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  4. Recombinant Mouse Neuronal PAS domain-containing protein 1 (Npas1)

Recombinant Mouse Neuronal PAS domain-containing protein 1 (Npas1)

  • 中文名称：
    小鼠Npas1重组蛋白
  • 货号：
    CSB-YP015966MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Npas1重组蛋白
  • 货号：
    CSB-EP015966MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Npas1重组蛋白
  • 货号：
    CSB-EP015966MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Npas1重组蛋白
  • 货号：
    CSB-BP015966MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Npas1重组蛋白
  • 货号：
    CSB-MP015966MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Npas1
  • Uniprot No.：
  • 别名：
    Npas1; Neuronal PAS domain-containing protein 1; Neuronal PAS1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-594
  • 氨基酸序列
    MATPYPRSGG RGEVKCGGGR GAGVPWDFLP GLMVKAPPGP CLQAQRKEKS RNAARWRRGK ENLEFFELAK LLPLPGAISS QLDKASIVRL SVTYLRLRRF AALGAPPWGL RAVGPPAGLA PGRRGPVALV SEVFEQHLGG HILQSLDGFV FALNQEGKFL YISETVSIYL GLSQVELTGS SVFDYIHPGD HSEVLEQLGL RAASIGPPTP PSVSSSSSSS SSSLVDTPEI EASPTEASPA FRAQERSFFV RMKSTLTKRG LNVKASGYKV IHVTGRLRAR ALGLVALGHT LPPAPLAELP LHGHMIVFRL SLGLTILACE SRVSDHMDMG PSELVGRSCY QFVHGQDATR IRQSHLDLLD KGQVVTGYYR WLQRAGGFVW LQSVATVAGN GKSTGEHHVL WVSHVLSNAE GSQTPLDAFQ LPAIVSQEEP SRPGPEPTEE EPPVDGKQAV PADQDKDKDP QARGKRIKVE ASPKEARGSE DSGEEELSDP PAPPRPEFTS VIRAGALKHD PVLPWGLTTP GDPSPALLHA GFLPPVVRGL CTPGTIRYGP AELSLMYPHL HRLGAGPSLP EAFYPTLGLP YPGPTGTRVQ RKGD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level. Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH.
  • 基因功能参考文献：
    1. Study provides a clear, unbiased view of the full spectrum of genes regulated by NPAS1 and NPAS3 and shows that these transcription factors are master regulators of neuropsychiatric function. These findings expose the molecular pathophysiology of NPAS1/3 mutations and provide a striking example of the shared, combinatorial nature of molecular pathways that underlie diagnostically distinct neuropsychiatric conditions. PMID: 28499489
    2. Npas1-expressing neurons and parvalbumin-expressing neurons are two distinct functional classes of globus pallidus neurons. PMID: 26311767
    3. The result of this study provided the evidence that NPAS1 represses the generation of specific subtypes of cortical interneurons. PMID: 25467980
    4. a regulatory program controlled in inhibitory interneurons by the NPAS1 and NPAS3 transcription factors may be either substantively or tangentially relevant to psychosis PMID: 15347806
    5. Npas1 can regulate myofibroblast distribution, branching morphogenesis, and neuroendocrine cell differentiation in murine embryonic lung. PMID: 17110583
    6. These results suggest that NPAS1 plays a novel and important role in regulating TH level of dopaminergic neurons in the ventral midbrain during development. PMID: 17457889

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in brain in inhibitory interneurons. Also found in spinal cord.
  • 数据库链接：

    KEGG: mmu:18142

    STRING: 10090.ENSMUSP00000002053

    UniGene: Mm.145821