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  4. Recombinant Mouse Mucosal addressin cell adhesion molecule 1 (Madcam1), partial

Recombinant Mouse Mucosal addressin cell adhesion molecule 1 (Madcam1), partial

  • 中文名称：
    小鼠Madcam1重组蛋白
  • 货号：
    CSB-EP717229MO
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Madcam1; Mucosal addressin cell adhesion molecule 1; MAdCAM-1; mMAdCAM-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Extracellular Domain
  • 来源：
    E.coli
  • 分子量：
    52.8kDa
  • 表达区域：
    22-364aa
  • 氨基酸序列
    QSFQVNPPESEVAVAMGTSLQITCSMSCDEGVARVHWRGLDTSLGSVQTLPGSSILSVRGMLSDTGTPVCVGSCGSRSFQHSVKILVYAFPDQLVVSPEFLVPGQDQVVSCTAHNIWPADPNSLSFALLLGEQRLEGAQALEPEQEEEIQEAEGTPLFRMTQRWRLPSLGTPAPPALHCQVTMQLPKLVLTHRKEIPVLQSQTSPKPPNTTSAEPYILTSSSTAEAVSTGLNITTLPSAPPYPKLSPRTLSSEGPCRPKIHQDLEAGWELLCEASCGPGVTVRWTLAPGDLATYHKREAGAQAWLSVLPPGPMVEGWFQCRQDPGGEVTNLYVPGQVTPNSSS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Both isoform 1 and isoform 2 can adhere to integrin alpha-4/beta-7. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
  • 基因功能参考文献：
    1. Nkx2-3 deficiency reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches. PMID: 25320278
    2. findings indicate that alpha4beta7*IgG can be used as a probe for functional MAdCAM-1 expressed on HEVs in GALT and could potentially serve as an anti-inflammatory drug inhibiting GALT-specific lymphocyte migration PMID: 21430257
    3. ectopic expression of MAdCAM-1 at the BBB does not increase alpha4beta7-integrin-mediated immune cell trafficking into the CNS during MOG(aa35-55)-induced experimental autoimmune encephalomyelitis PMID: 21341265
    4. Observed a significant decrease in expression of ICAM-1 and MAdCAM-1 mRNA/protein in lactobacillus plantarum treated colitis. PMID: 19960256
    5. results suggest that AT1R regulates the expression of MAdCAM-1 under colonic inflammatory conditions through regulation of the translocation of NF-kappaB into the nucleus PMID: 19940029
    6. Lymphocyte binding to MAdCAM-1 via alpha4beta7 integrin activates a signal transduction pathway involving tyrosine phosphorylation of paxillin and p105(Cas-L) PMID: 11947929
    7. Mucosal addressin cell adhesion molecule 1 plays an unexpected role in the development of mouse guard hair. PMID: 12230506
    8. spatial heterogeneity of MAdCAM-1 and VCAM-1 activation following TNF-alpha challenge may promote specific T lymphocyte recruitment in the inflamed colonic mucosa PMID: 12388196
    9. Increased expression of mucosal addressin cell adhesion molecule-1 in gastritis induced by Helicobacter pylori PMID: 12390304
    10. expression of MAdCAM-1 by fibroblasts and melanomas suggests MAdCAM-1 may play a role in regulating host responses in the periphery, leucocyte transmigration across nonendothelial boundaries, or the homotypic interactions of some malignant melanomas PMID: 12848854
    11. GST-3 is responsible for MECA-79 (MADCAM1)defined luminal ligands PMID: 15111310
    12. MAdCAM-1 plays important roles in T-lymphocyte adherence in all intestinal sites. PMID: 15371130
    13. In a chronic ileitis model, pathogenic CD4+ T cells use the MAdCAM-1/alpha4beta7 physiologic pathway in order to recirculate to the chronically inflamed small intestine. PMID: 15699171
    14. In wild-type mice administered blocking monoclonal antibody (mAb) to VCAM1-1 but nor to Madcam1 recruitment of mast cells to the inflamed lung was not reduced. PMID: 16670268
    15. These data indicate that TNF-alpha deficiency alters homoeostasis of the colonic chemokine/cytokine environment and humoral immune response, resulting in an exacerbation of acute DSS-induced colitis in TNF-alpha(-/-) mice. PMID: 17768420
    16. Combined effects of diabetes and pregnancy on pancreatic and decidual expression of VCAM-1, MAdCAM-1 and PNAd. PMID: 18031809
    17. Expression of MAdCAM-1 in isolated lymphoid follicles (ILFs) of the small intestine colocalizes with CD31 expression, indicating that MAdCAM-1 expression in ILFs is restricted to vascular structures. PMID: 18768861

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  • 相关疾病：
    Absence of Madcam1 in the spleen has been found in aly/aly mice, but normal expression is found in intestinal venules. This aberrant expression is a secondary defect and not the direct cause of aly alymphoplasia, an autosomal recessive mutation which induces total aplasia of lymph nodes and Peyer patches.
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Highly expressed on high endothelial venules (HEV) of organized intestinal lymphoid tissues like the Peyer patches and mesenteric lymph nodes, and in the lamina propria of the intestine. Some expression found in the spleen, and low levels of expression in
  • 数据库链接：

    STRING: 10090.ENSMUSP00000020554

    UniGene: Mm.391556