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  4. Recombinant Mouse Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (Ppargc1a)

Recombinant Mouse Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (Ppargc1a)

  • 中文名称：
    小鼠Ppargc1a重组蛋白
  • 货号：
    CSB-YP529139MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ppargc1a重组蛋白
  • 货号：
    CSB-EP529139MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ppargc1a重组蛋白
  • 货号：
    CSB-EP529139MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ppargc1a重组蛋白
  • 货号：
    CSB-BP529139MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ppargc1a重组蛋白
  • 货号：
    CSB-MP529139MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ppargc1a; Pgc1; Pgc1a; Ppargc1; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-797
  • 氨基酸序列
    MAWDMCSQDS VWSDIECAAL VGEDQPLCPD LPELDLSELD VNDLDTDSFL GGLKWCSDQS EIISNQYNNE PANIFEKIDE ENEANLLAVL TETLDSLPVD EDGLPSFDAL TDGAVTTDNE ASPSSMPDGT PPPQEAEEPS LLKKLLLAPA NTQLSYNECS GLSTQNHAAN HTHRIRTNPA IVKTENSWSN KAKSICQQQK PQRRPCSELL KYLTTNDDPP HTKPTENRNS SRDKCASKKK SHTQPQSQHA QAKPTTLSLP LTPESPNDPK GSPFENKTIE RTLSVELSGT AGLTPPTTPP HKANQDNPFK ASPKLKPSCK TVVPPPTKRA RYSECSGTQG SHSTKKGPEQ SELYAQLSKS SGLSRGHEER KTKRPSLRLF GDHDYCQSLN SKTDILINIS QELQDSRQLD FKDASCDWQG HICSSTDSGQ CYLRETLEAS KQVSPCSTRK QLQDQEIRAE LNKHFGHPCQ AVFDDKSDKT SELRDGDFSN EQFSKLPVFI NSGLAMDGLF DDSEDESDKL SYPWDGTQPY SLFDVSPSCS SFNSPCRDSV SPPKSLFSQR PQRMRSRSRS FSRHRSCSRS PYSRSRSRSP GSRSSSRSCY YYESSHYRHR THRNSPLYVR SRSRSPYSRR PRYDSYEAYE HERLKRDEYR KEHEKRESER AKQRERQKQK AIEERRVIYV GKIRPDTTRT ELRDRFEVFG EIEECTVNLR DDGDSYGFIT YRYTCDAFAA LENGYTLRRS NETDFELYFC GRKQFFKSNY ADLDTNSDDF DPASTKSKYD SLDFDSLLKE AQRSLRR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. Isoform 4 specifically activates the expression of IGF1 and suppresses myostatin expression in skeletal muscle leading to muscle fiber hypertrophy.
  • 基因功能参考文献：
    1. The expression level of myocardial PGC-1alpha in MI mice with cardiac rupture after MI was significantly higher than that in the mice without cardiac rupture, and the ratio of myocardial NT-PGC-1alpha/PGC-1alpha was low. PMID: 30275441
    2. These findings show that melatonin attenuates the development of diabetes-induced cardiac dysfunction by preventing mitochondrial fission through SIRT1-PGC1alpha pathway, which negatively regulates the expression of Drp1 directly. PMID: 29575122
    3. Nicotinamide riboside (NR) can protect against ethanol induced liver injuries via replenishing NAD(+), reducing oxidative stress, and activating SirT1-PGC-1a-mitochondrial biosynthesis. Our data indicate that SirT1 plays an important role in the protection of NR against lipid accumulation and mitochondrial dysfunctions induced by ethanol PMID: 29679894
    4. Findings demonstrated that one bout of both uphill and downhill exercise trainings as well as 8 weeks of training could increase the expression of PGC-1alpha and FNDC5 genes in the muscle tissues and the UCP1 gene in the subcutaneous adipose tissue. PMID: 30218749
    5. Studied the involvement of peroxisome proliferative activated receptor gamma coactivator 1 alpha (PGC-1a) in beta-cell dysfunction and impairment of its ability to secrete insulin. PMID: 28259539
    6. At least in the subcutaneous fat of humans and mice, the levels of PGC-1a decrease during obesity, while its physical association with A20 increases. PMID: 29678181
    7. During catecholamine-stimulated lipolysis, Perilipin 5 is phosphorylated by protein kinase A and forms transcriptional complexes with PGC-1alpha and SIRT1 in the nucleus. Perilipin 5 promotes PGC-1alpha co-activator function by disinhibiting SIRT1 deacetylase activity. PMID: 27554864
    8. the coordinated expression of FNDC5 and PGC-1alpha may contribute to the increased levels of plasma irisin after exercise. PMID: 29415899
    9. Endogenous PGC1alpha expression exhibited protective effects against oxidative stress, glomerulosclerosis and tubulointerstitial fibrosis in experimental diabetic kidney disease. PMID: 29344670
    10. Resistin inhibited the activation of CREB, resulting in suppression of PGC-1alpha. Importantly, overexpressing PGC-1alpha can rescue the inhibitory effects of resistin on fatty acid beta oxidation. PMID: 29730652
