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  4. Recombinant Mouse Natural resistance-associated macrophage protein 1 (Slc11a1), partial

Recombinant Mouse Natural resistance-associated macrophage protein 1 (Slc11a1), partial

  • 中文名称：
    小鼠Slc11a1重组蛋白
  • 货号：
    CSB-YP021380MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc11a1重组蛋白
  • 货号：
    CSB-EP021380MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc11a1重组蛋白
  • 货号：
    CSB-EP021380MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc11a1重组蛋白
  • 货号：
    CSB-BP021380MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc11a1重组蛋白
  • 货号：
    CSB-MP021380MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc11a1
  • Uniprot No.：
  • 别名：
    Slc11a1; Bcg; Ity; Lsh; Nramp1; Natural resistance-associated macrophage protein 1; NRAMP 1; Solute carrier family 11 member 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
  • 基因功能参考文献：
    1. Our data demonstrated the fine-tuning roles of Slc11a1 alleles modulating macrophage activation, and consequent pristane-induced arthritis susceptibility. PMID: 28669029
    2. Here, the s show that genetic inactivation of a single DDM1/Lsh family nucleosome remodeler biases methylation toward inter-nucleosomal linker DNA in Arabidopsis thaliana and mouse. The results indicate that in the absence of remodeling, nucleosomes are strong barriers to DNA methyltransferases. PMID: 29140247
    3. discrete, anatomically localized host resistance is conferred by Nramp1 expression; restriction of systemic bacterial growth in the spleen is enhanced by Nramp1 expression PMID: 25350459
    4. Data shows that Lsh plays an essential Dnmt3b-independent role to ensure that the host genome integrity is protected from potentially deleterious LTR retroelements. PMID: 24367978
    5. Gene expression profiles of the two arthritis quantitative trait loci (on chromosomes 5 and 8) correlate with Slc11a1 alleles, resulting in enhanced AIRmax(SS) mice susceptibility to Pristane-induced arthritis. PMID: 24505471
    6. In the absence of LSH, the histone variant H2AX is not efficiently phosphorylated in response to DNA damage. PMID: 22946062
    7. These observations indicate a bifunctional protective role of secretory Prx; first it reduces redox activation of macrophages, and secondly it allows iron access to Leishmania by down regulating NRAMP1 expression. PMID: 23326430
    8. Preferential expression of SLC11A1 transcripts in gammadelta T cells is detected in bovine, human, and mouse gammadelta T cells. PMID: 23509347
    9. Stimulation of Lcn2 expression is a novel mechanism by which Nramp1 confers resistance against infection with Salmonella typhimurium. PMID: 22706314
    10. High inflammatory AIRmax mice homozygous for Slc11a1 R and S alleles were produced. The Slc11a1 gene modulated the early inflammatory events of ear tissue regeneration. PMID: 20665098
    11. The Yersinia pseudotuberculosis mntH mutant was defective in survival and growth in macrophages expressing functional Nramp1, but in macrophages deficient in Nramp the bacteria were able to survive and replicate. PMID: 21183572
    12. conclude that rs3731685 (INT4) in the SLC11A1 gene may be associated with T1D susceptibility in the European ancestry population studied PMID: 21524304
    13. Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences. PMID: 21427231
    14. Findings indicate that DeltaNp63alpha is an oncogene that cooperates with Ras to promote tumor-initiating stem-like proliferation and suggest that Lsh-mediated chromatin-remodeling events are critical to this process. PMID: 21295273
    15. Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling. PMID: 20394798
    16. Results indicate that Lsh is involved in the control of stem cell genes and suggest that Lsh is an important epigenetic modulator during early stem cell differentiation. PMID: 19650037
    17. Affects macrophage-mediated anti-cryptococcal defense PMID: 11599791
    18. Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake PMID: 11903051
    19. involvement of Nramp1 in controlling S. enteritidis clearance during the late phase of infection PMID: 12058254
    20. repression of promoter by c-Myc and activation by Miz-1 PMID: 12110671
    21. Data show that M. avium was unable to prevent phagosome maturation and fusion with lysosomes but that in Nramp1-negative macrophages this capacity was restored. PMID: 12174088
    22. results suggest that generation of oxidants by Nramp1 iron transport activates MAP kinase signaling cascades that result in stabilization of Nramp1 mRNA PMID: 12202156
    23. Epression of the mouse macrophage NRAMP1-mediated resistance to Mycobacterium avium is not affected by the respiratory burst PMID: 12368449
    24. Disruption of the Slc11a1 gene in Kupffer cells attenuates early-phase, warm ischemia-reperfusion injury in the mouse liver. PMID: 12429710
