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  4. Recombinant Mouse Oxysterols receptor LXR-beta (Nr1h2)

Recombinant Mouse Oxysterols receptor LXR-beta (Nr1h2)

  • 中文名称：
    小鼠Nr1h2重组蛋白
  • 货号：
    CSB-YP726663MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Nr1h2重组蛋白
  • 货号：
    CSB-EP726663MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Nr1h2重组蛋白
  • 货号：
    CSB-EP726663MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Nr1h2重组蛋白
  • 货号：
    CSB-BP726663MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Nr1h2重组蛋白
  • 货号：
    CSB-MP726663MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nr1h2
  • Uniprot No.：
  • 别名：
    Nr1h2; Lxrb; Rip15; Unr; Unr2; Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor subfamily 1 group H member 2; Retinoid X receptor-interacting protein No.15; Ubiquitously-expressed nuclear receptor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-446
  • 氨基酸序列
    MSSPTSSLDT PVPGNGSPQP STSATSPTIK EEGQETDPPP GSEGSSSAYI VVILEPEDEP ERKRKKGPAP KMLGHELCRV CGDKASGFHY NVLSCEGCKG FFRRSVVHGG AGRYACRGSG TCQMDAFMRR KCQLCRLRKC KEAGMREQCV LSEEQIRKKR IQKQQQQQPP PPSEPAASSS GRPAASPGTS EASSQGSGEG EGIQLTAAQE LMIQQLVAAQ LQCNKRSFSD QPKVTPWPLG ADPQSRDARQ QRFAHFTELA IISVQEIVDF AKQVPGFLQL GREDQIALLK ASTIEIMLLE TARRYNHETE CITFLKDFTY SKDDFHRAGL QVEFINPIFE FSRAMRRLGL DDAEYALLIA INIFSADRPN VQEPSRVEAL QQPYVEALLS YTRIKRPQDQ LRFPRMLMKL VSLRTLSSVH SEQVFALRLQ DKKLPPLLSE IWDVHE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis. Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex.
  • 基因功能参考文献：
    1. LXRbeta was dynamically expressed during dentate gyrus development.LXRbeta plays a central role in orchestrating the timely differentiation of neural progenitor cells within the dentate gyrus, thereby providing a likely explanation for its association with the genesis of autism-related behaviors in LXRbeta-deficient mice. PMID: 29507213
    2. Unr is required in vivo for the formation of Unr-containing nucleoplasmic reticulum because these structures are absent in Unr-null trophoblast giant cells. PMID: 28386023
    3. LXRbeta is involved in acute and inflammatory pain. PMID: 26846362
    4. PANDER strongly impacts hepatic lipid metabolism across metabolic states and may induce a selective hepatic insulin resistant phenotype via the LXR pathway. PMID: 27394190
    5. Data identify LXR as an important factor in early-pregnancy lipogenesis that is also necessary to protect against abnormalities in fetoplacental lipid homeostasis. PMID: 28420650
    6. Ativation of LXRbeta increases AQP2 protein levels in the renal collecting ducts via a posttranscriptional mechanism top regulate water electrolyte balance. PMID: 28052875
    7. Saponin-enriched sea cucumber extracts up-regulation hepatic LCR-beta signaling, preventing obesity in mice fed a high-fat diet. PMID: 26440226
    8. LXRB in Sertoli cells plays a role in the blood-testis barrier, germ cell epithelium integrity, paracrine action on Leydig cells modulating testosterone synthesis, paratubular smooth muscle function and metabolism, and lipid homeostasis. PMID: 26402841
    9. Liver X receptor beta controls thyroid hormone feedback in the brain and regulates browning of subcutaneous white adipose tissue. PMID: 26504234
    10. The oxysterol receptor LXRbeta protects against DSS- and TNBS-induced colitis in mice. PMID: 24803164
    11. results suggest that LXRbeta, by driving Radial Glial Cells to become oligodendrocytes in the dorsal cortex, is critical for white matter development and CNS myelination. PMID: 24934178
    12. Ligand-activated Liver X Receptor beta (LXRbeta) has an important function in cholesterol homeostasis and endogenous Abeta maintenance in neurons. PMID: 24394905
    13. ABCA12 regulates the cellular cholesterol metabolism via an LXRbeta-dependent posttranscriptional mechanism. PMID: 23931754
    14. A major effect of NCoR KOknockout in macrophages is to derepress LXR, which leads to the induction of lipogenic pathway genes. This causes increased biosynthesis of palmitoleic acid and omega3 fatty acids within macrophages, which exert robust local anti-inflammatory effects and are associated with the in vivo insulin sensitive phenotype. PMID: 24074869
    15. BMP macrophage accumulation reduced cholesterol efflux to both apolipoprotein A1 and high-density lipoprotein by 40% and correlated with a 40% decrease in mRNA contents of ABCA1, ABCG1, and liver-X receptor alpha and beta. PMID: 23788762
    16. Three new cell surface markers that could be useful to monitor LXR activation, were identified. PMID: 23185273
    17. Data indicate that myelin alters the macrophage Phenotype by activating the liver-X-receptor beta (LXRbeta) isoform. PMID: 22984598
    18. Results suggest that PIAS1 may serve as a lipogenic regulator by negatively modulating liver X receptors (LXRs) in a SUMOylation-independent manner. PMID: 22969086