    11. A cap-binding protein 80 (CBP80)-binding motif (CBM) in the C terminus of PGC-1alpha is critical for the association of PGC-1alpha with CBP80 at the 5' cap of target transcripts. PMID: 29654059
    12. findings support the hypothesis that maternal diabetes-induced ER stress increases CHOP expression which represses PGC-1alpha through suppressing the C/EBPbeta transcriptional activity, subsequently induces mitochondrial dysfunction and ultimately results in NTDs PMID: 28482072
    13. PGC-1alpha does not seem to regulate the activity of hepatic unfolded protein response in response to exercise training, but to influence the capacity of the liver to induce UPR in a pathway specific manner. PMID: 28801170
    14. AMPK-PGC-1a control of mitochondrial reactive oxygen species regulates Warburg metabolism. PMID: 28978464
    15. At 11 weeks, the MCK-PGC-1alpha animals had 50% greater glucose tolerance integrated area under the curve compared with WT. PMID: 28639297
    16. In the absence of serum, hypoxia and high glucose conditions, PGC-1alpha can regulate the expression of Bcl-2 and promote the survival of MSCs via PGC-1alpha/ERRalpha interaction. PMID: 28711948
    17. PGC-1alpha is involved in resveratrol-induced microglia M2 polarization. PGC-1alpha regulates microglia polarization through NF-kappaB, STAT6 and STAT3 pathways PMID: 28268115
    18. Study provides evidence that PGC-1a is a mediator of ischemic preconditioning that is downregulated in the steatotic liver, blunting the induction of protective antioxidant enzymes. PMID: 28269997
    19. that oxidatively-mediated reductions in parkin solubility and function in a mouse model of age-related sporadic PD coincides with increased PARIS levels and reduced PGC-1alpha signaling PMID: 27185595
    20. in the skeletal muscle, PGC-1alpha activates ALT2 gene expression, and alanine production may play roles in adaptation to fasting PMID: 29315328
    21. PPAR-beta increases PGC-1alpha content via a reduction in protein degradation. PMID: 28467933
    22. Muscle-specific PGC-1alpha transgenic mice have lower satellite cell number. SCs from these mice have a higher propensity for activation and proliferation. PMID: 27908291
    23. Full length-PGC-1alpha-deficient mice can be regarded not only as morphological but behavioral models of mitochondrial encephalopathies PMID: 27424777
    24. The Genomic Context and Corecruitment of SP1 Affect ERRalpha Coactivation by PGC-1alpha in Muscle Cells PMID: 27182621
    25. These findings indicate that IGF-II reduces PGC-1alpha expression in skeletal muscle cells through a mechanism involving PI3K-Akt-FoxO1 but not p38 MAPK or Erk1/2 MAPK pathways. PMID: 28374141
    26. Findings demonstrate that PGC-1alpha protects against podocyte depletion and phenotypic changes possibly by maintaining normal mitochondrial function. PMID: 26943584
    27. The involvement of mTOR-PGC-1alpha pathway in the connection between FTO and muscle differentiation is displayed. PMID: 28333151
    28. findings indicate that exercise intensity affected autophagy markers differently in skeletal muscle and suggest that PGC-1alpha regulates both acute and exercise training-induced autophagy in skeletal muscle potentially in a PGC-1alpha isoform specific manner PMID: 29049322
    29. EET-mediated increase in HO-1 levels require PGC-1alpha expression PMID: 27418542
    30. This change in the cellular location of p53 alleviates the abrogation of PGC-1a repression caused by nuclear p53, which may further increases PGC-1a expression PMID: 27497229
    31. Peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) exerts beneficial effects on muscle inflammation that might contribute to the therapeutic effects of elevated muscle PGC-1alpha in different models of muscle wasting. PMID: 27833743
    32. Adult conditional PGC-1alpha knock-out mice show a significant loss of dopaminergic neurons that is accompanied by a reduction of dopamine in the striatum. Study identifies also two brain-enriched isoforms of PGC-1alpha: PGC-1alpha1L (160 kDa) and PGC-1alpha1S (100 kDa). PMID: 27622213
    33. The study propose that gluconeogenesis driven by NTPGC- 1a, along with PGC-1a, contributes to the elevated blood glucose level in response to fasting. PMID: 27798359
