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  4. Recombinant Mouse Pro-cathepsin H (Ctsh)

Recombinant Mouse Pro-cathepsin H (Ctsh)

  • 中文名称：
    Recombinant Mouse Pro-cathepsin H(Ctsh),Yeast
  • 货号：
    CSB-YP006191MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Pro-cathepsin H(Ctsh),Yeast
  • 货号：
    CSB-EP006191MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Pro-cathepsin H(Ctsh),Yeast
  • 货号：
    CSB-EP006191MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Pro-cathepsin H(Ctsh),Yeast
  • 货号：
    CSB-BP006191MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Pro-cathepsin H(Ctsh),Yeast
  • 货号：
    CSB-MP006191MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ctsh; Pro-cathepsin H; Cathepsin B3; Cathepsin BA) [Cleaved into: Cathepsin H mini chain; Cathepsin H; EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    96-103
  • 氨基酸序列
    EPQNC SAT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Important for the overall degradation of proteins in lysosomes.
  • 基因功能参考文献：
    1. CatH deficiency impaired toll-like receptor 3-mediated activation of interferon regulatory factor 3 and consequent secretion of IFN-beta PMID: 29470604
    2. The data provide strong evidence that CTSH is an important regulator of beta-cell function during progression of T1D PMID: 24982147
    3. Cathepsin H knockout mice show reduced brain levels of (Met)enkephalin and galanin. PMID: 22582844
    4. cathepsin H is involved in the SP-B production. PMID: 22022579
    5. CTSH overexpression in a subset hepatoma may be thyroid hormone receptor dependent and suggests that this overexpression has an important role in hepatoma progression. PMID: 21217776
    6. In two mouse models of pancreatic islet cancer, deletion of CtsH reduced tumor progression; mechanisms involved impaired angiogenic switching from premalignant state, poor vascularization of tumors, and increased apoptosis. PMID: 20731543
    7. In proteolipid protein transgenic mice cathepsin H is upregulated primarily in microglia/macrophages of white matter. PMID: 17086443
    8. Presence of cathepsin H and (bone morphogenetic protein 4)BMP4 in lung or other developing organs suggest that cathepsin H regulates BMP4 proteolysis in morphogenesis. PMID: 17500053

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  • 亚细胞定位：
    Lysosome.
  • 蛋白家族：
    Peptidase C1 family
  • 组织特异性：
    Widely expressed with highest expression found in non-skeletal tissues. Low levels found in skeletal tissue.
  • 数据库链接：

    KEGG: mmu:13036

    STRING: 10090.ENSMUSP00000034915

    UniGene: Mm.2277