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  4. Recombinant Mouse Neuralized-like protein 1A (Neurl)

Recombinant Mouse Neuralized-like protein 1A (Neurl)

  • 中文名称：
    小鼠Neurl1重组蛋白
  • 货号：
    CSB-YP838762MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Neurl1重组蛋白
  • 货号：
    CSB-EP838762MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Neurl1重组蛋白
  • 货号：
    CSB-EP838762MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Neurl1重组蛋白
  • 货号：
    CSB-BP838762MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Neurl1重组蛋白
  • 货号：
    CSB-MP838762MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Neurl1
  • Uniprot No.：
  • 别名：
    Neurl1; Neurl; Neurl1aE3 ubiquitin-protein ligase NEURL1; EC 2.3.2.27; Neuralized-like protein 1A; m-neu1; m-neuralized 1; Neuralized1; RING-type E3 ubiquitin transferase NEURL1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-574
  • 氨基酸序列
    GNNFSSVSS LQRGNPSRAS RGHPQNLKDS IGGSFPVPSH RCHHKQKHCP PTLSGGGLPA TPLLFHPHTK GSQILMDLSH KAVKRQASFC NAITFSNRPV LIYEQVRLKI TKKQCCWSGA LRLGFTSKDP SRIHPDSLPK YACPDLVSQS GFWAKALPEE FANEGNIIAF WVDKKGRVFY RINESAAMLF FSGVRTVDPL WALVDVYGLT RGVQLLDSEL VLPDCLRPRS FTALRRPSLR CEADEARLSV SLCDLNVPGA DGDDGAPPAG CPIPQNSLNS QHSRALPAQL DGDLRFHALR AGAHVRILDE QTVARLEHGR DERALVFTSR PVRVAETIFI KVTRSGGGRA GALSFGVTTC DPGTLRPADL PFSPEALVDR KEFWAVCRVP GPLHSGDILG LVVNADGELH LSHNGAAAGM QLCVDASQPL WMLFSLHGAI TQVRILGSTI MTERGGPSLP CSPASTPTSP SALGIRLSDP LLSTCGSGPL GGSAGGTAPN SPVSLPESPV TPGLGQWSDE CTICYEHAVD TVIYTCGHMC LCYSCGLRLK KALHACCPIC RRPIKDIIKT YRSS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
  • 基因功能参考文献：
    1. Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1 protein stability through the E3 ligase Neuralized-like 1. PMID: 26276215
    2. These results suggest a model whereby Neuralized1-dependent ubiquitination facilitates hippocampal plasticity and hippocampal-dependent memory storage by modulating the activity of CPEB3 and CPEB3-dependent protein synthesis and synapse formation. PMID: 22153079
    3. molecular cloning, base sequence, amino acid sequence, and embryo tissue localization PMID: 11997106
  • 亚细胞定位：
    Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, dendrite. Cell junction, synapse, postsynaptic density.
  • 组织特异性：
    Expressed in CA1 pyramidal neurons (at protein level). Expressed throughout the adult forebrain, including the cerebral cortex, amygdala, striatum, and CA1 area of the hippocampus. Expressed in sensory neurons of the olfactory epithelium, the vomeronasal
  • 数据库链接：

    KEGG: mmu:18011

    STRING: 10090.ENSMUSP00000107439

    UniGene: Mm.313651