    34. Metagenomic analysis revealed direct correlation between PPARGC1A, SNAI1, and metastatic lung disease. PMID: 28803067
    35. Destabilization of PGC1a is attributable to decreased p38 MAPK activation via diminished CaMKII signaling. Thus, we elucidate a pathway downstream of Ca(2+)-mediated CaMKII activation that is dysfunctional in C3KO(Capn3 knock-out mice ) mice, leading to reduced transcription of genes involved in muscle adaptation PMID: 27005420
    36. lncBATE10 can decoy Celf1 from Pgc1alpha, thereby protecting Pgc1alpha mRNA from repression by Celf1 PMID: 28763438
    37. this study shows that PGC-1alpha overexpression improves metabolism in virus-specific CD8+ T cells generated during acute infection PMID: 27496729
    38. this study reports that tumor-infiltrating T cells show a progressive loss of PGC1alpha, and that overexpression of PGC1alpha results in superior intratumoral T cell functions PMID: 27496732
    39. This is the first study to dissect the mechanism by which the antiadipogenic and anti-inflammatory lipid, Epoxyeicosatrienoic acid, induces the PGC-1alpha signaling cascade and reprograms the adipocyte phenotype by regulating mitochondrial function and HO-1 expression. PMID: 27224420
    40. The accelerated conversion of T4 to T3 within myocytes mediates part of the PGC-1a induction by treadmill exercise and its downstream effects on mitochondrial function PMID: 27302464
    41. Study demonstrates a novel role for peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) in nucleus accumbens (NAc) in cocaine action. PGC-1alpha is enhanced in NAc dopamine D1-medium spiny neurons, specifically after cocaine exposure. These data are consistent with increased active methylation and early growth response 3 binding at the PGC-1alpha promoter. PMID: 27939396
    42. These data reveal a new role for muscle PGC-1alpha in regulating the physiological adaptation to long-term LCHF diet administration. PMID: 28223292
    43. These results demonstrate a central role of skeletal muscle PGC-1alpha in the transcriptional regulation of systemic ketolytic capacity. PMID: 26849960
    44. PGC-1alpha expression in cardiomyocytes is regulated by interleukin-6 and is down-regulated in animals fed a high-fat diet. PMID: 27253588
    45. the data strengthen our previous findings that NT-PGC-1alpha regulates mitochondrial genes involved in thermogenesis and oxidative metabolism in brown and white adipocytes and further suggest that NT-PGC-1alpha regulates a broad spectrum of genes to meet cellular needs for adaptive thermogenesis. PMID: 27454177
    46. role of PGC-1alpha in renal mitochondrial biogenesis indicates that activation of PGC-1alpha in the context of renal disorders could be a valid therapeutic strategy to ameliorate renal mitochondrial dysfunction PMID: 27463191
    47. Results delineate a cross talk between a central pathway controlling metabolic regulation and cell adhesion, and identify PGC-1alpha as a molecular link between these two major cellular networks. PMID: 27984584
    48. Data suggest NT-Pgc-1alpha (alternative splicing isoform of nuclear protein Pgc-1alpha) is located in mitochondrial matrix in brown adipocytes, specifically enriched at D-loop region of mitochondrial DNA at promoter region of Lrpprc (leucine-rich PPR-motif containing protein); expression of NT-Pgc-1alpha (rather than Pgc-1alpha) in brown adipocytes appears to induce expression of electron transport chain complex proteins. PMID: 28473468
    49. Data suggest that PGC-1alpha and -1beta expression are not required for training-induced exercise performance, highlighting the contribution of PGC-1-independent mechanisms. PMID: 27780821
    50. Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 enrichment within the mitochondria and subsequent upregulation of FoxO3a-mediated mitochondria gene expression of PGC-1alpha and SOD2. PMID: 28286268

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  • 亚细胞定位：
    Nucleus. Nucleus, PML body.
  • 组织特异性：
    White quadriceps and red tibialis anterior (TA) muscles, liver, kidney and brown adipose tissue (at protein level). Skeletal muscle, brown adipose tissue, heart, kidney and brain.
  • 数据库链接：

    KEGG: mmu:19017

    STRING: 10090.ENSMUSP00000117040

    UniGene: Mm.259072