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  4. Recombinant Mouse Polymerase delta-interacting protein 2 (Poldip2)

Recombinant Mouse Polymerase delta-interacting protein 2 (Poldip2)

  • 中文名称：
    小鼠Poldip2重组蛋白
  • 货号：
    CSB-YP838671MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Poldip2重组蛋白
  • 货号：
    CSB-EP838671MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Poldip2重组蛋白
  • 货号：
    CSB-EP838671MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Poldip2重组蛋白
  • 货号：
    CSB-BP838671MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Poldip2重组蛋白
  • 货号：
    CSB-MP838671MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Poldip2
  • Uniprot No.：
  • 别名：
    Poldip2; Polymerase delta-interacting protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-368
  • 氨基酸序列
    MAGCVARRAL AVGSRWWSRS LATTRGSRPL CAVGGAGGLP PVATATTRRH LSSRNRAEGK VLETVGVFEV PKQNGKYETG QLFLHSVFGY RGVVLFPWQA RLYDRDVASA TPEKAENPAG HGSKEVKGKT HTYYQVLIDA RDCPHISQRS QTEAVTFLAN HDDSRALYAI PGLDYVSHED ILPYTSTDQV PIQHELFERF LLYDQTKAPP FVARETLRAW QEKNHPWLEL SDVHRETTEN IRVTVIPFYM GMREAQNSHV YWWRYCIRLE NLDSDVVQLR ERHWRIFSLS GTLETVRGRG VVGREPVLSK EQPAFQYSSH VSLQASSGHM WGTFRFERPD GSHFDVRIPP FSLESNKDEK TPPSGLHW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites. May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1).
  • 基因功能参考文献：
    1. Poldip2 expression is down-regulated by hypoxia in a variety of cell types and basally repressed in triple-negative cancer cells, leading to inhibition of lipoylation of the pyruvate and alpha-KDH complexes and mitochondrial dysfunction. PMID: 29434038
    2. the rate of collagen I degradation was increased in Poldip2(+/-) vs. Poldip2(+/+) MASMs. Conversely, activation of the PI3K/Akt/mTOR signaling pathway, involved in regulation of protein synthesis, was significantly elevated in Poldip2(+/-) MASMs as was beta1-integrin expression. PMID: 26801741
    3. Poldip2 is an essential protein in development, and underline its importance in cell viability and proliferation PMID: 24797518
    4. Suggest Poldip2 promotes ischemia-induced collateral vessel formation via multiple mechanisms that likely involve reactive oxygen species-dependent activation of matrix metalloproteinase activity, as well as enhanced vascular cell growth and survival. PMID: 24855063
    5. Poldip2 expression is necessary for maintainance vascular integrity and function. PMID: 23825363
    6. miR-291a-5p directly inhibited the expression of PDIP38. PMID: 21090114
    7. plays a role in the regulation of mitochondrial morphology. (review) PMID: 21048415
    8. overexpression of Mitogenin I or mitochondrial single-stranded DNA-binding protein increased elongated or fragmented mitochondria in mouse C2C12 myoblast cells, respectively. PMID: 16860483

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  • 亚细胞定位：
    Mitochondrion matrix. Nucleus.
  • 数据库链接：

    KEGG: mmu:67811

    STRING: 10090.ENSMUSP00000001127

    UniGene: Mm.197493