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  4. Recombinant Mouse Peptidyl-prolyl cis-trans isomerase FKBP1A (Fkbp1a)

Recombinant Mouse Peptidyl-prolyl cis-trans isomerase FKBP1A (Fkbp1a)

  • 中文名称：
    小鼠Fkbp1a重组蛋白
  • 货号：
    CSB-YP008691MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fkbp1a重组蛋白
  • 货号：
    CSB-EP008691MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fkbp1a重组蛋白
  • 货号：
    CSB-EP008691MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fkbp1a重组蛋白
  • 货号：
    CSB-BP008691MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fkbp1a重组蛋白
  • 货号：
    CSB-MP008691MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Fkbp1a; Fkbp1Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; EC 5.2.1.8; 12 kDa FK506-binding protein; 12 kDa FKBP; FKBP-12; Calstabin-1; FK506-binding protein 1A; FKBP-1A; Immunophilin FKBP12; Rotamase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-108
  • 氨基酸序列
    GVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFT LGKQEVIRGW EEGVAQMSVG QRAKLIISSD YAYGATGHPG IIPPHATLVF DVELLKLE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
  • 基因功能参考文献：
    1. Acute tacrolimus treatment transiently increases hepcidin in wild-type mice. FKBP12 preferentially targets the BMP receptor ALK2. ALK2 mutants defective in binding FKBP12 increase hepcidin expression in a ligand-independent manner, through BMP-SMAD signaling. PMID: 28864813
    2. FKBP51 is a central mediator of chronic pain. PMID: 26865567
    3. We demonstrate that FKBP12 and its ligands impact multiple aspects of muscle function. PMID: 25053409
    4. Fkbp1a-mediated regulation of Notch1 plays an important role in intercellular communication between endocardium and myocardium. PMID: 23571217
    5. FKBP12 is critically important in regulating trans-sarcolemmal ionic currents, predominately the voltage-gated Na+ current, I Na PMID: 22460357
    6. the impact of simulated ischemia and reperfusion on expression of the calcium handling proteins FKBP12 and FKBP12.6, and intracellular calcium dynamics was investigated. PMID: 22618235
    7. Data show that deletion of FKBP12 increased transforming growth factor-beta receptor activation and SMAD2/3 signaling. PMID: 21518963
    8. FKBP12 is a critical regulator of I(Na) and is important for cardiac arrhythmogenic physiology PMID: 21372286
    9. a trimeric-interaction among calcineurin, FKBP12, and RyR is important for the regulation of the RyR channel activity and may play an important role in the Ca(2+) signaling of muscle contraction and relaxation PMID: 12414688
    10. FKBP12 binding to RyR1 enhances the gain of skeletal muscle excitation-contraction coupling PMID: 12704193
    11. used systemic gene transfer in tumor-bearing mice to identify novel antiinvasive and antimetastatic functions for Fkbp8, and subsequently for Fkbp1a PMID: 14612567
    12. FKBP12 deficiency alters both orthograde and retrograde coupling between the L-type Ca2+ channel and RyR1 and the consequences of these changes depend on muscle type and activity PMID: 15289441
    13. manipulating the stoichiometry between calstabin2 and ryanodine receptor 2 can restore normal cardiac function in vivo PMID: 16481613
    14. analysis of FK506-rapamycin binding (FRB) protein mutant rescue with chemical ligands PMID: 17525916
    15. These data strongly suggests that FKBP-12 is altered in an experimental model of PD. PMID: 17877381
    16. FKBP12 deficiency results in less initial strength deficits and enhanced recovery from single (especially females) and repeated bouts of injury than wild type mice PMID: 18511525
    17. The results of this study indicate that FKBP12 plays a critical role in the regulation of mTOR-Raptor interactions, LTP, memory, and perseverative behaviors. PMID: 19081378
    18. tacrolimus alters intracellular calcium and eNOS by binding to FKBP PMID: 19177155

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  • 亚细胞定位：
    Cytoplasm, cytosol. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    FKBP-type PPIase family, FKBP1 subfamily
  • 数据库链接：

    KEGG: mmu:14225

    STRING: 10090.ENSMUSP00000037206

    UniGene: Mm.278458