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  4. Recombinant Mouse Phosphatidylethanolamine-binding protein 1 (Pebp1)

Recombinant Mouse Phosphatidylethanolamine-binding protein 1 (Pebp1)

  • 中文名称：
    小鼠Pebp1重组蛋白
  • 货号：
    CSB-YP017766MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pebp1重组蛋白
  • 货号：
    CSB-EP017766MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pebp1重组蛋白
  • 货号：
    CSB-EP017766MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pebp1重组蛋白
  • 货号：
    CSB-BP017766MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pebp1重组蛋白
  • 货号：
    CSB-MP017766MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pebp1
  • Uniprot No.：
  • 别名：
    Pebp1; Pbp; PebpPhosphatidylethanolamine-binding protein 1; PEBP-1; HCNPpp) [Cleaved into: Hippocampal cholinergic neurostimulating peptide; HCNP)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-187
  • 氨基酸序列
    AADISQWAG PLCLQEVDEP PQHALRVDYA GVTVDELGKV LTPTQVMNRP SSISWDGLDP GKLYTLVLTD PDAPSRKDPK FREWHHFLVV NMKGNDISSG TVLSDYVGSG PPSGTGLHRY VWLVYEQEQP LSCDEPILSN KSGDNRGKFK VETFRKKYNL GAPVAGTCYQ AEWDDYVPKL YEQLSGK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.; HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.
  • 基因功能参考文献：
    1. Low RKIP Expression is associated with asthma. PMID: 30282734
    2. Results suggested that RKIP may inhibit the TNF-alpha-induced expression of adhesion molecules in MOVACs through inactivation of the NF-kappaB pathway. PMID: 28983072
    3. findings report that RKIP preferentially regulates the TLR3-mediated immune response in macrophages; phosphorylation of RKIP serine 109 is required for RKIP to promote TLR3-mediated signaling and inflammation PMID: 28411188
    4. The s report that Raf kinase inhibitory protein (RKIP) is essential for TBK1 activation and type I interferon production triggered by viral infection. PMID: 27753621
    5. RKIP contributes to colitis development by promoting inflammation and mediating intestinal epithelial cell apoptosis. PMID: 26801887
    6. RKIP knockdown promotes ERK1 and PPAR gamma activation during adipogenesis. PMID: 27470585
    7. this study shows that didymin ameliorates hepatic injury through up-regulating RKIP expression PMID: 27912149
    8. overexpression of RKIP attenuated microglia inflammation through inhibiting the NF-kappaB signaling pathway in erythrocyte lysis-treated BV2 cells. PMID: 27262809
    9. Overexpression of RKIP inhibits retinal ganglion cells apoptosis and promotes axonal regeneration after optic nerve crush. PMID: 26160696
    10. RKIP overexpression increases cardiac contractility mediated by the beta1-adrenoceptor. RKIP deficiency exaggerates pressure overload-induced cardiac failure. RKIP is upregulated in heart failure. PMID: 26479924
    11. In syngeneic mammary tumors, RKIP regulates tumor-associated macrophage recruitment by blocking HMGA2, resulting in reduced expression of numerous macrophage chemotactic factors, including CCL5.. PMID: 26238785
    12. These findings suggest that in addition to its known metastasis suppressor activity, RKIP may promote tumor progression through enhancing tumor initiation. PMID: 25327941
    13. Epigenetic Pebp1 inactivation may affect activation of ERK, and it could impair spermatogenesis of mice. PMID: 24198121
    14. The concomitant depletion of RKIP can rescue the compromised ERK activation and cell proliferation through a Raf-1-dependent mechanism. PMID: 23416466
    15. RKIP is necessary for the exaggerated production of IFN-gamma from Systemic inflammatory response syndrome splenocytes. PMID: 23761631
    16. Protein kinase C-dependent regulation of raf kinase inhibitory protein leads to MAP kinase activation that is required for long-term synaptic depression. PMID: 23055494
    17. Raf-1 kinase inhibitory protein (RKIP) mediates ethanol-induced sensitization of secretagogue signaling in pancreatic acinar cells PMID: 22859298
    18. Rkip prevents cilia formation and is associated with Cep290-mediated photoreceptor degeneration. PMID: 21685394
    19. Ciliary movement may help control the expression of the Raf-1 kinase inhibitor protein and thus maintain cell differentiation. PMID: 21345975
    20. The results indicate that Sch B triggers the Raf/MEK/ERK signaling pathway, presumably by downregulating RKIP. PMID: 21155602
    21. Raf kinase inhibitory protein 1 (RKIP-1) function may influence metastasis, angiogenesis, apoptosis, and genome integrity. Attenuation of RKIP-1 may affect cardiac functions, spermatogenesis, and reproduction [RKIP-1, review]. PMID: 17706925
    22. studies indicate an important role for RKIP in reproduction as a modulator of capacitation but not in the regulation of testicular injury. PMID: 17554109
    23. The results of this study suggested that either HCNP and/or HCNP precursor protein may evoke the depressive-like phenotype via cholinergic hyperactivity from early neonatal life and/or inhibition of phosphorylated Erk in the neonatal hippocampus. PMID: 20599825
    24. PEBP inhibits cell proliferation and induces differentiation of human keratinocytes PMID: 15155742
    25. In this study, the accumulation of HCNP and/or HCNP precursor in hippocampus was found to progress from 2 to 5 months of age in senescence-accelerated mouse-prone 8 (SAM P8). PMID: 17570350
    26. Results suggest that RKIP and annexin A5 are related to the ascorbic acid-mediated suppression of tumor formation. PMID: 19224539
    27. RKIP has a role in potentially sequestering toxic compounds, including locostatin, that may have deleterious effects on cells PMID: 19551145
    28. This result suggests that HCNP is involved in regulating acetylcholine synthesis in vivo in the medial septal nucleus and, as such, is important for memory function. PMID: 19815004

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Phosphatidylethanolamine-binding protein family
  • 组织特异性：
    HCNP is expressed in brain. Increased expression in aged senescence-accelerated mice.
  • 数据库链接：

    KEGG: mmu:23980

    STRING: 10090.ENSMUSP00000048425

    UniGene: Mm.195898