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  4. Recombinant Mouse Pro-FMRFamide-related neuropeptide VF (Npvf), partial

Recombinant Mouse Pro-FMRFamide-related neuropeptide VF (Npvf), partial

  • 中文名称：
    小鼠Npvf重组蛋白
  • 货号：
    CSB-YP884159MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Npvf重组蛋白
  • 货号：
    CSB-EP884159MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Npvf重组蛋白
  • 货号：
    CSB-EP884159MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Npvf重组蛋白
  • 货号：
    CSB-BP884159MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Npvf重组蛋白
  • 货号：
    CSB-MP884159MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Npvf
  • Uniprot No.：
  • 别名：
    Npvf; Rfrp; Pro-FMRFamide-related neuropeptide VF; FMRFamide-related peptides) [Cleaved into: Neuropeptide NPSF; Neuropeptide RFRP-1; Neuropeptide NPVF; Neuropeptide RFRP-2)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    partial
  • 表达区域：
    58-94
  • 氨基酸序列
    SVS FQELKDWGAK NVIKMSPAPA NKVPHSAANL PLRF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP. Neuropeptide NPVF blocks morphine-induced analgesia.
  • 基因功能参考文献：
    1. Hypothyroidism showed delayed pubertal onset with increased GnIH expression and reduced pituitary-gonadal activity. PMID: 28432332
    2. findings suggest that the suppressive signalling of RFRP-3 on Gonadotrophin releasing hormone transcription may dominate over kisspeptin induction in the mHypoA-GnRH/GFP Gonadotrophin releasing hormone neuronal cell model. PMID: 25283492
    3. RF-amide-related peptide-3 (RFRP-3), the mammalian ortholog of the avian gonadotropin-inhibiting hormone (GnIH), operates via the NPFF1 receptor (NPFF1R) to repress the reproductive axis. PMID: 24823392
    4. RFRP-3 may exert its effects on reproduction either directly, via Gpr147 in a subset of GnRH neurons, and/or indirectly, via upstream regulators of GnRH. PMID: 22355072
    5. Interaction between GnRH I-RFRP-3 neuropeptides may be involved in the regulation of follicular development and atresia. PMID: 21769536
    6. It is concluded that aging mice exhibits inverse correlation of RFRP-3 neurons and gonadal activity suggesting that function of RFRP-3 is not initiated until 1-week of age and thereafter it could participate in the regulation of gonadal development. PMID: 20433842
    7. RFRP-3 has a likely direct suppressive action on the excitability of GnRH neurons, indicating a role for RFRPs in the regulation of gonadotropin secretion in mammals through modulation of GnRH neuron activity. PMID: 19131572

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    FARP (FMRFamide related peptide) family
  • 数据库链接：

    KEGG: mmu:60531

    STRING: 10090.ENSMUSP00000031853

    UniGene: Mm.157158