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  4. Recombinant Mouse Pescadillo homolog (Pes1)

Recombinant Mouse Pescadillo homolog (Pes1)

  • 中文名称：
    小鼠Pes1重组蛋白
  • 货号：
    CSB-YP875338MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pes1重组蛋白
  • 货号：
    CSB-EP875338MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pes1重组蛋白
  • 货号：
    CSB-EP875338MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pes1重组蛋白
  • 货号：
    CSB-BP875338MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pes1重组蛋白
  • 货号：
    CSB-MP875338MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pes1
  • Uniprot No.：
  • 别名：
    Pes1; Pes; Pescadillo homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-584
  • 氨基酸序列
    MGGLEKKKYE RGSATNYITR NKARKKLQLS LPDFRRLCIL KGIYPHEPKH KKKVNKGSTA ARTFYLIKDI KFLLHEPIVN KFREYKVFVR KLRKAYGKSE WNAVERLKDN KPCYKLDHIV KERYPTFIDA LRDLDDALSM CFLFSTFPRT GKCHVQTIQL CRRLTVEFLH YVITARALRK VFLSIKGIYY QAEVLGQPIV WIAPYAFSHD HPTDVDYRVM ATFTEFYTTL LGFVNFRLYQ SLNLHYPPKL EGQAQAETKI SEDTYALDSE SSMEKLAALS ASLARVVVPA IEEAEADEFP TDGEVTAQEE DRKKELEAQE KHKKLFEGLK FFLNREVPRE ALAFIIRSFG GDVSWDKSLC IGATYDVTDS CITHQIVDRP GQQTPIIGRY YVQPQWVFDC VNARLLLPVA EYFPGMQLPP HLSPFVSEKE GDYIPPEKLK LLALQRGEDP GHLEEEEEED EDDDNEGDVA AENEEEDVEV ESEEEEEEEV HLSALEQHRL EEKKPQVMAG TVKLEDKQRL AQEEESEAKR LAIMMMKKRE KYLYQKIMFG KRRKIREANK LAEKRKAHDD AVRSEKKAKR TRPV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
  • 基因功能参考文献：
    1. These data suggest that PES1 is a marker of neuroblastoma outcome, that it regulates neuroblastoma cell proliferation, and is associated with neuroblastoma differentiation. PMID: 25557119
    2. Data show that pescadillo associates with several structures that are associated with nucleogenesis, and that loss of function results in embryonic lethality due to disrupted ribosome biosynthesis. PMID: 12237316
    3. Interaction with Bop1 is essential for the efficient incorporation of Pes1 into nucleolar preribosomal complexes. PMID: 15225545
    4. Mechanisms for the ability of Pes1 to transform cells, and its failure to immortalize them. PMID: 15273728
    5. Mtap1b-Light chain 1 has the potential to repress cell proliferation by modulating the nucleolar levels of Pes1 PMID: 17308336

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  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli.
  • 蛋白家族：
    Pescadillo family
  • 组织特异性：
    Ubiquitous. Highest levels appear to be found in tissues that contain a population of proliferating cells, such as ovary and testis. Also appears to be highly expressed in kidney and liver. In the brain expression is restricted to neural progenitor cells
  • 数据库链接：

    KEGG: mmu:64934

    STRING: 10090.ENSMUSP00000020705

    UniGene: Mm.28659