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  4. Recombinant Mouse Paired box protein Pax-9 (Pax9)

Recombinant Mouse Paired box protein Pax-9 (Pax9)

  • 中文名称：
    小鼠Pax9重组蛋白
  • 货号：
    CSB-YP017495MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pax9重组蛋白
  • 货号：
    CSB-EP017495MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pax9重组蛋白
  • 货号：
    CSB-EP017495MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pax9重组蛋白
  • 货号：
    CSB-BP017495MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pax9重组蛋白
  • 货号：
    CSB-MP017495MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pax9
  • Uniprot No.：
  • 别名：
    Pax9; Pax-9Paired box protein Pax-9
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-342
  • 氨基酸序列
    MEPAFGEVNQ LGGVFVNGRP LPNAIRLRIV ELAQLGIRPC DISRQLRVSH GCVSKILARY NETGSILPGA IGGSKPRVTT PTVVKHIRTY KQRDPGIFAW EIRDRLLADG VCDKYNVPSV SSISRILRNK IGNLAQQGHY DSYKQHQPAP QPALPYNHIY SYPSPITAAA AKVPTPPGVP AIPGSVALPR TWPSSHSVTD ILGIRSITDQ GVSDSSPYHS PKVEEWSSLG RNNFPAAAPH AVNGLEKGAL EQEAKYGQAP NGLPAVSSFV SASSMAPYPT PAQVSPYMTY SAAPSGYVAG HGWQHAGSTP LSPHNCDIPA SLAFKGMQAA REGSHSVTAS AL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.
  • 基因功能参考文献：
    1. Pax9-dependent Wnt signaling has a role in palatogenesis and cleft palates PMID: 28893947
    2. The formation of endoderm-derived taste sensory organs requires a Pax9-dependent expansion of embryonic taste bud progenitor cells. A primary function for Pax9 in the expansion of taste progenitor fields in taste papillae. PMID: 25299669
    3. Transfection of Pax9 and Bmp4 into mouse induced pluripotent stem cells facilitates their differentiation into odontoblast-like cells for cell- and tissue-based therapy. PMID: 26136503
    4. Disruption of Slc25a21 is associated with orofacial defects and otitis media due to diminished expression of a neighboring gene, pax9. PMID: 24642684
    5. Our data indicate that Pax9 regulates a molecular network involving the Bmp4, Fgf10, Shh and Osr2 pathways to control palatal shelf patterning and morphogenesis. PMID: 24173808
    6. Thymopoiesis requires Pax9 function in thymic epithelial cells. In Pax9 null mice, the thymic anlage develops as an ectopic polyp-like structure in the larynx, fails to perform the normal caudo-ventral movement to the upper mediastinum, and remains small. PMID: 11932925
    7. PAX9 has a role in tooth development in humans PMID: 14607846
    8. Pax9 regulates appendage formation in the mammalian tongue and is an important factor for the region-specific differentiation of the surface ectoderm. PMID: 15454262
    9. Changes of Pax9 expression levels have a direct consequence for mammalian dental patterning and a minimal Pax9 gene dosage is required for normal morphogenesis and differentiation throughout tooth development. PMID: 16236760
    10. Loss binding of pax9 to promoter correlated well with the severity of the tooth agenesis pattern in vivo. PMID: 19429910

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    In the embryo, expressed in pharyngeal pouches and derivatives, developing vertebral column, tail, head and limbs.
  • 数据库链接：

    KEGG: mmu:18511

    STRING: 10090.ENSMUSP00000001538

    UniGene: Mm.5035