    19. Liver X receptor beta protects dopaminergic neurons in a mouse model of Parkinson disease. PMID: 22826221
    20. Data show that the female LXRbeta(-/-) mice were anxious with impaired behavioral responses but normal locomotion and memory. PMID: 22529354
    21. The persistent high urine volume after arginine vasopressin administration was traced to a reduction in aquaporin-1 expression in the kidney of LXRbeta(-/-) mice. PMID: 22323586
    22. Data show that protein expression of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4 was downregulated upon LXR activation. PMID: 21398609
    23. Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity. PMID: 21173252
    24. LXRbeta is required to mediate many of the negative side effects of glucocorticoids. Mice lacking LXRbeta (but not LXRalpha) were resistant to dexamethasone-induced hyperglycemia, hyperinsulinemia, and hepatic steatosis. PMID: 21123945
    25. ABCA1 contributes to several beneficial effects of the LXR agonist GW3965 in APP/PS1 mice PMID: 20739291
    26. Findings suggest that LXRbeta in a complex interplay with estrogens and TGF-beta could play a crucial role in the malignant transformation of the gallbladder epithelium. PMID: 20679224
    27. LXRbeta appears to be a major regulator of glucose homeostasis and energy utilization and of fat storage in muscle and visceral white adipose tissue. PMID: 19690071
    28. Data suggest that reduction in the level of ApoER2 is the reason for the retarded migration of eurons in LXRbeta(-/-) mice. PMID: 20566868
    29. These results suggest that LXRbeta may inhibit neuroinflammation and maintain cholesterol homeostasis PMID: 20467332
    30. Thus, based on these findings we propose that LXR ligand such as T0901317, may be useful in the treatment of various inflammatory diseases. PMID: 20175894
    31. During liver regeneration LXR activity is abated in spite of increasing intracellular cholesterol levels. PMID: 20044803
    32. DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis PMID: 20080977
    33. In conclusion, LXRbeta seems to be the main LXR subtype regulating lipogenesis and cholesterol efflux in skeletal muscle. PMID: 19996385
    34. LXRbeta(-/-) mice have reduced insulin clearance during hyperinsulinemic euglycemic clamps and also reduced hepatic inflammation upon feeding an HFCD for 26weeks. PMID: 20079709
    35. selective synthetic agonists induce SUMOylation-dependent recruitment of either LRH-1 or LXR to hepatic APR promoters and prevent the clearance of the N-CoR corepressor complex upon cytokine stimulation PMID: 20159957
    36. the functional roles of LXR and ABCA1 in cholesterol trafficking processes in caput epididymidis PMID: 19395734
    37. A liver X receptor-beta alternative splicing variant LXRBSV acts as an RNA transcript not as a protein. PMID: 19878653
    38. Unr is required in vivo for efficient initiation of translation from the internal ribosome entry sites of both rhinovirus and poliovirus PMID: 12610110
    39. liver X receptor beta has a flexible ligand-binding pocket that can accommodate fundamentally different ligands PMID: 12819202
    40. LXRbeta is detected in the liver starting at 11.5 days postcoitum; later, LXRbeta is more ubiquitously expressed and enriched in tissues of neuronal and endocrine origin. PMID: 15052659
    41. LXR-beta receptors are important actors in epididymis function. PMID: 15525595
    42. Activation of liver X receptor results in reduction of tissue factor expression. PMID: 15752369
    43. crucial role for LXRbeta in retaining cholesterol homeostasis in Sertoli cells PMID: 15761042
    44. LXRbeta is required for expression of the cholesterol transporters, ABCA1 and ABCG1 PMID: 15831500
    45. by selectively sensing the cholesterol component of a lipid-rich diet, liver X receptors govern the balance between storage and oxidation of dietary fat. PMID: 16054068
    46. 24(S)-hydroxycholesterol induces apoE-mediated efflux of cholesterol in astrocytes via an LXR-controlled pathway PMID: 16524875
    47. LXRbeta modulates trabecular bone turnover. PMID: 16869726
    48. Laminar flow increases LXR function via a PPARgamma-CYP27 dependent mechanism, which reveals an atheroprotective role for laminar flow exerting on endothelium. PMID: 18096827
    49. The network of CD36 regulation by LXR, PXR, and PPARgamma establishes this free fatty acid transporter as a common target of orphan nuclear receptors in their mediation of lipid homeostasis. PMID: 18242221
    50. glucose is required for ChREBP functional activity and that LXRs are not necessary for the induction of glucose-regulated genes in liver. PMID: 18292813

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR1 subfamily
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    KEGG: mmu:22260

    STRING: 10090.ENSMUSP00000073188

    UniGene: Mm.968