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  4. Recombinant Mouse N-acylneuraminate cytidylyltransferase (Cmas)

Recombinant Mouse N-acylneuraminate cytidylyltransferase (Cmas)

  • 中文名称：
    Recombinant Mouse N-acylneuraminate cytidylyltransferase(Cmas),Yeast
  • 货号：
    CSB-YP857483MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse N-acylneuraminate cytidylyltransferase(Cmas),Yeast
  • 货号：
    CSB-EP857483MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse N-acylneuraminate cytidylyltransferase(Cmas),Yeast
  • 货号：
    CSB-EP857483MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse N-acylneuraminate cytidylyltransferase(Cmas),Yeast
  • 货号：
    CSB-BP857483MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse N-acylneuraminate cytidylyltransferase(Cmas),Yeast
  • 货号：
    CSB-MP857483MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cmas
  • Uniprot No.：
  • 别名：
    Cmas; N-acylneuraminate cytidylyltransferase; EC 2.7.7.43; CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-432
  • 氨基酸序列
    MDALEKGAVT SGPAPRGRPS RGRPPKLQRS RGAGRGLEKP PHLAALVLAR GGSKGIPLKN IKRLAGVPLI GWVLRAALDA GVFQSVWVST DHDEIENVAK QFGAQVHRRS SETSKDSSTS LDAIVEFLNY HNEVDIVGNI QATSPCLHPT DLQKVAEMIR EEGYDSVFSV VRRHQFRWSE IQKGVREVTE PLNLNPAKRP RRQDWDGELY ENGSFYFAKR HLIEMGYLQG GKMAYYEMRA EHSVDIDVDI DWPIAEQRVL RFGYFGKEKL KEIKLLVCNI DGCLTNGHIY VSGDQKEIIS YDVKDAIGIS LLKKSGIEVR LISERACSKQ TLSALKLDCK TEVSVSDKLA TVDEWRKEMG LCWKEVAYLG NEVSDEECLK RVGLSAVPAD ACSGAQKAVG YICKCSGGRG AIREFAEHIF LLIEKVNNSC QK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
  • 基因功能参考文献：
    1. Sialylation is dispensable for early murine embryonic development in vitro in CMAS-null embryonic stem cells. PMID: 28374933
    2. The s provide evidence that the C-terminal domain of CMP-Sialic Acid Synthetase (CSS) serves as a platform for the quaternary organization governing the kinetic properties of the physiologically active enzyme as demonstrated in kinetic studies.[CSS] PMID: 19666032
    3. Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity PMID: 11893746
    4. results describe the crystal structure of the N-terminal catalytically active domain of the murine 5-N-acetylneuraminic acid synthetase in complex with the reaction product PMID: 14636592
    5. the rainbow trout CMP-sialic acid synthetase utilises a nuclear localization signal different from that identified in the mouse enzyme PMID: 17580313

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    CMP-NeuNAc synthase family
  • 组织特异性：
    Highly expressed in brain and heart, and at intermediate level muscle and liver.
  • 数据库链接：

    KEGG: mmu:12764

    STRING: 10090.ENSMUSP00000032419

    UniGene: Mm.3820