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  4. Recombinant Mouse Plakophilin-1 (Pkp1)

Recombinant Mouse Plakophilin-1 (Pkp1)

  • 中文名称：
    小鼠Pkp1重组蛋白
  • 货号：
    CSB-YP018079MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pkp1重组蛋白
  • 货号：
    CSB-EP018079MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pkp1重组蛋白
  • 货号：
    CSB-EP018079MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pkp1重组蛋白
  • 货号：
    CSB-BP018079MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pkp1重组蛋白
  • 货号：
    CSB-MP018079MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pkp1
  • Uniprot No.：
  • 别名：
    Pkp1; Plakophilin-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-728
  • 氨基酸序列
    MNHSPLKTAL AYECFQDQDN STLALPSDQK MKTGTSGRQR VQEQVMMTVK RQKSKSSQSS TLSHSNRGSM YDGLADNYNN YGTTSRSSYF SKFQAGNGSW GYPIYNGTLK REPDNRRFSS YSQMENWSRH YPRGSCATPG AGSDICFMQK IKASRSEPDL YCDPRGTLRK GTLGSKGHKT TQNRCSFYST CSGQKAVKKC PVRPPSCTSK QDPVYVPPIS CNKDLSFGHS RASSKICSED IECSGLTIPK AVQYLCSQDE KYQAIGAYYI QHTCFQDESA KQQVYQLGGI CKLVDLLRSP NQNVQQAAAG ALRNLVFRST PNKLETRRQN GIREAVSLLR RSGSTEIQKQ LTGLLWNLSS TDELKEELVA DALPVLTDRV IIPFSGWCDG NSNMSREVVD PEVFFNATGC LRNLSSADAG RQTMRNYSGL IDSLMAYVQN CVAASRCDDK SVENCMCILH NLSYRLDAEV PTRYRQLEYN TRNAYTEKSS TGCFSNRGDK MMNNNYDCPL PEEETNPKGS SWLYHSDAIR TYLNLMGKSK KDATLEACAG ALQNLTASKG LMSNGMSQLI GIKEKGLPQI ARLLQSGNSD VVRSGASLLS NMSRHPVLHR VMGNQVFPEV TRLLTSHTGN TSNSEDILSS ACYTVRNLMT SQPQMAKQYF SNSMLNNVFN LCRNTASSPK AAEAARLLLS DMWASKELQS VLRQQGFDRN MMGNIAGANN LRNFTSRF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Seems to play a role in junctional plaques.
  • 基因功能参考文献：
    1. PKP1 has roles in desmosome and tight junction function and in growth control, a function that is crucial in wound healing and epidermal carcinogenesis PMID: 27033150
    2. This approach identified a key signaling event, phosphorylation of a desmosome component, PKP1 (plakophilin-1) by RIPK4 (receptor-interacting serine-threonine kinase 4) during epidermal differentiation. PMID: 28507225
  • 亚细胞定位：
    Nucleus. Cell junction, desmosome.
  • 蛋白家族：
    Beta-catenin family
  • 数据库链接：

    KEGG: mmu:18772

    STRING: 10090.ENSMUSP00000027667

    UniGene: Mm.4494