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  4. Recombinant Mouse Netrin receptor UNC5B (Unc5b), partial

Recombinant Mouse Netrin receptor UNC5B (Unc5b), partial

  • 中文名称：
    小鼠Unc5b重组蛋白
  • 货号：
    CSB-YP816978MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Unc5b重组蛋白
  • 货号：
    CSB-EP816978MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Unc5b重组蛋白
  • 货号：
    CSB-EP816978MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Unc5b重组蛋白
  • 货号：
    CSB-BP816978MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Unc5b重组蛋白
  • 货号：
    CSB-MP816978MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Unc5b
  • Uniprot No.：
  • 别名：
    Unc5b; Unc5h2Netrin receptor UNC5B; Protein unc-5 homolog 2; Protein unc-5 homolog B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
  • 基因功能参考文献：
    1. Negative regulation of Naa10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation. PMID: 27910960
    2. fibronectin leucine-rich transmembrane protein 2 (FLRT2), a repulsive ligand of the UNC5 receptor family for neurons, is unexpectedly expressed in endothelial cells specifically in the placental labyrinth. PMID: 28576770
    3. Blockade of Netrin-1/Unc5b by monoclonal antibodies prevents bone destruction and reduces the severity of K/BxN serum transfer-induced arthritis PMID: 27502509
    4. Data showed that albuminuria was significantly more pronounced in mice with proximal tubule specific deletion of UNC5B. PMID: 25896231
    5. UNC5B receptor deletion exacerbates DSS-induced colitis in mice by increasing epithelial cell apoptosis. PMID: 24720832
    6. unc5b expression is greater in adipose tissue of obese versus lean mice. PMID: 24584118
    7. UNC5B plays a critical role in cell survival and kidney injury through Akt-mediated inactivation of p53 in response to stress. PMID: 24115477
    8. These studies demonstrate an important role for UNC5B during myocardial ischemia-reperfusion injury. PMID: 23936025
    9. a significant role for UNC5B in the development of hepatic IRI and identified UNC5B as a potential drug target to prevent liver dysfunction in the future. PMID: 22848430
    10. Netrin-1 acting through the UNC5B receptor reduces renal ischemia-reperfusion injury and its associated renal inflammation. PMID: 20693423
    11. Unc5h2 was cloned; its mRNA is observed during early blood vessel formation, in the semicircular canal and in a dorsal to ventral gradient in the retina in developing mouse PMID: 12351186
    12. Disruption of the Unc5b gene leads to aberrant extension of endothelial tip cell filopodia, excessive vessel branching and abnormal navigation PMID: 15510105
    13. UNC5H2 physically interacts with the serine/threonine kinase death-associated protein kinase (DAP-kinase). PMID: 15729359
    14. The crystal structure of the mouse UNC5H2 death domain has been determined at 2.1 A resolution. PMID: 17139086
    15. UNC5B-mediated signaling is a specific and autonomous component of fetal-placental angiogenesis. PMID: 18223200
    16. PIKE-L acts as a downstream survival effector for netrin-1 through UNC5B in the nervous system PMID: 18469807
    17. Netrin-4 significantly reduced pathological angiogenesis in Matrigel and laser-induced choroidal neovascularization models. Netrin-4, neogenin, and Unc5B receptor expression was up-regulated in choroidal neovessel EC after laser injury PMID: 18719102
    18. Netrin-1 increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor. PMID: 19211685

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Membrane raft.
  • 蛋白家族：
    Unc-5 family
  • 组织特异性：
    Highly expressed in brain. Expressed in lung during late development. Expressed during early blood vessel formation, in the semicircular canal and in a dorsal to ventral gradient in the retina.
  • 数据库链接：

    KEGG: mmu:107449

    STRING: 10090.ENSMUSP00000077080

    UniGene: Mm.290433