    25. Host resistance factor Nramp1 up-regulates the expression of Salmonella pathogenicity island-2 virulence genes. PMID: 12441401
    26. the role of Slc11a1 in iron metabolism and iron recycling in macrophages PMID: 12527228
    27. expression of the Nramp1 gene appears to be of limited importance for the natural resistance of mice to Brucella PMID: 12540538
    28. Nramp1 promoter is transactivated by Miz-1 PMID: 12840021
    29. Nramp1 alleles clearly affect the efficacy of heat-killed Mycobacterium vaccae in diminishing the allergic and asthmatic response in a mouse model. PMID: 12847242
    30. Nramp1-expressing RAW264.7 macrophages present with increased nitric oxide formation and inducible nitric oxide synthase (iNOS) activity following cytokine stimulation, which can be related to enhanced and prolonged iNOS mRNA expression. PMID: 12902503
    31. Salmonella typhimurium can persist for as long as 1 yr in the mesenteric lymph nodes (MLNs) of 129sv Nramp1(+)(/)(+) (Slc11a1(+)(/)(+)) mice despite the presence of high levels of anti-S. typhimurium antibody. PMID: 14734525
    32. mice functionally deleted of the Nramp1 gene were not more susceptible to infection with virulent R. equi (ATCC 33701) than wild-type mice PMID: 15045472
    33. To investigate the molecular pathogenesis of infectious disease susceptibility, we compared the behaviour of heterologously and endogenously expressed wild-type and mutant Slc11a1. PMID: 15202932
    34. Oxidative stress mediated protection by Nramp1 function may arise from direct removal of redox-active bivalent cations from a cytosolic pool. PMID: 15506949
    35. The Slc11a1 encodes a late endosomal/lysosomal protein/divalent cation transporter, which regulates iron homeostasis in macrophages. PMID: 15601666
    36. The epigenetic regulator, Lsh, is directly involved in the control of de novo methylation of DNA. PMID: 16395332
    37. Nramp1 controls macrophage secretory leukocyte protease inhibitor mRNA and protein expression, and can also have an important effect on the kinetics of wound healing. PMID: 16470178
    38. results demonstrate a role for Slc11a1 (Nramp1) in modifying susceptibility to type 1 diabetes and illustrate that RNAi can be used to study causal genes in a mammalian model organism PMID: 16550170
    39. The pattern of susceptibility of congenic mouse strains infected with Paracoccidioides brasiliensis resembles the pattern of the Nramp1 gene. PMID: 16706788
    40. Data demonstrate a role for NRAMP1 in modulating p38 MAPK and PKCzeta activity, which leads to reduced cytokine induction by TLR7 ligands. PMID: 16706797
    41. YGSI is a tyrosine-based sorting signal responsible for lysosomal targeting of Nramp1 PMID: 16905747
    42. findings demonstrate that acute inflammatory reactions quantitative trait loci (AIR QTL) can act as modifiers of the Slc11a1(SS) susceptibility gene for Salmonella typhimurium infections PMID: 17035062
    43. These results indicate that Slc11a1 is a strong candidate for the QTL modulating acute inflammation and for pristane-induced arthritis. PMID: 17122779
    44. results indicate that MyD88-deficient mice could be a useful model to study C. jejuni colonization and reveal a potential role for Nramp1 in the control of this bacterial pathogen PMID: 17194808
    45. Homozygous maximum (AIRmax) and minimum (AIRmin) acute inflammation sublines for the Slc11a1 gene were produced to examine the interaction of this gene with the acute inflammatory loci. PMID: 17486412
    46. wild-type Slc11a1 expressed in dendritic cells may play a role both in determining resistance to infectious disease and in susceptibility to autoimmune disease such as type 1 diabetes. PMID: 17620357
    47. susceptibility or resistance to infection caused by M. avium largely depended upon the Slc11a1 genotype and that other genetic traits had a relatively weak influence. PMID: 17664269
    48. Functional expression of NRAMP-1 results in lower macrophage PTP activity and increased protein phosphorylation. PMID: 17942403
    49. interplay between repression and activation state of the Nramp1 promoter mediated by IRF-8 provides the molecular basis by which macrophages resist intraphagosomal pathogens at early stage after infection PMID: 18045875
    50. study found that macrophages lacking functional Nramp1 exhibited a significantly higher iron uptake via transferrin receptor 1 and, as a consequence of this, an increased iron release which is mediated via the iron export protein ferroportin-1 PMID: 18086376

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    NRAMP family
  • 组织特异性：
    Macrophages; spleen and liver.
  • 数据库链接：

    KEGG: mmu:18173

    STRING: 10090.ENSMUSP00000027368

    UniGene: Mm.2913