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  4. Recombinant Mouse Osteopetrosis-associated transmembrane protein 1 (Ostm1), partial

Recombinant Mouse Osteopetrosis-associated transmembrane protein 1 (Ostm1), partial

  • 中文名称：
    小鼠Ostm1重组蛋白
  • 货号：
    CSB-YP805255MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ostm1重组蛋白
  • 货号：
    CSB-EP805255MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ostm1重组蛋白
  • 货号：
    CSB-EP805255MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ostm1重组蛋白
  • 货号：
    CSB-BP805255MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ostm1重组蛋白
  • 货号：
    CSB-MP805255MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ostm1
  • Uniprot No.：
  • 别名：
    Ostm1; Gl; Osteopetrosis-associated transmembrane protein 1; Chloride channel 7 beta subunit; Grey-lethal protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for osteoclast and melanocyte maturation and function.
  • 基因功能参考文献：
    1. KIF5B is essential for Ostm1 intracellular dispersion. PMID: 26598607
    2. Our in vivo structure-function analysis of ClC-7 reveals that both protein-protein interactions and ion transport must be considered in the pathogenesis of ClC-7-related diseases. PMID: 24820037
    3. Ostm1 has a primary and autonomous role in neuronal homeostasis PMID: 24719316
    4. Omi is a recessive mutation in the Ostm1 gene affecting teeth and coat color. PMID: 23160729
    5. Ostm1 is a bona fide target of miR-140, which is significantly decreased during adipogenic differentiation. PMID: 23389033
    6. Neuropathologic changes similar to neuronal ceroid lipofuscinosis are found in osteoporosis associated transmembrane protein 1 (Ostml)-deficient mice. PMID: 21107136
    7. mutation induces severe malignant autosomal recessive osteopetrosis; studies show that Gl protein function is absolutely required for osteoclast and melanocyte maturation and function PMID: 12627228
    8. both ClC-7 and Ostm1 proteins co-localize in late endosomes and lysosomes of various tissues, as well as in the ruffled border of bone-resorbing osteoclasts PMID: 16525474
    9. microphthalmia transcription factor regulates Clcn7 and Ostm1 expression in osteoclasts PMID: 17105730
    10. OSTM1 bone defect reveals an intercellular hematopoietic crosstalk PMID: 18790735

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  • 相关疾病：
    Defects in Ostm1 are the cause of the spontaneous gray-lethal (gl) mutant, which is responsible for a coat color defect and for the development of the most severe autosomal recessive form of osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood.
  • 亚细胞定位：
    Lysosome membrane; Single-pass type I membrane protein. Note=Requires CLCN7 to travel to lysosomes.
  • 蛋白家族：
    OSTM1 family
  • 组织特异性：
    Expressed primarily in osteoclasts and melanocytes as well as brain, kidney and spleen. Found at lower levels in the thymus, testis, heart and liver.
  • 数据库链接：

    KEGG: mmu:14628

    STRING: 10090.ENSMUSP00000035516

    UniGene: Mm.46636