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  4. Recombinant Mouse PDZ domain-containing protein GIPC1 (Gipc1)

Recombinant Mouse PDZ domain-containing protein GIPC1 (Gipc1)

  • 中文名称：
    小鼠Gipc1重组蛋白
  • 货号：
    CSB-YP897448MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gipc1重组蛋白
  • 货号：
    CSB-EP897448MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gipc1重组蛋白
  • 货号：
    CSB-EP897448MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gipc1重组蛋白
  • 货号：
    CSB-BP897448MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gipc1重组蛋白
  • 货号：
    CSB-MP897448MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gipc1
  • Uniprot No.：
  • 别名：
    Gipc1; Gipc; Rgs19ip1; Semcap1PDZ domain-containing protein GIPC1; GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; RGS19-interacting protein 1; SemaF cytoplasmic domain-associated protein 1; SEMCAP-1; Synectin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-333
  • 氨基酸序列
    MPLGLGRRKK APPLVENEEA EPSRSGLGVG EPGPLGGSAA GESQMGLPPP PAALRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPAAEVMFC TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE EALGLTITDN GAGYAFIKRI KEGSVIDHIQ LISVGDMIEA INGQSLLGCR HYEVARLLKE LPRGRTFTLK LTEPRKAFDM ISQRSAGGHP GSGPQLGTGR GTLRLRSRGP ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits endothelial cell migration (in vitro). May be involved in G protein-linked signaling.
  • 基因功能参考文献：
    1. GIPC1 forms a domain-swapped dimer in an autoinhibited conformation that hinders binding of both PlexinD1 and myosin VI. PlexinD1 binding to GIPC1 releases the autoinhibition, promoting its interaction with myosin VI. GIPCs and myosin VI interact through two distinct interfaces and form an open-ended alternating array. PMID: 28537552
    2. Down-regulation of endogenous GIPC1 is sufficient to inhibit the development of eye field cells from embryonic stem cells. PMID: 26013465
    3. Higher ratios of PSD-95/GluN2B and GAIP-interacting protein C-terminus (GIPC)/GluN2B were associated with poorer learning index scores across all ages. PMID: 23884936
    4. findings identify Gipc1 as a new interactor for Vangl2; show that a myosin VI-Gipc1 protein complex can regulate Vangl2 traffic in heterologous cells; results indicate a broad role for Gipc1 in the development of both stereociliary bundles and cell polarization PMID: 22991442
    5. TGFbetaR3 interaction with GIPC1 is critical for regulating invasion and growth factor responsiveness in epicardial cells, and dysregulation of epicardial cell proliferation and invasion contributes to failed coronary vessel development in Tgfbr3(-/-) mice PMID: 21871877
    6. GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion. PMID: 20634288
    7. Synectin is widely distributed in adult cells and tissues, and in the embryo apparent at day 4.5, peaks at day 12.5 and declines by day 18.5, and may be involved in mediation of outside-in signaling. PMID: 15527962
    8. Synectin selectively regulates arterial branching morphogenesis. PMID: 16740480
    9. Results define an important role for the Myo6-GIPC1 motor complex in presynaptic function and in BDNF-TrkB-mediated synaptic plasticity. PMID: 16819522
    10. a prototypical GIPC/synectin-binding receptor, revealed that deletion of its PDZ-binding motif drastically reduced GIPC/synectin and myosin VI recruitment to endocytic vesicles PMID: 16908842
    11. results confirm synectin involvement in FGF2-dependent signal transduction and provide insights into synectin-dependent gene expression in the endothelium PMID: 16940428
    12. Plays a role in arteriolar development. PMID: 17576142
    13. Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC PMID: 18775991
    14. synectin deficiency results in increased degradation of PDGF-BB protein in arterial endothelial cell and, consequently, reduced recruitment of mural cells to newly forming arteries PMID: 19235722
    15. Fibroblast growth factor 2-induced Rac1 activation depends on the suppression of RhoG by a previously uncharacterized ternary S4-synectin-RhoGDI1 protein complex and activation via PKCalpha. PMID: 19581409

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    GIPC family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: mmu:67903

    STRING: 10090.ENSMUSP00000019577

    UniGene: Mm.20945