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  4. Recombinant Mouse Plasmalemma vesicle-associated protein (Plvap), partial

Recombinant Mouse Plasmalemma vesicle-associated protein (Plvap), partial

  • 中文名称：
    小鼠Plvap重组蛋白
  • 货号：
    CSB-YP845975MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Plvap重组蛋白
  • 货号：
    CSB-EP845975MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Plvap重组蛋白
  • 货号：
    CSB-EP845975MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Plvap重组蛋白
  • 货号：
    CSB-BP845975MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Plvap重组蛋白
  • 货号：
    CSB-MP845975MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Plvap
  • Uniprot No.：
  • 别名：
    Plvap; Pv1; Plasmalemma vesicle-associated protein; MECA-32 antigen; Plasmalemma vesicle protein 1; PV-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.
  • 基因功能参考文献：
    1. These results show that Plvap expression in endothelial cells is important in the maintenance of IgM(+) B cells in the spleen and peritoneal cavity. PMID: 27742829
    2. an endothelium-specific molecule, plasmalemma vesicle-associated protein (PLVAP), regulates the seeding of fetal monocyte-derived macrophages to tissues in mice PMID: 27732581
    3. Results indicate that PLVAP is not only required for the formation of endothelial diaphragms, but also for the formation of endothelial fenestrae, even of those without diaphragms. PMID: 25541982
    4. In the lymphatic sinus, PLVAP forms a physical sieve that regulates the parenchymal entry of lymphocytes and soluble antigens. PMID: 25665101
    5. PV1 is involved in the tumor angiogenesis PMID: 22568538
    6. formation of diaphragms is the only role of PV1 PMID: 22403691
    7. upregulation of microvascular expression of PV-1 post-spinal cord injury may promote major components of secondary injury PMID: 20590523
    8. The PV-1 protein is negatively regulated in pulmonary endothelial cells by VEGF-R2 signaling. PMID: 16969073
    9. Compelling evidence for a functional role of PV-1 in the formation of large transendothelial channels and modulation of nuclear shape. PMID: 16969078
    10. PV-1 is necessary for fenestral pore architecture and the ordered arrangement of fenestrae in sieve plates. PMID: 17075074

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein. Membrane, caveola; Single-pass type II membrane protein. Cytoplasm, perinuclear region.
  • 组织特异性：
    Expressed in lung, kidney, spleen, heart, muscle, eye, pancreas, thyroid, thymus, submaxillary gland, prostate, epididymis, uterus and liver.
  • 数据库链接：

    KEGG: mmu:84094

    STRING: 10090.ENSMUSP00000035404

    UniGene: Mm.260768