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  4. Recombinant Mouse Odontogenic ameloblast-associated protein (Odam)

Recombinant Mouse Odontogenic ameloblast-associated protein (Odam)

  • 中文名称：
    小鼠Odam重组蛋白
  • 货号：
    CSB-YP016268MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Odam重组蛋白
  • 货号：
    CSB-EP016268MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Odam重组蛋白
  • 货号：
    CSB-EP016268MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Odam重组蛋白
  • 货号：
    CSB-BP016268MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Odam重组蛋白
  • 货号：
    CSB-MP016268MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Odam
  • Uniprot No.：
  • 别名：
    Odam; Apin; Odontogenic ameloblast-associated protein; Apin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    16-273
  • 氨基酸序列
    APLIS QRLLSASNSH ELLLNLNNGQ LLPLQFQGAF NSWIPPFPGF LQQQQAQVSG RPQFTLSTLE SFAGLFPNQI PLSRQVGLAQ GGQAGQPDLS QQQTPPQTQQ SASPMSYVVP VKVPQDQTQM FQYYPVYMLL PWEQPQTVTS SPQHTGQQLF EEQIPFYNQF GFAPPQAEPG VPGGQQHLAF DSFVGTAPET PGMPVEGSLL YPQKEPISFK HDNAGVFMPT TSPKPSTDNF FTSGIDPTIA PEQKVKTDSL REP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.
  • 基因功能参考文献：
    1. We propose that ODAM has diverse functions that vary with protein location in various cell lines. Nuclear ODAM appears to be associated with MMP-20 regulation and tumorigenesis. Additional functions may take place in cytoplasm and extracellular matrix. PMID: 22387195
    2. the BMP-2-BMPR-IB-ODAM-MAPK signaling cascade has important roles in ameloblast differentiation and enamel mineralization PMID: 22213140
    3. ODAM and AMTN are bona fide components of the basal lamina associated with maturation stage ameloblasts and they organize into different subdomains during the early maturation stage. PMID: 22231912
    4. Runx2 regulates the expression of ODAM and nuclear ODAM serves an important regulatory function in the mineralization of enamel through the regulation of MMP-20 apart from a different, currently unidentified, function of extracellular ODAM. PMID: 20665536
    5. The protein sequences deduced from the cloned cDNA for rat, mouse, pig, and human were aligned together with those obtained from four other mammal genomes. Apin is highly conserved in mammals. PMID: 17647262

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  • 亚细胞定位：
    Secreted. Cytoplasm. Nucleus.
  • 蛋白家族：
    ODAM family
  • 组织特异性：
    Highly expressed in tooth-associated epithelia. Predominantly expressed in mandible.
  • 数据库链接：

    KEGG: mmu:69592

    STRING: 10090.ENSMUSP00000108899

    UniGene: Mm.389652