFFRNA LWLHLNQLSQ QCVANDEMYE QVRKSLETCS IEKDIQYFVN QRKTGQTPPA PIMYENFYSP QRNAAPPGKT TGPNPARRGP LPVPKRIPDD PDYSVVEDYS LLYQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to F-actin. May be involved in regulation of the actin cytoskeleton.
  • 基因功能参考文献：
    1. PSTPIP2 could play a role in innate immunity and development of autoinflammatory bone disorders, and may be associated with the pathogenesis of SAPHO syndrome. PMID: 25602062
    2. Knockdown of PSTPIP2 inmacrophages enhances the assembly of FBP17, leading to'hyperactivation' of actin nucleation at podosomes and ECM degradation. PMID: 23525018
    3. PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts. PMID: 22923495
    4. our pstpip2 mutant mice provide a new model for investigating the potential mechanisms of inflammatory pain. PMID: 22646813
    5. MAYP directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages. PMID: 15788569
    6. A missense mutation in pstpip2 is associated with the autoinflammatory disorder chronic multifocal osteomyelitis. PMID: 16122996
    7. mutations are associated with spontaneous disease in mouse model of osteomyelitis PMID: 18721907
    8. PSTPIP2 deficiency leads to autoinflammatory disease. PMID: 19608749

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 组织特异性：
    Expressed in macrophage-containing tissues, including bone marrow, spleen, liver, kidney, intestine and brain.
  • 数据库链接：

    KEGG: mmu:19201

    STRING: 10090.ENSMUSP00000110389

    UniGene: Mm.57174