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  4. Recombinant Mouse Nogo-B receptor (Nus1), partial

Recombinant Mouse Nogo-B receptor (Nus1), partial

  • 中文名称：
    小鼠Nus1重组蛋白
  • 货号：
    CSB-YP860384MO
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Nus1
  • Uniprot No.：
  • 别名：
    Nus1; D10Ertd438e; Ngbr; Dehydrodolichyl diphosphate synthase complex subunit Nus1; EC 2.5.1.87; Nogo-B receptor; NgBR; Nuclear undecaprenyl pyrophosphate synthase 1 homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic Domain
  • 来源：
    Yeast
  • 分子量：
    13.0kDa
  • 表达区域：
    24-120aa
  • 氨基酸序列
    SWLRVRFGTWNWIWRRCCRAASAAVLAPLGFTLRKPRAVGRNRRHHRHPHGGPGPGPGPAATHPRLRWRADVRSLQKLPVHMGLLVTEEVQEPSFSD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator.
  • 基因功能参考文献：
    1. Data demonstrate that NgBR is a unique receptor that promotes accumulation of prenylated Ras at the plasma membrane and promotes EGF pathways. PMID: 28068323
    2. NgBR is critical for protein glycosylation during vascular development. PMID: 26755743
    3. Loss of Nogo-B receptor in mice causes early embryonic lethality and defects in glycosylation. PMID: 25066056
    4. identify a previously uncharacterized Nogo-B receptor specific for the amino terminus of Nogo-B. PMID: 16835300
    5. Our results indicate that the NgBR ectodomain is intrinsically unstructured without tertiary structures while the cytoplasmic domain is partially folded with secondary structures but without a tight tertiary packing [nogo-b receptor] PMID: 17585875

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    UPP synthase family
  • 组织特异性：
    Highly expressed in heart, liver, kidney and pancreas.
  • 数据库链接：

    KEGG: mmu:52014

    STRING: 10090.ENSMUSP00000023830

    UniGene: Mm.199964