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  4. Recombinant Mouse Monocarboxylate transporter 4 (Slc16a3), partial

Recombinant Mouse Monocarboxylate transporter 4 (Slc16a3), partial

  • 中文名称：
    小鼠Slc16a3重组蛋白
  • 货号：
    CSB-YP021410MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc16a3重组蛋白
  • 货号：
    CSB-EP021410MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc16a3重组蛋白
  • 货号：
    CSB-EP021410MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc16a3重组蛋白
  • 货号：
    CSB-BP021410MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc16a3重组蛋白
  • 货号：
    CSB-MP021410MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc16a3
  • Uniprot No.：
  • 别名：
    Slc16a3; Mct4; Monocarboxylate transporter 4; MCT 4; Solute carrier family 16 member 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
  • 基因功能参考文献：
    1. MCT1 inhibition impairs proliferation of glycolytic breast cancer cells co-expressing MCT1 and MCT4 via disruption of pyruvate rather than lactate export. PMID: 26876179
    2. This study demonstrated that MCT4 was up regulation in the brain afeter cerebral ischemia. PMID: 26751713
    3. The soleus, liver and heart were the main tissues that showed improved the MCT1 mRNA expression, indicating its important role in controlling MLSS concentration in mice. PMID: 25470525
    4. MCT4-overexpressing mesenchymal stem cells preferentially induced cell death in cardiomyocytes. PMID: 25537659
    5. MCT4 depletion induced cell death characterized by elevated reactive oxygen species and metabolic crisis. In xenograft models, MCT4 had a significant impact on tumor metabolism and was required for rapid tumor growth. PMID: 25497091
    6. MCT4 is up-regulated in inflammation-activated macrophages and required for innate immune response. PMID: 25406319
    7. Nitric oxide represents an intercellular signal to control MCT4 expression in astrocytes; in doing so, it facilitates lactate transfer to other surrounding cell types in the central nervous system. PMID: 21901758
    8. MCT4 expression markedly increased the gradient between intracellular and extracellular pH from 0.14 to 0.43. PMID: 21484790
    9. MCT1 and MCT4 protein expression increased by 92 and 61%, respectively, after 12 days of functional overload (p < 0.05). PMID: 21826525
    10. In situ hybridization survey of MCT subtypes in placenta detected intense mRNA expression of MCT1, MCT4, & MCT9 (gestational day 11.5 through day 18.5); subcellular localization of MCT1 & MCT4 in cell membrane is opposite polarity found in human. PMID: 20022372
    11. Unique roles for slc16a3 in monocarboxylate transport and pH regulation during preimplantation development. PMID: 18385447

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Monocarboxylate porter (TC 2.A.1.13) family
  • 数据库链接：

    KEGG: mmu:80879

    STRING: 10090.ENSMUSP00000068854

    UniGene: Mm.28632