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  4. Recombinant Mouse Nasal embryonic luteinizing hormone-releasing hormone factor (Nelf)

Recombinant Mouse Nasal embryonic luteinizing hormone-releasing hormone factor (Nelf)

  • 中文名称：
    小鼠Nsmf重组蛋白
  • 货号：
    CSB-YP859576MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Nsmf重组蛋白
  • 货号：
    CSB-EP859576MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Nsmf重组蛋白
  • 货号：
    CSB-EP859576MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Nsmf重组蛋白
  • 货号：
    CSB-BP859576MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Nsmf重组蛋白
  • 货号：
    CSB-MP859576MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nsmf
  • Uniprot No.：
  • 别名：
    Nsmf; Jac; Nelf; NMDA receptor synaptonuclear signaling and neuronal migration factor; Juxtasynaptic attractor of caldendrin on dendritic boutons protein; Jacob protein; Nasal embryonic luteinizing hormone-releasing hormone factor; Nasal embryonic LHRH factor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-532
  • 氨基酸序列
    GAAASRRRA LRSEAMSSVA AKVRAARAFG EYLSQSHPEN RNGADHLLAD AYSGHDGSPE MQPAPQNKRR LSLVSNGRYE GSISDEAVSG KPAIEGPQPH VYTISREPAL LPGSEAEAIE LAVVKGRRQR ERHPHHHSQP LRASPGSSRE DISRPCQSWA GSRQGSKECP GCAQLVPGPS SRAFGLEQPP LPEAPGRHKK LERMYSVDGV SDDVPIRTWF PKENLFSFQT ATTTMQAISV FRGYAERKRR KRENDSASVI QRNFRKHLRM VGSRRVKAQT FAERRERSFS RSWSDPTPMK ADTSHDSRDS SDLQSSHCTL DEACEDLDWD TEKGLEAMAC NTEGFLPPKV MLISSKVPKA EYIPTIIRRD DPSIIPILYD HEHATFEDIL EEIEKKLNIY HKGAKIWKML IFCQGGPGHL YLLKNKVATF AKVEKEEDMI HFWKRLSRLM SKVNPEPNVI HIMGCYILGN PNGEKLFQNL RTLMTPYKVT FESPLELSAQ GKQMIETYFD FRLYRLWKSR QHSKLLDFDD VL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.
  • 基因功能参考文献：
    1. BDNF application can rescue the morphological deficits in hippocampal pyramidal neurons devoid of Jacob. Taken together, the data suggest that the absence of Jacob in early development interrupts a positive feedback loop between BDNF signaling PMID: 26977770
    2. NELF knockout is associated with impaired pubertal development and subfertility. PMID: 25731822
    3. Findings strongly indicate that NELF is part of the PPARalpha-mediated transcription regulatory network that maintains metabolic homeostasis in cardiomyocytes. PMID: 24656816
    4. Jacob operates as a mobile hub that docks NMDA receptor-derived signalosomes to nuclear target sites. PMID: 24317321
    5. The nuclear and non-nuclear NELF variant transcripts and proteins were identified, explaining variable NELF cellular localization. PMID: 24316376
    6. Study demonstrates that Jacob is a protein messenger that encodes the origin of synaptic versus extrasynaptic N-methyl-D-aspartate-receptors signals and delivers them to the nucleus. PMID: 23452857
    7. Calpain-mediated clipping of the myristoylated N terminus of Jacob is required for its nuclear translocation after N-methyl-d-aspartate receptor activation PMID: 19608740

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  • 亚细胞定位：
    Nucleus. Nucleus envelope. Nucleus membrane. Nucleus matrix. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cell junction, synapse. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density. Membrane.
  • 蛋白家族：
    NSMF family
  • 组织特异性：
    Preferentially expressed in immature migratory, in comparison to postmigrating, gonadotropin-releasing hormone (GnRH) neuronal cell lines (at protein level). Expressed in adult brain and liver. In the brain, expressed in the primary pituitary gland, corte
  • 数据库链接：

    KEGG: mmu:56876

    STRING: 10090.ENSMUSP00000097908

    UniGene: Mm.42956